Nicholas J Timpson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
    Nicholas J Timpson
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    Lancet 366:1954-9. 2005
  2. ncbi Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children
    Nicholas J Timpson
    Department of Social Medicine, Bristol University, Bristol, UK
    BMC Genet 8:51. 2007
  3. ncbi Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:814-21. 2008
  4. ncbi Adiponectin and its association with bone mass accrual in childhood
    Adrian Sayers
    Academic Rheumatology, School of Clinical Sciences, Bristol, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 25:2212-20. 2010
  5. ncbi How does body fat influence bone mass in childhood? A Mendelian randomization approach
    Nicholas J Timpson
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    J Bone Miner Res 24:522-33. 2009
  6. ncbi Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants
    Nicholas J Timpson
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
    Am J Clin Nutr 92:375-82. 2010
  7. ncbi Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity
    Wiebke Schumacher
    MRC CAiTE Centre, University of Bristol, Bristol, UK
    Hypertension 53:150-7. 2009
  8. ncbi The fat mass- and obesity-associated locus and dietary intake in children
    Nicholas J Timpson
    MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
    Am J Clin Nutr 88:971-8. 2008
  9. ncbi A powerful approach to sub-phenotype analysis in population-based genetic association studies
    Andrew P Morris
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
    Genet Epidemiol 34:335-43. 2010
  10. ncbi Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone
    Lavinia Paternoster
    University of Bristol, Bristol, UK
    PLoS Genet 6:e1001217. 2010

Detail Information

Publications19

  1. ncbi C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
    Nicholas J Timpson
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    Lancet 366:1954-9. 2005
    ..Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free from confounding and reverse causation, to assess the causal role of this protein...
  2. ncbi Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children
    Nicholas J Timpson
    Department of Social Medicine, Bristol University, Bristol, UK
    BMC Genet 8:51. 2007
    ..Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability...
  3. ncbi Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:814-21. 2008
    ..89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression...
  4. ncbi Adiponectin and its association with bone mass accrual in childhood
    Adrian Sayers
    Academic Rheumatology, School of Clinical Sciences, Bristol, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 25:2212-20. 2010
    ..Since these associations were observed before and after puberty, this suggests that setting of adiponectin levels in midchildhood has the potential to exert long-term effects on bone strength and fracture risk...
  5. ncbi How does body fat influence bone mass in childhood? A Mendelian randomization approach
    Nicholas J Timpson
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    J Bone Miner Res 24:522-33. 2009
    ....
  6. ncbi Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants
    Nicholas J Timpson
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
    Am J Clin Nutr 92:375-82. 2010
    ..To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid...
  7. ncbi Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity
    Wiebke Schumacher
    MRC CAiTE Centre, University of Bristol, Bristol, UK
    Hypertension 53:150-7. 2009
    ..Further studies are needed to confirm these findings, particularly in view of the central role CRP has played in cardiovascular disease so far...
  8. ncbi The fat mass- and obesity-associated locus and dietary intake in children
    Nicholas J Timpson
    MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
    Am J Clin Nutr 88:971-8. 2008
    ..A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity...
  9. ncbi A powerful approach to sub-phenotype analysis in population-based genetic association studies
    Andrew P Morris
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
    Genet Epidemiol 34:335-43. 2010
    ....
  10. ncbi Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone
    Lavinia Paternoster
    University of Bristol, Bristol, UK
    PLoS Genet 6:e1001217. 2010
    ..This finding implicates RANKL as a locus containing variation associated with volumetric bone density and provides further insight into the mechanism by which the RANK/RANKL/OPG pathway may be involved in skeletal development...
  11. ncbi Common variants in the region around Osterix are associated with bone mineral density and growth in childhood
    Nicholas J Timpson
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Hum Mol Genet 18:1510-7. 2009
    ..We conclude that genetic variants in the region of Osterix are associated with BMD in children and adults probably through primary effects on growth...
  12. ncbi Mendelian randomization: application to cardiovascular disease
    Nicholas J Timpson
    MRC CAiTE Centre, School of Social and Community Medicine, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK
    Curr Hypertens Rep 14:29-37. 2012
    ..The potential and the possible limitations of this approach within the cardiovascular field are presented in this review...
  13. ncbi Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008
    ..Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age...
  14. ncbi Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  15. ncbi Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  16. ncbi Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
    Debbie A Lawlor
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS Med 5:e33. 2008
    ..If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis...
  17. ncbi Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  18. ncbi A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height...
  19. ncbi Letter by Timpson et al regarding article, "Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level"
    Nicholas J Timpson
    Circulation 114:e256. 2006