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Genomes and Genes | Robert J WhiteSummaryAffiliation: University of Glasgow Country: UK Publications
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Publications
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factorsThomas J Owen
School of Cancer Sciences, University of Birmingham, Birmingham, UK
Mol Cancer 9:241. 2010..We have recently demonstrated that EBV-encoded nuclear antigen-1 (EBNA1) induces cellular transcription factors, and given these findings, we investigated the role of EBNA1 in induction of EBER-associated transcription factors...- Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?R J White
Institute of Biomedical and Life Sciences, University of Glasgow, UK
Trends Biochem Sci 22:77-80. 1997..Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression... - RNA polymerases I and III, growth control and cancerRobert J White
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
Nat Rev Mol Cell Biol 6:69-78. 2005..Such events might have a significant impact on the growth potential of tumours... - RNA polymerase III transcription and cancerRobert J White
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, UK
Oncogene 23:3208-16. 2004..In addition to effects on protein synthesis and growth, there is a precedent for a pol III product having oncogenic activity... - Regulation of RNA polymerase III transcription during hypertrophic growthSarah J Goodfellow
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
EMBO J 25:1522-33. 2006..Increased production of tRNA and 5S rRNA will contribute to the enhanced translational capacity required to sustain hypertrophic growth... - The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIBZoe A Felton-Edkins
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, UK
EMBO J 22:2422-32. 2003..These data identify a novel target for ERK, and suggest that its ability to stimulate biosynthetic capacity and growth involves direct transcriptional activation of tRNA and 5S rRNA genes... - Regulation of RNA polymerase III transcription by Maf1 in mammalian cellsSarah J Goodfellow
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
J Mol Biol 378:481-91. 2008..These aspects of Maf1 function have been conserved between yeast and mammals and are therefore likely to be of fundamental importance in controlling pol III transcriptional activity... - p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIBDiane Crighton
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
EMBO J 22:2810-20. 2003..Together our results support the idea that p53 represses RNA pol III transcription through direct interactions with TBP, preventing promoter occupancy by TFIIIB... - Dr1 (NC2) is present at tRNA genes and represses their transcription in human cellsTheodoros Kantidakis
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
Nucleic Acids Res 38:1228-39. 2010..On the basis of these data, we conclude that the physiological functions of human Dr1 include regulation of pol III transcription... - TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcriptionNiall S Kenneth
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
Proc Natl Acad Sci U S A 104:14917-22. 2007..The selective acetylation of histone H3 distinguishes pol III activation by c-Myc from mechanisms observed in other systems... - Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformationLynne Marshall
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Cell 133:78-89. 2008..Overexpression of tRNA(iMet) is sufficient to stimulate cell proliferation and allow immortalized fibroblasts to form foci in culture and tumors in mice. The data indicate that elevated tRNA synthesis can promote cellular transformation... - TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivoJennifer A Fairley
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
EMBO J 22:5841-50. 2003..Repression can be reversed by raising the concentration of Brf1 or Bdp1. The data support a model in which hyperphosphorylation disrupts TFIIIB during mitosis, compromising its ability to support transcription... - A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIICFiona Innes
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK
Nucleic Acids Res 34:3399-407. 2006..However, little or no effect is seen on the expression of pol III transcripts. The data argue against the model that pol III transcription can be effectively modulated through the specific induction of TFIIIC110... - Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytesIsabelle Ernens
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Nucleic Acids Res 34:286-94. 2006..These effects are independent of cell cycle changes... - Direct activation of RNA polymerase III transcription by c-MycNatividad Gomez-Roman
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
Nature 421:290-4. 2003..These results suggest that activation of pol III may have a role in the ability of c-Myc to stimulate cell growth... - Recruitment of RNA polymerase III in vivoNiall S Kenneth
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
Nucleic Acids Res 36:3757-64. 2008..Promoter occupancy by pol II is unaffected, despite sharing five subunits with the pol III core. These observations provide evidence for the validity in vivo of the model for pol III recruitment that was built on biochemical data... - Regulation of RNA polymerase III transcription during mammalian cell growthSarah J Goodfellow
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Cell Cycle 6:2323-6. 2007..The complex network of strategies that couple pol III transcription with cell growth suggest that stringent control of this system is of fundamental importance... - Non-coding RNA production by RNA polymerase III is implicated in cancerLynne Marshall
Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
Nat Rev Cancer 8:911-4. 2008..New evidence suggests that Pol III output can substantially affect transformation... - Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirusNicole L Daly
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Oncogene 24:880-8. 2005..The resultant increase in biosynthetic capacity may contribute to deregulated cell growth... - RNA polymerases I and III, non-coding RNAs and cancerRobert J White
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
Trends Genet 24:622-9. 2008..The resultant increases in rRNA and tRNA expression might promote the generation of cancers... - Several regions of p53 are involved in repression of RNA polymerase III transcriptionTorsten Stein
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
Oncogene 21:5540-7. 2002..These observations reveal that repression of pol III transcription is a complex function involving multiple regions of p53 extending throughout much of the protein... - Human La is found at RNA polymerase III-transcribed genes in vivoJennifer A Fairley
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom
Proc Natl Acad Sci U S A 102:18350-5. 2005..However, gene occupancy depends on the phosphorylation status of La, with the less prevalent, unphosphorylated form being found selectively on pol III templates... - Coordinated control of the gene expression machineryRobert J White
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
Trends Genet 26:214-20. 2010..This occurs at both the transcriptional level, through the coordinate regulation of RNA polymerases I-III and downstream in the coordinate regulation of transcription with RNA processing and translation... - RNA polymerase III transcription is repressed in response to the tumour suppressor ARFJennifer P Morton
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK
Nucleic Acids Res 35:3046-52. 2007..However, in contrast to its effects on rRNA synthesis, ARF is unable to inhibit tRNA gene transcription when p53 is ablated. These results add to the growing list of cellular changes that can be triggered by ARF induction... - RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndromeTorsten Stein
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Oncogene 21:2961-70. 2002..Our data suggest that p53 status can have a profound effect upon pol III transcription and hence on the biosynthetic capacity of cells... - Regulation by c-Myc of ncRNA expressionNiall S Kenneth
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Curr Opin Genet Dev 19:38-43. 2009..This involves it regulating the transcriptional activity of three different RNA polymerases. These ncRNAs are likely to contribute substantially to the complex biology and pathology that is associated with c-Myc... - Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1Jennifer A Fairley
Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Mol Cell 45:541-52. 2012..Genomic instability is apparent in cells with Brf1 T270 mutated to alanine to resist Plk1-directed inactivation, suggesting that chromosome segregation is vulnerable to inappropriate pol III activity... - CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cellsImogen M Johnston
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom
Mol Cell Biol 22:3757-68. 2002..CK2 provides a rare example of an endogenous activity that operates on the PolIII system in both mammals and yeasts. Such evolutionary conservation suggests that this control may be of fundamental importance... - c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase ICarla Grandori
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Nat Cell Biol 7:311-8. 2005..We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis... - A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardiumEkaterini Angelis
The Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1760, USA
Circ Res 102:1222-9. 2008.... - The TATA-binding protein as a regulator of cellular transformationSandra A S Johnson
Department of Biochemistry and Molecular Biology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
Cell Cycle 2:442-4. 2003....