Research Topics
| D J SkeneSummaryAffiliation: University of Surrey Country: UK Publications
| Collaborators
|
Detail Information
Publications
Circadian rhythm sleep disorders in the blind and their treatment with melatoninDebra J Skene
Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
Sleep Med 8:651-5. 2007..If practicable, assessment of an individual's circadian phase (by measurement of the endogenous melatonin rhythm in plasma, saliva or urine) is recommended prior to commencing treatment to optimise melatonin's effectiveness...- Human circadian rhythms: physiological and therapeutic relevance of light and melatoninDebra J Skene
Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
Ann Clin Biochem 43:344-53. 2006.... - Melatonin as a chronobioticJosephine Arendt
School of Biomedical and Molecular Sciences, Centre for Chronobiology, University of Surrey, Guildford, Surrey GU2 7XH, UK
Sleep Med Rev 9:25-39. 2005..No long-term safety data exist, and the optimum dose and formulation for any application remains to be clarified... - Optimization of light and melatonin to phase-shift human circadian rhythmsD J Skene
Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
J Neuroendocrinol 15:438-41. 2003..Whether other nonvisual light responses (e.g. circadian phase resetting) show a similar spectral sensitivity is currently being studied... - Melatonin rhythmicity: effect of age and Alzheimer's diseaseDebra J Skene
School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
Exp Gerontol 38:199-206. 2003..Future research needs to pinpoint the site(s) of age-related dysfunction so that therapies can be specifically tailored to correct the abnormality in addition to reinforcing any of the intact processes... - Use of melatonin in the treatment of phase shift and sleep disordersD J Skene
School of Biological Sciences, University of Surrey, Guildford, U K
Adv Exp Med Biol 467:79-84. 1999..Compared with placebo, melatonin advanced the sleep period in subjects with DSPS. Melatonin also improved a number of sleep parameters in blind subjects suffering from non-24-hour sleep wake disorder... - Melatonin in circadian sleep disorders in the blindD J Skene
School of Biological Sciences, University of Surrey, Guildford, UK
Biol Signals Recept 8:90-5. 1999..The results suggest that prior knowledge of the subject's type of circadian rhythm, and timing of treatment in relation to the individual's circadian phase, may improve the efficacy of melatonin... - Use of melatonin in circadian rhythm disorders and following phase shiftsD J Skene
School of Biological Sciences, University of Surrey, Guildford, UK
Acta Neurobiol Exp (Wars) 56:359-62. 1996..Taken together these findings suggest that melatonin is of benefit in facilitating adaptation to forced phase shifts and in conditions of circadian rhythm disturbance... - Effects of light on human circadian rhythmsD J Skene
School of Biological Sciences, University of Surrey, Guildford, UK
Reprod Nutr Dev 39:295-304. 1999..Thus, ocular light appears to be the predominant time cue and major determinant of circadian rhythm type. Optimisation of the light for entrainment (intensity, duration, wavelength, time of administration) requires further study... - Relationship between melatonin rhythms and visual loss in the blindS W Lockley
Chronobiology Laboratory, School of Biological Sciences, University of Surrey, United Kingdom
J Clin Endocrinol Metab 82:3763-70. 1997..6 +/- 0.4 and 0.5 +/- 0.3 microgram/h, respectively). These results indicate that a higher proportion of NPL subjects have abnormal melatonin rhythms compared to those with LP... - Sleep and activity rhythms are related to circadian phase in the blindS W Lockley
School of Biological Sciences, University of Surrey, Guildford, UK
Sleep 22:616-23. 1999..The aim of the study was to assess sleep with simultaneous measurement of an endogenous marker of the circadian clock, namely 6-sulphatoxymelatonin (aMT6s)... - Comparison between subjective and actigraphic measurement of sleep and sleep rhythmsS W Lockley
School of Biological Sciences, University of Surrey, Guildford, UK
J Sleep Res 8:175-83. 1999..In particular, the methods agreed when assessing changes in sleep in relation to a circadian phase marker (the 6-sulphatoxymelatonin (aMT6s) rhythm) in both entrained (n = 30) and free-running (n = 4) subjects... - An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humansK Thapan
Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
J Physiol 535:261-7. 2001..74). 5. Our data strongly support a primary role for a novel short-wavelength photopigment in light-induced melatonin suppression and provide the first direct evidence of a non-rod, non-cone photoreceptive system in humans... - Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin productionJ Nicholls
School of Biological Sciences, University of Surrey, Guildford, United Kingdom
J Pineal Res 23:164-8. 1997..These results are consistent with activation by NECA of an A2b adenosine receptor... - Suppression of nocturnal plasma melatonin and 6-sulphatoxymelatonin by bright and dim light in manC J Bojkowski
Department of Biochemistry, University of Surrey, Guildford, England
Horm Metab Res 19:437-40. 1987..05, P less than 0.01), 0130 h (P less than 0.01, P less than 0.01) and 0200 h (P less than 0.01, P less than 0.001) respectively.(ABSTRACT TRUNCATED AT 250 WORDS).. - Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditionsJ F Walters
Neuroendocrinology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, England
Chronobiol Int 22:859-72. 2005..In conclusion, under controlled experimental conditions the timing of the melatonin rhythm was advanced in postmenopausal women altering its phase relationship to subjective alertness and sleepiness... - Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slicesD J Skene
School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
J Pineal Res 31:333-42. 2001..Collectively, all the above data provide strong experimental evidence that CYP1A2 is an important catalyst of the 6-hydroxylation of melatonin...