I R Whittle

..The pathophysiological basis of these iatrogenic neurological deficits, and techniques to minimize such problems are discussed...

..Awake brain tumour surgery allows intraoperative patient assessment and is done to optimise safe tumour removal. It is an established technique but little is known about patient perceptions of the procedure...

..Further in vitro and genetic studies will enable us to study these events and interactions in greater detail than is possible using other cell culture and in vivo systems...

..CONCLUSION: These data suggest that dexamethasone does not significantly affect tumor blood flow but may, by reducing peritumoral water content and local tissue pressure, subtly increase perfusion in the edematous brain...

..The intraparenchymal route was an effective method of GLA administration in the treatment of glioma. These studies provide further insights into the potential role of HUFAs as anti-glioma agents...

..Further in vivo stud ies using either behavioural or neuropathological paradigms in rodents with established cerebral glioma should be treated with similar doses of DXN to optimise clinical relevance...

..Quality of life studies basing conclusions on a complete case analysis should be wary of possible bias...

..We report the immediate effects of resective surgery on language functions in a heterogeneous group of patients with left-sided intracranial tumours...

..This study has highlighted significant unforeseen medical requirements and costs that can occur in MS patients who have thalamic DBS surgery...

..The clinical implications of these findings are discussed...

..This review will discuss the biological role of NO in the central nervous system and gliomas and its current and future possibilities in neuro-oncology...

..These findings once again demonstrate the differences between human malignant glioma and experimental implantation glioma models...

..The mechanisms that cause failure of tumour growth need clarification prior to considering that specific iNOS inhibitors might be candidates for adjuvant treatment of malignant glioma...

..This case adds to the reports of alleviation of movement disorders following either stereotactic thalamic mapping or placement of stimulating electrodes without macroscopic thalamic lesioning...

..Based on CT alone radiologists are good at identifying an intra-cerebral tumour, but not so good at distinguishing between different tumour types. The implications of the findings for patient management are discussed...

..4% (95% CI 1.7 to 3.3 %). The risk of postprocedural seizures associated with chronic deep brain stimulation is even lower with best estimates around 0.5% (95% CI .02 to 1.0%)...

..The rapid progression of this lesion during pregnancy suggests a hormonal mediated pathway for the tumour growth. Further analysis from the resected specimen confirmed that the tumour was oestrogen and progesterone receptors positive...

..Systematic review of shotgun proteomics and network analysis provides insight into meningioma pathophysiology despite the many barriers and difficulties that are inherent to this type of study...

..In this study we evaluate the efficacy of systemic BCNU and CCNU in experimental glioma models and how the experimental data has translated into clinical practice...

..The current status of proteomic technology, its application to gliomas and the utility of such translational studies is reviewed...

..Furthermore, the magnitude of these changes is similar for both intra- and extra-axial tumours...

..If the future use of Gliadel is limited to the eligibility criteria used in the phase III trial about 20% (95% confidence intervals 13-34%) of patients with newly diagnosed malignant glioma will receive this therapy...

..There is also a peritumoural region of up-regulated receptors that have many, predominantly inhibitory, functions. The relationship of these findings to peritumoural brain dysfunction is discussed...

..Informing patients of the uncertainties in both interventional strategies and the place of conservative management in LGG is essential in optimising patient outcomes and satisfaction...

..The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced...

..Although the current WHO (2000) classification is more prescriptive than its predecessors, interobserver variability is likely to remain because of the subjective nature of some of the criteria...

..Interval from surgery to RT had no impact on survival in this series...

..The relationships between the subdural hygromas, pseudomeningocele, location of the lesion within the cerebellum, cerebellar oedema, and the cause of her cognitive-affective syndrome are discussed...

..The limitations of this type of analysis, including how trial design can bias outcomes and militate against comparison of trials are discussed...

..Advanced age per se should not be a bar to interventional treatment in patients aged >60 years with suspected malignant glioma...

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..This preliminary study suggests that recording inspection time, in a neuro-oncological setting, may prove informative and practically useful in assessing non-motor processing speed in people with brain tumours...

..The aim of this study was to determine the incidence of mental incapacity, as assessed by neurosurgeons, in patients with intracranial tumours undergoing neurosurgery...

..The results of this study have implications for future studies using capillary permeability modifying agents as adjuncts to brain tumour chemotherapy...

..To the best of our knowledge, similar lesions at this site have not been reported in adults. The differential diagnosis with arachnoid cysts of the quadrigeminal CSF cistern is discussed...

..Our results showed that expressing elastance (dp/dv) instead of compliance (dv/dp) yielded fewer outliers and had a better correlation to ICP, and the ewma method had a better correlation to ICP than the Spiegelberg method...

..Further paradigm development is required for evaluation of language, and possibly other more complex executive functions...

..This case shows that quantitative MRI can not only measure steroid treatment response but also failure in patients with malignant gliomas...

..We therefore suggest that 11beta-hydroxysteroid dehydrogenase type 2 acts as to protect the developing nervous system from the deleterious consequences of glucocorticoid overexposure...

..It is also likely that the insignificant benefits of DBS on disability and handicap reflect persisting cerebeller dysmetria, and both the severity and diffuse nature of the disease process in this patient cohort...

..1988) in their original description of the lesion. The neuroradiological, neuropathological and clinical features of this case are compared with the two previous cases of multifocal DNET...

..Also, there was little evidence of acute inflammatory infiltration in regressing tumours. Our findings suggest that intraparenchymal infusion of HUFA may be effective in stimulating glioma regression...

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..ROS may have a role in AA induced cell death and anti-tumour activity of AA in glioma...