Research Topics
Genomes and Genes | Peter W TaylorSummaryAffiliation: University of London Country: UK Publications
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Publications
Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2Patricia Bernal
School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
J Biol Chem 285:24055-65. 2010..We argue that many features of the ECg-induced phenotype can be explained by changes in the fluid dynamics of the CM...- Pharmaceutical quality of generic isotretinoin products, compared with RoaccutanePeter W Taylor
The School of Pharmacy, University of London, London, UK
Curr Med Res Opin 22:603-15. 2006..Several generic products are available. However, their pharmaceutical quality, in particular particle size distribution, which may affect safety and efficacy is unknown. Hence, prescribing of some generic products may be problematic... - New ways to treat bacterial infectionsPeter W Taylor
Department of Pharmaceutics, School of Pharmacy, University of London, 29 39 Brunswick Square, London, UK WC1N 1AX
Drug Discov Today 7:1086-91. 2002.... - Towards rational treatment of bacterial infections during extended space travelPeter W Taylor
Microbiology Group, Department of Pharmaceutics, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
Int J Antimicrob Agents 26:183-7. 2005..We highlight new rationales for the treatment of infectious disease that may be applicable to therapy in extreme environments such as deep space... - Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureusTsveta Hadjivassileva
School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
Int J Antimicrob Agents 29:672-8. 2007..These studies support the premise that the potency of ELB-21 is due to efficient cell penetration and provide evidence that the antibacterial activity of PBD dimers results from cross-linking at specific genomic sites... - Anti-Staphylococcus aureus activity and oxacillin resistance modulating capacity of 3-O-acyl-catechinsPaul D Stapleton
Microbiology Group, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
Int J Antimicrob Agents 24:374-80. 2004..3-O-acyl catechins tested at a 1/4 MIC did not reduce the oxacillin MIC greater than two-fold. 3-O-acyl catechins warrant further investigation as anti-staphylococcal agents... - Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1Andrea Zelmer
School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
Microbiology 156:2205-15. 2010..coli K1 virulence by removal of the polySia capsule may minimize the attendant inflammatory processes that contribute to poor outcome in these severe systemic infections... - Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimerMarie Doyle
School of Pharmacy, University of London, London, UK
J Antimicrob Chemother 64:949-59. 2009..Transcriptional and proteomic alterations induced by exposure of Staphylococcus aureus clinical isolate EMRSA-16 to ELB-21 were determined in order to define more precisely the bactericidal mechanism of the drug... - Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechinsPaul D Stapleton
Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom
Antimicrob Agents Chemother 50:752-5. 2006..EC and EGC significantly increased the capacity of ECg and EGCg to reduce levels of staphylococcal oxacillin resistance... - Epicatechin gallate, a component of green tea, reduces halotolerance in Staphylococcus aureusPaul D Stapleton
Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom
Int J Food Microbiol 111:276-9. 2006..The capacity of ECg to suppress staphylococcal growth in the presence of salt suggests that this molecule could be used to aid the preservation of salt-containing foods... - The beta-lactam-resistance modifier (-)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureusPaul D Stapleton
Microbiology Group, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
Microbiology 153:2093-103. 2007..Thus, ECg-mediated alterations to the physical nature of the bilayer will elicit structural changes to WTA that result in modulation of the cell-surface properties necessary to maintain the beta-lactam-resistant phenotype... - The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureusHelena Rosado
School of Pharmacy, University of London, London, UK
J Antimicrob Chemother 66:985-96. 2011..We determined the DNA sequence preferences of ELB-21 in relation to its capacity to exert a bactericidal effect by damaging DNA... - Disruption of D-alanyl esterification of Staphylococcus aureus cell wall teichoic acid by the {beta}-lactam resistance modifier (-)-epicatechin gallatePatricia Bernal
University of London, Brunswick Square, UK
J Antimicrob Chemother 63:1156-62. 2009..Decreased susceptibility to lysostaphin suggests alterations to the wall teichoic acid (WTA) content of ECg-grown bacteria. Changes in WTA structure in response to ECg were determined... - Pharmaceutical quality of nine generic orlistat products compared with Xenical(r)Peter W Taylor
Department of Pharmaceutics, London School of Pharmacy, London, UK
Obes Facts 3:231-7. 2010..To compare the pharmaceutical quality of Xenical (chemically produced orlistat) with nine generic products, each produced by fermentation processes... - Methicillin resistance in Staphylococcus aureus: mechanisms and modulationPaul D Stapleton
School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX
Sci Prog 85:57-72. 2002.... - Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1Andrea Zelmer
School of Pharmacy, 29 39 Brunswick Square, London, UK
Microbiology 154:2522-32. 2008..Thus, systemic infections due to encapsulated pathogens may be resolved by capsule depolymerization only if the enzyme modifies the bacteria whilst they are in the blood compartment... - In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteriaVeronique Seidel
Microbiology Group, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
Int J Antimicrob Agents 23:613-9. 2004..The most potent compound was linoleic acid, with MIC of 2 mg/l against M. aurum... - Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteriaTsveta Hadjivassileva
School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK
J Antimicrob Chemother 56:513-8. 2005..CONCLUSIONS: These data indicate that this novel class of antibacterial agents warrants further investigation as potential antibiotics for the treatment of severe infections caused by Gram-positive pathogens... - Anti-staphylococcal activity and ?-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallateJames C Anderson
Department of Chemistry, University College London, London, UK
Bioorg Med Chem Lett 21:6996-7000. 2011..25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity... - Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymeraseNaseem Mushtaq
Microbiology Group, School of Pharmacy, London, UK
J Antimicrob Chemother 56:160-5. 2005..Thus, whilst endoE-mediated therapy may not be a viable approach to the treatment of systemic infection in humans, it does support the concept that alteration of the cell wall phenotype is a valid therapeutic strategy... - Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallatesPaul D Stapleton
Microbiology Group, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK
Int J Antimicrob Agents 23:462-7. 2004..Consequently, EGCG, CG and, particularly, ECG warrant further investigation as agents to combat beta-lactam resistance in S. aureus... - Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotypeNaseem Mushtaq
Microbiology Group, School of Pharmacy, London WC1N 1AX, United Kingdom
Antimicrob Agents Chemother 48:1503-8. 2004..This study demonstrates the potential therapeutic efficacy of agents that cure infections by modification of the bacterial phenotype rather than by killing or inhibition of growth of the pathogen... - Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureusJames C Anderson
School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK
Bioorg Med Chem Lett 15:2633-5. 2005.... - Expression, mutagenesis and kinetic analysis of recombinant K1E endosialidase to define the site of proteolytic processing and requirements for catalysisDaniel R Leggate
Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, UK
Mol Microbiol 44:749-60. 2002.... - Single-blind randomized trial of combination antibiotic therapy in rheumatoid arthritisLuke L Gompels
Kennedy Institute of Rheumatology, Charing Cross Hospital, London, England
J Rheumatol 33:224-7. 2006..CONCLUSION: Combined antibiotic therapy with intravenous clindamycin and oral tetracycline may be useful in the management of active RA. A double-blind, placebo-controlled trial of therapy is justified...