Research Topics
Genomes and Genes | Andreas WernerSummaryAffiliation: University of Newcastle Country: UK Publications
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Publications
Evolution of the Na-P(i) cotransport systemsA Werner
Department of Physiological Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
Am J Physiol Regul Integr Comp Physiol 280:R301-12. 2001..We hypothesize that the original NaPi-IIb-related gene was duplicated early in vertebrate development. The appearance of NaPi-IIa correlates with the development of the mammalian nephron...- Naturally occurring antisense RNA: function and mechanisms of actionAndreas Werner
RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, UK
Curr Opin Nephrol Hypertens 18:343-9. 2009..The transcription of an antisense RNA can influence the output of the specific gene locus on a posttranscriptional level but may also help to establish a local epigenetic imprint... - What do natural antisense transcripts regulate?Andreas Werner
RNA Research Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle, UK
RNA Biol 6:43-8. 2009..We also propose that endo-siRNAs are essential components of a regulatory network to control the mutagenic burden that unfolds on nucleic acid level without direct consequences on protein expression... - Natural antisense transcriptsAndreas Werner
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
RNA Biol 2:53-62. 2005..Consequently, there are at least two categories of natural antisense transcripts that show significant differences with regard to their biological function as well as the potential mechanisms involved... - Expression profiling of antisense transcripts on DNA arraysAndreas Werner
Epithelial Research Group, Institute for Cell and Molecular Biosciences
Physiol Genomics 28:294-300. 2007.... - Natural antisense transcripts: sound or silence?Andreas Werner
Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle, United Kingdom
Physiol Genomics 23:125-31. 2005..For the remaining, much larger group of bidirectionally transcribed genes, however, the physiological consequences of antisense transcription as well as the cellular mechanism(s) involved remain largely speculative... - Regulation of the NPT gene by a naturally occurring antisense transcriptAndreas Werner
Department of Physiological Sciences, University of Newcastle upon Tyne, UK
Cell Biochem Biophys 36:241-52. 2002..e., requiring supplementary factors like double-stranded RNA recognizing proteins or specific RNases). It is planned to test this hypothesis by a transgenic zebrafish approach and/or knockout mice... - What are natural antisense transcripts good for?Andreas Werner
RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Biochem Soc Trans 38:1144-9. 2010..The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs... - Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAsMark Carlile
RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
Physiol Genomics 34:95-100. 2008..Our findings may give important clues to understanding the physiological role of the widespread antisense transcription... - Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissuesMark Carlile
Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle, UK
Nucleic Acids Res 37:2274-82. 2009..Significant correlation between random imprinting and antisense transcription could indeed be established. Our findings suggest a novel, more general role for NATs in gene regulation... - Characterization of a type IIb sodium-phosphate cotransporter from zebrafish (Danio rerio) kidneyC Graham
School of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
Am J Physiol Renal Physiol 284:F727-36. 2003..The strong structural similarity but divergent function makes these zebrafish transporters ideal models for the molecular mapping of functionally important regions in the type II NaPi-cotransporter family... - Physiological and molecular mechanisms of inorganic phosphate handling in the toad Bufo bufoNadja Møbjerg
Institute of Molecular Biology, University of Copenhagen, August Krogh Building, Universitetsparken 13, 2100 Copenhagen, Denmark
Pflugers Arch 454:101-13. 2007..The presently cloned NaPi-IIb is a likely candidate involved in P(i) absorption across these epithelia. In addition, electrophysiological experiments suggest that the collecting duct system plays an important role in P(i) homeostasis... - Determination of thermodynamic parameters for HIV DIS type loop-loop kissing complexesAlbert Weixlbaumer
Max F. Perutz Laboratories, Department of Microbiology and Genetics, University of Vienna, Austria
Nucleic Acids Res 32:5126-33. 2004..The different dependence on ionic strength that is observed might reflect the contribution of specific divalent ion binding to the preformation of the hairpin loops poised for the tertiary kissing loop-loop contacts... - Hypertonic activation of phospholemman in solitary rat hepatocytes in primary cultureUdo Kirschner
Max Planck Institut fur molekulare Physiologie, Abteilung Epithelphysiologie, Otto Hahn Strasse 11, 44227 Dortmund, Germany
FEBS Lett 537:151-6. 2003..These results suggest a role of PLM in the RVI of rat hepatocytes...