Roland H Stimson

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 92:4480-4. 2007
  2. ncbi Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
    R H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Minerva Endocrinol 32:141-59. 2007
  3. ncbi Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans
    Roland H Stimson
    Endocrinology Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 58:46-53. 2009
  4. ncbi Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats
    Roland H Stimson
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8779. 2010
  5. ncbi Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 60:720-5. 2011
  6. ncbi Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men
    Deborah J Wake
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, United Kingdom
    J Clin Endocrinol Metab 92:1848-56. 2007
  7. ncbi Salicylate downregulates 11?-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
    Mark Nixon
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, U K
    Diabetes 61:790-6. 2012

Detail Information

Publications7

  1. ncbi Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 92:4480-4. 2007
    ..However, whether longer-term differences in dietary macronutrients affect cortisol metabolism in humans and contribute to the tissue-specific dysregulation of cortisol metabolism in obesity is unknown...
  2. ncbi Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome
    R H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Minerva Endocrinol 32:141-59. 2007
    ..Trials in humans though will be the ultimate test to determine if inhibition of 11beta-HSD1 offers a new tool in the treatment of metabolic disease...
  3. ncbi Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans
    Roland H Stimson
    Endocrinology Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 58:46-53. 2009
    ..Inhibition of 11beta-HSD1 is a promising therapeutic approach in type 2 diabetes. However, release of cortisol by 11beta-HSD1 from adipose tissue and its effect on portal vein cortisol concentrations have not been quantified in vivo...
  4. ncbi Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats
    Roland H Stimson
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8779. 2010
    ....
  5. ncbi Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition
    Roland H Stimson
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Diabetes 60:720-5. 2011
    ..To examine this, we quantified in vivo whole-body, splanchnic, and hepatic 11?-HSD1 activity in obese type 2 diabetic subjects...
  6. ncbi Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men
    Deborah J Wake
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, United Kingdom
    J Clin Endocrinol Metab 92:1848-56. 2007
    ....
  7. ncbi Salicylate downregulates 11?-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization
    Mark Nixon
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland, U K
    Diabetes 61:790-6. 2012
    ..Reduced intra-adipose glucocorticoid regeneration by 11?-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates...