Research Topics
Genomes and GenesSpecies | Kate A WardSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Musculoskeletal phenotype through the life course: the role of nutritionKate Ward
MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, UK
Proc Nutr Soc 71:27-37. 2012..In conclusion, a life-course approach is required to understand the definition of healthy skeletal phenotype in different populations and at different stages of life...- Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in menDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
Calcif Tissue Int 89:446-55. 2011..90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men... - Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European menK A Ward
Nutrition and Bone Health, MRC Human Nutrition Research, Fulbourn Road, Cambridge CB1 9NL, UK
Osteoporos Int 22:1513-23. 2011..Age-related change in bone density and geometry was observed. In older men, bioavailable oestradiol may play a role in the maintenance of cortical and trabecular bone mineral density (BMD)... - A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal femalesK A Ward
Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
J Clin Endocrinol Metab 95:4643-51. 2010..There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone mineral accumulation... - Postpartum bone status in teenage mothers assessed using peripheral quantitative computed tomographyKate A Ward
Clinical Radiology, Imaging Sciences Research Group, University of Manchester, St Mary s Hospital, Oxford Road, Manchester M13 9PT, UK
J Clin Densitom 12:219-23. 2009..These data suggest that pregnancy might have a detrimental effect on teenage mothers' future skeletal health. The results of this study require confirmation and provide pilot data for further investigations... - Vitamin D status and muscle function in post-menarchal adolescent girlsKate A Ward
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
J Clin Endocrinol Metab 94:559-63. 2009..There has been a resurgence of vitamin D deficiency among infants, toddlers, and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been widely studied... - The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European menKate L Holliday
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
PLoS ONE 6:e22037. 2011.... - Polymorphisms in genes involved in the NF-?B signalling pathway are associated with bone mineral density, geometry and turnover in menDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
PLoS ONE 6:e28031. 2011.... - A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing StudyDelnaz Roshandel
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
BMC Med Genet 12:19. 2011..The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested... - Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in menDelnaz Roshandel
Arthritis Research UK, Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
J Bone Miner Res 25:1830-8. 2010..02, p = 6.06 x 10(-8)) and higher ultrasound BMD at the calcaneus (beta = 0.01, p = .037). Our findings suggest that genetic variation in the RANKL/RANK/OPG signaling pathway influences bone turnover and BMD in European men... - Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly menStephen R Pye
ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Calcif Tissue Int 86:211-9. 2010..Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men... - Disease activity and severity in early inflammatory arthritis predict hand cortical bone lossStephen R Pye
Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester M13 9PT, UK
Rheumatology (Oxford) 49:1943-8. 2010..To determine the influence of disease-related variables on hand cortical bone loss in women with early inflammatory arthritis (IA), and whether hand cortical bone mass predicts subsequent joint damage... - Bone status during adolescence, pregnancy and lactationKate A Ward
Clinical Radiology, Imaging Science and Biomedical Engineering, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Curr Opin Obstet Gynecol 17:435-9. 2005..This review aims to describe the adaptive mechanisms of the female skeleton to pregnancy and lactation, which ensure optimal fetal skeletal mineralization without compromise to maternal bone strength... - UK reference data for the Hologic QDR Discovery dual-energy x ray absorptiometry scanner in healthy children and young adults aged 6-17 yearsKate A Ward
Department of Clinical Radiology, Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
Arch Dis Child 92:53-9. 2007..Ideally, such data should be matched for sex, chronological age, height, weight, pubertal development and ethnicity... - Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)Kate L Limer
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
J Bone Miner Res 24:314-23. 2009.... - Evidence for enhanced characterization of cortical bone using novel pQCT shape softwareMargaret Ann Laskey
Nutrition and Bone Health, MRC Human Nutrition Research, Cambridge, UK
J Clin Densitom 13:247-55. 2010..Significant differences remained after adjusting for age, height, and weight. In conclusion, shape-sensitive software enhanced the characterization of tibiae in 2 contrasting groups of women...