Research Topics
| Jill P G UrbanSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotypeHeather A Horner
Physiology Laboratory, Oxford University, Oxford, and the; Centre for Spinal Studies, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
Spine 27:1018-28. 2002..Alginate, although an appropriate culture system for inner anulus and nucleus cells, may not be a suitable medium for outer anulus cells...- Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cellsSusan R S Bibby
University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
Spine (Phila Pa 1976) 30:487-96. 2005..In vitro measurements of metabolic rates of isolated bovine nucleus pulposus cells at varying levels of oxygen, glucose, and pH... - Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressureCornelia Neidlinger-Wilke
Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081, Ulm, Germany
Eur Spine J 15:S372-8. 2006..5 MPa) tends to decrease the matrix protein expression with a tendency to increase some matrix-turnover enzymes. Therefore, hydrostatic pressure may regulate disc matrix turnover in a dose-dependent way... - Effect of extracellular ph on matrix synthesis by chondrocytes in 3D agarose gelMin Hsien Wu
Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK
Biotechnol Prog 23:430-4. 2007..Consequently, the control of extracellular pH condition is crucially important for successful cartilage tissue engineering and for the study of chondrocyte physiology and functions... - 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral discH A Horner
Physiology Laboratory, Oxford University, Parks Road, Oxford OX1 3PT, England, United Kingdom
Spine (Phila Pa 1976) 26:2543-9. 2001..Disc cell viability was analyzed in relation to nutrient supply and cellular demand in vitro in a diffusion chamber... - Nutrition of the intervertebral discJill P G Urban
Physiology Laboratory, Oxford University, Oxford, United Kingdom
Spine (Phila Pa 1976) 29:2700-9. 2004..A review of the literature on disc nutrition... - Degeneration of the intervertebral discJill P G Urban
University Laboratory of Physiology, Oxford University, Oxford, UK
Arthritis Res Ther 5:120-30. 2003..New developments, such as genetic and biological approaches, may allow better diagnosis and treatments in the future... - The role of the physicochemical environment in determining disc cell behaviourJ P G Urban
Physiology Laboratory, Oxford University, UK
Biochem Soc Trans 30:858-64. 2002..Here we will briefly review these factors and discuss the influence of changes in the physicochemical environment on cellular activity, in particular on the rate at which disc cells synthesize and degrade matrix macromolecules... - Pathophysiology of the intervertebral disc and the challenges for MRIJill P G Urban
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
J Magn Reson Imaging 25:419-32. 2007.... - Notochordal intervertebral disc cells: sensitivity to nutrient deprivationThorsten Guehring
University of Oxford, Oxford, UK
Arthritis Rheum 60:1026-34. 2009..We undertook this study to test the hypothesis that the consequent nutrient stress could be associated with NC disappearance... - Nutrient gradients in engineered cartilage: metabolic kinetics measurement and mass transfer modelingShengda Zhou
Department of Engineering Science, Oxford University, Parks Road, Oxford OX1 3PJ, UK
Biotechnol Bioeng 101:408-21. 2008..This study provides useful guidance for design of engineered cartilage constructs... - Influence of perfusion on metabolism and matrix production by bovine articular chondrocytes in hydrogel scaffoldsXia Xu
Department of Engineering Science, University of Oxford, Parks Rd, Oxford, OX1 3PJ, United Kingdom
Biotechnol Bioeng 93:1103-11. 2006..It is suggested that the positive effect of perfusion culture only can be achieved by an appropriate choice of other factors such as scaffold materials... - Monitoring of metabolite gradients in tissue-engineered constructsOlga A Boubriak
Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
J R Soc Interface 3:637-48. 2006..Such information during the growth of tissue-engineered constructs would allow either corrective action or else an early end to an unsuccessful test... - Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolitesThijs Grunhagen
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
Orthop Clin North Am 42:465-77, vii. 2011..This article reviews pathways of nutrient supply to these cells; examines factors that may interrupt these pathways, and discusses consequences for disk cell survival, disk degeneration, and disk repair... - The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposusSajjad Razaq
University Laboratory of Physiology, University of Oxford, Parks Road, OX1 3PT, Oxford, UK
Eur Spine J 12:341-9. 2003..The low values of pH seen in some degenerate discs are thus likely to be involved in breakdown of the disc matrix... - Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytesYing Cui
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
Spine (Phila Pa 1976) 35:1101-8. 2010..A comparative in vitro metalloproteinases and their inhibitors gene expression profile... - Functional replacement of oxygen by other oxidants in articular cartilageRobert B Lee
University of Oxford, Oxford, UK
Arthritis Rheum 46:3190-200. 2002..Under physiologic conditions, oxygen acts as this oxidant, but its role can be adequately assumed by other agents... - Cell viability and the physical environment in the scoliotic intervertebral discSusan R S Bibby
Physiology Laboratory, Oxford University, Oxford OX1 3PT, UK
Stud Health Technol Inform 91:419-21. 2002 - The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral discJing Yu
University Laboratory of Physiology, Oxford University, Oxford, United Kingdom
Spine (Phila Pa 1976) 30:1815-20. 2005..Immunohistochemical study of elastic fibers in human intervertebral discs (IVD) collected at surgery from patients with scoliosis... - The elastic network of articular cartilage: an immunohistochemical study of elastin fibres and microfibrilsJing Yu
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
J Anat 216:533-41. 2010.... - Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling studyShengda Zhou
Oxford University, Oxford, UK
Arthritis Rheum 50:3915-24. 2004..Supply from the subchondral bone may be of particular importance... - Nutrient supply and intervertebral disc metabolismThijs Grunhagen
University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom
J Bone Joint Surg Am 88:30-5. 2006..Although gradients cannot be measured easily in humans, they can be calculated. Measured concentrations in surgical patients are in agreement with calculated values... - Measurement of the chondrocyte membrane permeability to Me2SO, glycerol and 1,2-propanediolXia Xu
Department of Engineering Science, Oxford University, Parks Road, OX1 3PJ, Oxford, UK
Med Eng Phys 25:573-9. 2003..The measured parameters can be used to optimise the CPA addition and removal protocols to maximize the cell survival during cryopreservation... - Elastic fibre organization in the intervertebral discs of the bovine tailJing Yu
Laboratory of Physiology, Oxford University, UK
J Anat 201:465-75. 2002..The varying organization of the elastic fibres in the different regions of the disc is likely to relate to the different regional loading patterns... - Study of on-line monitoring of lactate based on optical fibre sensor and in-channel mixing mechanismMin Hsien Wu
Central Microstructure Facility, Rutherford Appleton Laboratory, Oxford, UK
Biomed Microdevices 9:167-74. 2007..Due to the miniaturization of sensing system and micro-scale mixing, higher detection sensitivity (0.15 V/mM) can be realized than the mixing in lab-scale equipments (0.08 V/mM)... - Adaptation of articular chondrocytes to changes in osmolalityBethan Hopewell
University Laboratory of Physiology, Parks Road, Oxford, UK
Biorheology 40:73-7. 2003..These results suggest that osmolality is a powerful regulator of macromolecular synthesis, and that perturbations in the osmotic environment may alter the set point for turnover... - The distribution of fibrillin-2 and LTBP-2, and their co-localisation with fibrillin-1 in adult bovine tail discBing Li
Department of Orthopedics, Tianjin Hospital, Tianjin Medical University, Tianjin, China
J Anat 220:164-72. 2012..However, interestingly LTBP-2 but not fibrillin-1 or fibrillin-2 was removed by hyaluronidase but not collagenase pre-digestion. Our results suggest that fibrillin-2 and LTBP-2 could play an important role in disc function... - Bovine explant model of degeneration of the intervertebral discSally Roberts
Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, UK
BMC Musculoskelet Disord 9:24. 2008..Bovine explant model systems have many advantages but it is not possible to inject any significant volume into an intact disc. Therefore we have attempted to mimic disc degeneration in an explant bovine model via enzymatic digestion... - Development of PDMS microbioreactor with well-defined and homogenous culture environment for chondrocyte 3-D cultureMin Hsien Wu
Department of Engineering Science, University of Oxford, UK
Biomed Microdevices 8:331-40. 2006..As a whole, the proposed culture system is capable of providing a well-defined and homogenous culture environment... - Cell viability in scoliotic discs in relation to disc deformity and nutrient levelsSusan R S Bibby
Laboratory of Physiology, University of Oxford, UK
Spine 27:2220-8; discussion 2227-8. 2002..Cell death is expected eventually to have a deleterious effect on cell matrix and disc function... - A SU-8/PDMS hybrid microfluidic device with integrated optical fibers for online monitoring of lactateMin-Hsien Wu
Department of Engineering Science, University of Oxford, UK
Biomed Microdevices 7:323-9. 2005..The fabrication of device is simple and low cost. The present work has provided some fundamental data for further system optimization to meet specific detection requirements...