Research Topics
Species | Nicholas Fs WatsonSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancerTimothy J Duncan
Academic Department of Clinical Oncology, Institute of Immunology, Infections and Immunity, University of Nottingham, City Hospital, Nottingham, UK
World J Surg Oncol 5:31. 2007..We propose that tumours lacking expression of MUC1 and MUC3 will be more likely to metastasise, due to previously observed loss of cell-cell adhesion, and this will therefore lead to more aggressive cancers with poorer prognosis...- High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomasZahra Madjd
Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
Breast Cancer Res 7:R780-7. 2005..The SC101 mAb is a unique Lewisy/b binding antibody that binds to native and extended Lewisy and Lewisb haptens, displaying no cross reactivity with H type 1, H type 2, Lewisx or normal blood group antigens... - Endovascular treatment of a Superior Mesenteric Artery Syndrome variant secondary to traumatic pseudoaneurysmIain Au-Yong
Department of Surgery, Royal Derby Hospital, Uttoxeter Road, Derby, DN22 3NE, UK
World J Emerg Surg 5:7. 2010..Exclusion of the pseudoaneurysm and relief of the duodenal obstruction were simultaneously achieved by placement of a covered stent... - Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patientsNicholas F S Watson
Section of Gastrointestinal Surgery, University of Nottingham, E Floor, West Block, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, United Kingdom
World J Gastroenterol 12:6299-304. 2006..To evaluate the prognostic significance of p27(kip1) in colorectal cancer patients... - A prospective audit of early pain and patient satisfaction following out-patient band ligation of haemorrhoidsN F S Watson
Department of Surgery, Queen s Medical Centre, Nottingham, UK
Ann R Coll Surg Engl 88:275-9. 2006..Information regarding early morbidity, pain and patient satisfaction following band ligation of haemorrhoids is limited. This is the first report to address these issues specifically... - Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patientsNicholas F S Watson
Academic Department of Clinical Oncology, University of Nottingham, City Hospital, Nottingham, United Kingdom
Int J Cancer 118:1445-52. 2006..In contrast, patients with high expression of MICA may be candidates for the antibody therapies, as they should be susceptible to NK killing by antibody dependent cellular cytotoxicity... - Malignant transformation of high-grade anal intraepithelial neoplasiaJ H Scholefield
Department of Surgery, Queens Medical Centre, Nottingham, UK
Br J Surg 92:1133-6. 2005..This makes management problematic as treatment options to eradicate the condition carry morbidity. The authors report their 10-year experience with conservative management of this condition, highlighting the lessons learnt... - Expression of the membrane complement regulatory protein CD59 (protectin) is associated with reduced survival in colorectal cancer patientsNicholas F S Watson
Academic Department of Clinical Oncology, City Hospital, University of Nottingham, Hucknall Road, Nottingham, NG5 1PB, UK
Cancer Immunol Immunother 55:973-80. 2006..This study has identified CD59 expression as a marker of poor prognosis in colorectal cancer patients... - Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patientsGustave J Ullenhag
Section of Gastrointestinal Surgery, University Hospital Nottingham, United Kingdom
Clin Cancer Res 13:5070-5. 2007..We sought to determine the prognostic value of the clinically most relevant members of this pathway in colorectal cancer patients... - Upregulation of MICA on high-grade invasive operable breast carcinomaZahra Madjd
Academic Department of Clinical Oncology, Institute of Infections, Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, NG5 1PB, United Kingdom
Cancer Immun 7:17. 2007..Our results suggest that induced expression of MICA may be an indicator of poor prognosis in breast carcinoma and is indicative of a tumour environment that has undergone stresses such as apoptosis, necrosis, or hypoxia... - Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosisNicholas F S Watson
Academic Department of Clinical Oncology, University of Nottingham, City Hospital, Nottingham, United Kingdom
Int J Cancer 118:6-10. 2006..The existence of these poor prognosis tumors, which may avoid both NK- and T-cell-mediated immune surveillance, has important implications for the design of immunotherapeutic strategies in colorectal cancer... - A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55Gustav J Ullenhag
Academic Department of Clinical Oncology, Nottingham City Hospital, Nottingham, United Kingdom
Clin Cancer Res 12:7389-96. 2006..Responses to both the anti-idiotype and the CD55 antigen were measurable, adding support to the use of CD55 as a target in cancer treatment...