Research Topics
| Colette J SmithSummaryAffiliation: University College London Country: UK Publications
| Collaborators
|
Detail Information
Publications
The problems faced when assessing the prevalence and incidence of antiretroviral-related toxicitiesColette J Smith
Department of Primary Care and Population Sciences and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
Antivir Ther 9:865-78. 2004..We investigated the possible explanations for the differences in the incidence and prevalence rates of HAART-related toxicities between studies, focussing on metabolic and hepatotoxic disorders...- The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapyColette J Smith
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
AIDS 17:963-9. 2003..To study the long-term CD4 cell responses to highly active antiretroviral therapy (HAART) in treatment-naive patients whose viral loads remained below 500 copies/ml for prolonged periods... - Response to efavirenz-containing regimens in previously antiretroviral-naive HIV-positive patients: the role of genderColette J Smith
HIV Biostatistics and Epidemiology Group and Department of Primary Care and Population Science, Royal Free and University College Medical School, London, United Kingdom
J Acquir Immune Defic Syndr 46:62-7. 2007..We investigated the role of gender on response to efavirenz (EFV)-containing regimens in previously antiretroviral-naive patients... - The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA studyColette J Smith
Royal Free and University College Medical School, London, UK
AIDS 22:47-56. 2008..This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine... - Factors associated with viral rebound among highly treatment-experienced HIV-positive patients who have achieved viral suppressionC J Smith
Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
HIV Med 10:19-27. 2009..More and more highly treatment-experienced patients are achieving viral suppression. However, the durability of suppression remains unclear... - The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: results from a multicenter cohort studyColette J Smith
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
J Infect Dis 192:1387-97. 2005.... - The relationship between CD4 cell count nadirs and the toxicity profiles of antiretroviral regimensJ Smith Colette
Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, London, UK
Antivir Ther 10:459-67. 2005..We investigated the relationship between the pre-HAART CD4 count nadir, HAART and the occurrence of laboratory-defined toxicities... - Use of viral load measured after 4 weeks of highly active antiretroviral therapy to predict virologic outcome at 24 weeks for HIV-1-positive individualsColette J Smith
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
J Acquir Immune Defic Syndr 37:1155-9. 2004..We suggest that this group of patients should be particularly closely monitored... - Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK populationC J Smith
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
HIV Med 5:88-92. 2004..We sought to characterize the risk factors for cardiovascular disease present in an HIV-positive population... - Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapyColette J Smith
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
J Infect Dis 190:1860-8. 2004..We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART... - Stability of antiretroviral regimens in patients with viral suppressionRebecca K Lodwick
Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College Medical School, London, UK
AIDS 22:1039-46. 2008..To study the rate of treatment change due to toxicities in patients who achieved viral suppression within 6 months of starting antiretroviral therapy and who have never experienced virological failure... - Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markersCaroline A Sabin
Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Pond St, London, UK
AIDS 20:67-71. 2006..To describe the characteristics of deaths that occur among HIV-positive individuals in the HAART era... - Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapyAnna Maria Geretti
Department of Virology, Royal Free Hampstead NHS Trust, London, UK
J Acquir Immune Defic Syndr 52:569-73. 2009..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)... - Late presenters in the era of highly active antiretroviral therapy: uptake of and responses to antiretroviral therapyCaroline A Sabin
Royal Free and University College Medical School, Royal Free NHS Trust, London, UK
AIDS 18:2145-51. 2004..To investigate the characteristics and clinical, immunological and virological outcomes for individuals presenting for care with low CD4 cell counts... - Success of clinical care for human immunodeficiency virus infection according to demographic group among sexually infected patients in a routine clinic population, 1999 to 2004Fiona C Lampe
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, Rowland Hill Street, London, England
Arch Intern Med 167:692-700. 2007..The success of clinical care for human immunodeficiency virus infection may vary across demographic groups, because of patient- and health care-related factors... - Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletionAndrew N Phillips
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free Campus, UCL Royal Free Campus, London, UK
AIDS 24:1561-7. 2010..Understanding of the interplay between plasma HIV RNA level and CD4 cell count depletion in untreated infection remains incomplete... - Physical and psychological symptoms and risk of virologic rebound among patients with virologic suppression on antiretroviral therapyFiona C Lampe
Department of Infection and Population Health, University College London Medical School, London, UK
J Acquir Immune Defic Syndr 54:500-5. 2010..We examined the association of self-reported physical and psychological symptoms with subsequent virologic rebound among patients with viral suppression on combination antiretroviral therapy (cART)... - Long-term trends in adherence to antiretroviral therapy from start of HAARTValentina Cambiano
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
AIDS 24:1153-62. 2010..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)... - Projected life expectancy of people with HIV according to timing of diagnosisFumiyo Nakagawa
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
AIDS 26:335-43. 2012..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to assess the effect of late diagnosis on life expectancy... - Does immune reconstitution syndrome promote active tuberculosis in patients receiving highly active antiretroviral therapy?Ronan A M Breen
Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK
AIDS 19:1201-6. 2005..To assess whether highly active anti-retroviral therapy (HAART) contributes to the presentation of active tuberculosis (TB)... - How good are systemic symptoms and blood inflammatory markers at detecting individuals with tuberculosis?R A M Breen
Department of Thoracic Medicine, Royal Free Hospital, London, UK
Int J Tuberc Lung Dis 12:44-9. 2008..The diagnosis of tuberculosis (TB) may be rejected in the absence of symptoms such as fever, sweats or weight loss... - Effect of specific ART drugs on lipid changes and the need for lipid management in children with HIVMargaret P Rhoads
Imperial College London, London, United Kingdom
J Acquir Immune Defic Syndr 57:404-12. 2011..We investigated the effects of individual antiretrovirals on lipids in HIV-infected children and the proportion potentially eligible for dietary or pharmacologic intervention... - Rapid diagnosis of smear-negative tuberculosis using immunology and microbiology with induced sputum in HIV-infected and uninfected individualsRonan A M Breen
Department of Immunology, Royal Free and University College Medical School, London, United Kingdom
PLoS ONE 2:e1335. 2007..Until now this has only been possible using the expensive and invasive technique of broncho-alveolar lavage. We sought to evaluate an immunoassay using non-invasive induced-sputum to diagnose active tuberculosis... - Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infectionR A M Breen
Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
Thorax 59:704-7. 2004..It has been suggested that deterioration of tuberculosis (TB) during appropriate treatment, termed a paradoxical reaction (PR), is more common and severe in HIV positive individuals on highly active antiretroviral therapy (HAART)... - Treatment outcomes amongst previously antiretroviral-naïve HIV-infected patients starting lopinavir/ritonavir-containing antiretroviral regimens at the Royal Free HospitalC J Smith
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London, UK
HIV Med 8:55-63. 2007..To describe outcomes in patients starting first-line antiretroviral regimens including lopinavir/ritonavir (LPV/r) in a routine clinic setting... - The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapyC A Sabin
Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
HIV Med 10:35-43. 2009.... - Haemoglobin and albumin as markers of HIV disease progression in the highly active antiretroviral therapy era: relationships with genderS Shah
Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School and Royal Free Hospital, Rowland Hill Street, London, UK
HIV Med 8:38-45. 2007..The aims of the study were to describe gender differences in haemoglobin and albumin and to investigate the prognostic value of these measurements in relation to highly active antiretroviral therapy (HAART)... - No association between HIV disease and its treatment and thyroid functionS Madge
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill Street, London, UK
HIV Med 8:22-7. 2007.... - Adverse events and treatment interruption in tuberculosis patients with and without HIV co-infectionR A M Breen
Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK
Thorax 61:791-4. 2006..A study was undertaken to assess the frequency of serious (grade III/IV) adverse events and interruption of anti-TB treatment in the era of effective antiretroviral therapy... - Use of a prescription-based measure of antiretroviral therapy adherence to predict viral rebound in HIV-infected individuals with viral suppressionV Cambiano
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
HIV Med 11:216-24. 2010..The aim of the study was to assess whether a simple, routinely available measure of antiretroviral therapy (ART) adherence predicts viral rebound at the next HIV viral load (VL) measurement in virally suppressed patients... - Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapyRonan A M Breen
Department of HIV Medicine, Royal Free Hospital, and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
J Infect Dis 193:1437-40. 2006..Tuberculosis recurrence rates were similar to those found in an HIV-uninfected population of 156 subjects (3% and 1%, respectively). Treatment for HIV and tuberculosis does not compromise outcomes for either disease... - An audit of viral load in one clinical population to describe features of viraemic patients on antiretroviral therapyS Madge
Royal Free Centre for HIV Medicine, Royal Free and University College London Medical School, London, UK
HIV Med 9:208-13. 2008..To assess the prevalence of an undetectable viral load (VL) (<50 HIV-1 RNA copies/mL) in a clinical population and to identify those viraemic and at risk of failing antiretroviral therapy (ART)... - Cervical intraepithelial neoplasia treatment in Human Immunodeficiency Virus-positive womenS Shah
Department of Primary Care, Royal Free and University College Medical Schools, London, UK
J Obstet Gynaecol 28:327-32. 2008..Additionally, there is often incomplete clearance of CIN at the resection margins emphasing the need for close follow-up after surgery... - Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertensionChristopher J Valerio
The National Pulmonary Hypertension Unit, Royal Free Hospital, London, UK
Rheumatology (Oxford) 49:2147-53. 2010.... - The relationships of ABCB1 3435C>T and CYP2B6 516G>T with high-density lipoprotein cholesterol in HIV-infected patients receiving EfavirenzT W Mahungu
Department of HIV Medicine, Royal Free NHS Trust, London, UK
Clin Pharmacol Ther 86:204-11. 2009..20 mmol/l, group 1 +0.47 mmol/l, group 2 +1.00 mmol/l; P(ANOVA) < 0.0001). These findings need to be validated in independent cohorts... - Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertensionMark H Williams
Department of Cardiology, Royal Free Hospital, London, UK
Eur Heart J 27:1485-94. 2006..Baseline and serial changes in N-TproBNP levels are highly predictive of survival. A 10-fold increase in N-TproBNP level on therapy is associated with a greater than three-fold increase in mortality, and may indicate therapeutic failure... - The use and abuse of hypothesis tests: how to present P valuesC J Smith
Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
Phlebology 25:107-12. 2010.... - Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosisR A M Breen
Department of Immunology, Royal Free and University College Medical School, London, UK
Thorax 63:67-71. 2008..Lung sampling enables combined microbiological and immunological testing and uses higher frequency antigen-specific responses than in blood... - Systemic sclerosis associated pulmonary hypertension: improved survival in the current eraM H Williams
Department of Cardiology, Royal Free Hospital, London, UK
Heart 92:926-32. 2006..In contrast to patients treated historically with basic drugs and prostanoids, patients treated in the current treatment era had improved survival associated with a lack of deterioration in cardiac haemodynamic function... - Incidence of pancreatitis in HIV-infected patients, and the association with antiretroviral therapyColette J Smith
AIDS 22:997-8. 2008 - HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004Rana Chakraborty
Paediatric Infectious Diseases Unit, St George s Hospital, London
Pediatr Infect Dis J 27:457-9. 2008..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...