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Species | F SpigaSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretionF Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
J Neuroendocrinol 19:891-900. 2007..In light of the evidence showing an involvement of dysfunctional HPA axis in the pathophysiology of depression, Org 34850 could be a potential treatment for mood disorders...- ACTH-dependent ultradian rhythm of corticosterone secretionFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
Endocrinology 152:1448-57. 2011..Because constant infusion of identical amounts of ACTH did not activate CORT secretion, pulsatility of ACTH provides a more effective signaling system for the activation of adrenocortical activity... - Temporal effect of adrenocorticotrophic hormone on adrenal glucocorticoid steroidogenesis: involvement of the transducer of regulated cyclic AMP-response element-binding protein activityF Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
J Neuroendocrinol 23:136-42. 2011..The delayed induction of SIK1 suggests a role for SIK1 in the declining phase of steroidogenesis... - Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA bindingFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
J Psychopharmacol 25:211-21. 2011.... - Dose-dependent effects of corticosterone on nuclear glucocorticoid receptors and their binding to DNA in the brain and pituitary of the ratFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
Brain Res 1293:101-7. 2009..These data have important implications for our understanding of tissue specificity of glucocorticoid action including the corticosteroid-mediated negative feed-back response of the HPA axis... - Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressorFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
J Endocrinol 200:285-91. 2009..Pretreatment with Org reduced the exaggerated ACTH response to noise after both single and repeated exposure to restraint... - Blockade of the V(1b) receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activityFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
J Endocrinol 200:273-83. 2009..Our results confirm that this compound is an antagonist of the V(1b)R in the rat, and that its ability to reduce stress-induced ACTH responses is stressor dependent with differential modulation of pituitary and adrenal responses... - Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone releaseFrancesca Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
J Endocrinol 196:323-30. 2008..Our data suggest an involvement of GR in modulating delayed, but not fast, inhibition induced by MPL on basal corticosterone secretion... - Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleusJ Adriaan Bouwknecht
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
Brain Res Bull 72:32-43. 2007.... - A glucocorticoid sensitive biphasic rhythm of testosterone secretionE Waite
University of Bristol, UK
J Neuroendocrinol 21:737-41. 2009..Thus, although the circadian rhythm of testosterone does not depend on normal HPA function, increased levels of glucocorticoids can abolish normal HPT rhythmicity... - The significance of glucocorticoid pulsatilityStafford L Lightman
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
Eur J Pharmacol 583:255-62. 2008..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor... - Exposure to high- and low-light conditions in an open-field test of anxiety increases c-Fos expression in specific subdivisions of the rat basolateral amygdaloid complexMatthew W Hale
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol, BS1 3NY, United Kingdom
Brain Res Bull 71:174-82. 2006.... - Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleusDaniel R Staub
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Brain Res 1044:176-89. 2005.... - Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neuronsF Spiga
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK
Neuroscience 138:1265-76. 2006..These results are consistent with the hypothesis that the basolateral amygdala and serotonergic neurons within the midbrain raphe complex are part of an integrated neural system modulating anxiety state...