Grant S Stewart

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi MDC1 is a mediator of the mammalian DNA damage checkpoint
    Grant S Stewart
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 421:961-6. 2003
  2. ncbi Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
    Tatjana Stankovic
    University of Birmingham, CRC Institute for Cancer Studies, The Medical School, Edgbaston, United Kingdom
    Blood 99:300-9. 2002
  3. ncbi Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias
    Jane Starczynski
    Department of Histopathology, Birmingham Heartland s Hospital, Birmingham, United Kingdom
    Am J Pathol 163:423-32. 2003
  4. ncbi Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses
    Tatjana Stankovic
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Blood 103:291-300. 2004
  5. ncbi Solving the RIDDLE of 53BP1 recruitment to sites of damage
    Grant S Stewart
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK
    Cell Cycle 8:1532-8. 2009
  6. ncbi RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
    Grant S Stewart
    Cancer Research UK, Institute for Cancer Studies, Birmingham University, Vincent Drive, Edgbaston, Birmingham, United Kingdom
    Proc Natl Acad Sci U S A 104:16910-5. 2007
  7. ncbi The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
    Grant S Stewart
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK
    Cell 136:420-34. 2009
  8. ncbi Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation
    Andrew N Blackford
    School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:12251-6. 2010
  9. ncbi Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection
    Natalie A Forrester
    University of Birmingham, Birmingham B15 2TT, UK
    J Virol 85:2201-11. 2011
  10. ncbi Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression
    Kelly Townsend
    Cancer Research United Kingdom Institute for Cancer Sciences, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 284:33939-48. 2009

Collaborators

Detail Information

Publications17

  1. ncbi MDC1 is a mediator of the mammalian DNA damage checkpoint
    Grant S Stewart
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 421:961-6. 2003
    ..These results highlight a crucial role for MDC1 in mediating transduction of the DNA damage signal...
  2. ncbi Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
    Tatjana Stankovic
    University of Birmingham, CRC Institute for Cancer Studies, The Medical School, Edgbaston, United Kingdom
    Blood 99:300-9. 2002
    ....
  3. ncbi Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias
    Jane Starczynski
    Department of Histopathology, Birmingham Heartland s Hospital, Birmingham, United Kingdom
    Am J Pathol 163:423-32. 2003
    ..As a result, immunostaining to identify lymphoid neoplasias with ATM inactivation might only be feasible for tumors derived from the stages where ATM is constitutively highly expressed...
  4. ncbi Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses
    Tatjana Stankovic
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Blood 103:291-300. 2004
    ..Therefore, damage-induced transcriptional fingerprinting can be used to stratify tumors according to their biologic differences and simultaneously identify potential targets for treating refractory tumors...
  5. ncbi Solving the RIDDLE of 53BP1 recruitment to sites of damage
    Grant S Stewart
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK
    Cell Cycle 8:1532-8. 2009
    ....
  6. ncbi RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
    Grant S Stewart
    Cancer Research UK, Institute for Cancer Studies, Birmingham University, Vincent Drive, Edgbaston, Birmingham, United Kingdom
    Proc Natl Acad Sci U S A 104:16910-5. 2007
    ..Therefore, these data indicate the existence of a DNA double-strand break-repair protein that functions upstream of 53BP1 and contributes to the normal development of the human immune system...
  7. ncbi The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
    Grant S Stewart
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK
    Cell 136:420-34. 2009
    ..These RNF168-dependent chromatin modifications orchestrate the accumulation of 53BP1 and BRCA1 to DNA lesions, and their loss is the likely cause of the cellular and developmental phenotypes associated with RIDDLE syndrome...
  8. ncbi Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation
    Andrew N Blackford
    School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:12251-6. 2010
    ..Taken together, these data provide insights into how Ad modulates ATR signaling pathways during infection...
  9. ncbi Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection
    Natalie A Forrester
    University of Birmingham, Birmingham B15 2TT, UK
    J Virol 85:2201-11. 2011
    ..We suggest that group B and D adenoviruses have evolved mechanisms based on the loss of DNA ligase IV and perhaps other unknown molecules to disable the host cell DNA damage response to promote viral replication...
  10. ncbi Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression
    Kelly Townsend
    Cancer Research United Kingdom Institute for Cancer Sciences, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 284:33939-48. 2009
    ..We suggest therefore that hMDC1 functionally regulates the normal metaphase-to-anaphase transition by modulating the Cdc20-dependent activation of the APC/C...
  11. ncbi A role for E1B-AP5 in ATR signaling pathways during adenovirus infection
    Andrew N Blackford
    CR UK Institute for Cancer Studies, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 82:7640-52. 2008
    ..This might have broader implications for the regulation of ATR activity during cellular DNA replication or in response to DNA damage...
  12. ncbi Adenovirus E4orf3 targets transcriptional intermediary factor 1? for proteasome-dependent degradation during infection
    Natalie A Forrester
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UnitedKingdom
    J Virol 86:3167-79. 2012
    ..Taken together, these studies have identified novel adenovirus targets and have established a new role for the E4orf3 protein during infection...
  13. ncbi DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome
    Rachel M Blundred
    School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK
    Expert Rev Clin Immunol 7:169-85. 2011
    ..We also consider the implications of this finding on the mechanisms controlling development of the immune system...
  14. ncbi The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression
    Andrew S Turnell
    Cancer Research UK Institute for Cancer Studies, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nature 438:690-5. 2005
    ..Taken together, our results define discrete roles for the APC/C-CBP/p300 complexes in growth regulation...
  15. ncbi A PIAS-ed view of DNA double strand break repair focuses on SUMO
    Anastasia Zlatanou
    School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands B15 2TT, UK
    DNA Repair (Amst) 9:588-92. 2010
    ..Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage...
  16. ncbi Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
    Christoph Spycher
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    J Cell Biol 181:227-40. 2008
    ..Thus, our data reveal the mechanism by which MDC1 physically couples the MRN complex to damaged chromatin...
  17. ncbi Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    Shiaw Yih Lin
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6484-9. 2004
    ..These results suggest that Claspin has properties of both a tumor suppressor and an oncogene...