Yik Y Teo

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi On the usage of HWE for identifying genotyping errors
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Ann Hum Genet 71:701-3; author reply 704. 2007
  2. ncbi A genotype calling algorithm for the Illumina BeadArray platform
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Bioinformatics 23:2741-6. 2007
  3. ncbi Perturbation analysis: a simple method for filtering SNPs with erroneous genotyping in genome-wide association studies
    Y Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Ann Hum Genet 72:368-74. 2008
  4. ncbi Exploratory data analysis in large-scale genetic studies
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biostatistics 11:70-81. 2010
  5. ncbi Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Curr Opin Lipidol 19:133-43. 2008
  6. ncbi Power consequences of linkage disequilibrium variation between populations
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genet Epidemiol 33:128-35. 2009
  7. ncbi Assessing genuine parents-offspring trios for genetic association studies
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Hered 67:26-37. 2009
  8. ncbi Genome-wide comparisons of variation in linkage disequilibrium
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Genome Res 19:1849-60. 2009
  9. ncbi A novel method for haplotype clustering and visualization
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Genet Epidemiol 34:34-41. 2010
  10. ncbi Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 17:1080-5. 2009

Collaborators

Detail Information

Publications14

  1. ncbi On the usage of HWE for identifying genotyping errors
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Ann Hum Genet 71:701-3; author reply 704. 2007
  2. ncbi A genotype calling algorithm for the Illumina BeadArray platform
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Bioinformatics 23:2741-6. 2007
    ..As the technology moves towards assaying millions of genetic polymorphisms simultaneously, there is a need for an integrated and easy-to-use software for calling genotypes...
  3. ncbi Perturbation analysis: a simple method for filtering SNPs with erroneous genotyping in genome-wide association studies
    Y Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Ann Hum Genet 72:368-74. 2008
    ..SNPs identified by perturbation analysis had lower call and concordance rates, and removal of these SNPs significantly improved the performance for the remaining SNPs...
  4. ncbi Exploratory data analysis in large-scale genetic studies
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biostatistics 11:70-81. 2010
    ..EDA of such large-scale genetic data sets thus requires specialized numerical and graphical strategies, and this article provides a review of the current exploratory tools commonly used in GWAS...
  5. ncbi Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Curr Opin Lipidol 19:133-43. 2008
    ..The present review highlights the statistical challenges associated with such large-scale genetic studies and discusses the available methodological strategies for handling these issues...
  6. ncbi Power consequences of linkage disequilibrium variation between populations
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genet Epidemiol 33:128-35. 2009
    ....
  7. ncbi Assessing genuine parents-offspring trios for genetic association studies
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Hered 67:26-37. 2009
    ..Here, we introduce a method for evaluating the authenticity of nuclear family trios...
  8. ncbi Genome-wide comparisons of variation in linkage disequilibrium
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Genome Res 19:1849-60. 2009
    ....
  9. ncbi A novel method for haplotype clustering and visualization
    Yik Y Teo
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Genet Epidemiol 34:34-41. 2010
    ....
  10. ncbi Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 17:1080-5. 2009
    ..Our results highlight some of the consequences of allelic heterogeneity, particularly the increased type I error. They also suggest that G6PD-deficient male hemizygotes and female heterozygotes are protected from severe malaria...
  11. ncbi Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    ..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
  12. ncbi Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  13. ncbi Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    ..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases...
  14. ncbi Whole genome-amplified DNA: insights and imputation
    Yik Y Teo
    Nat Methods 5:279-80. 2008