Research Topics
| A SimpsonSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Prevention of allergic sensitization by environmental controlAngela Simpson
University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Second Floor, Education and Research Centre, Manchester, United Kingdom
Curr Allergy Asthma Rep 9:363-9. 2009....- The role of lipopolysaccharide in the development of atopy in humansA Simpson
Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK
Clin Exp Allergy 40:209-23. 2010.... - Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort studyAngela Simpson
The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
Am J Respir Crit Care Med 181:1200-6. 2010..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy... - Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and dog allergenA Simpson
North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
Clin Exp Allergy 33:1183-9. 2003..As part of a primary prevention of asthma study, we measured the effect of environmental control measures on Der p 1, Fel d 1 and Can f 1 over a 3.5-year period... - Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort studyS Marinho
University of Manchester, Academic Division of Medicine and Surgery, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
Allergy 62:385-93. 2007..There is a paucity of data on the prevalence, risk factors and natural history of rhinitis in early childhood... - Dust mite allergens are carried on not only large particlesA Custovic
North West Lung Center, Wythenshawe Hospital, Manchester, UK
Pediatr Allergy Immunol 10:258-60. 1999..A small, but potentially significant proportion of this airborne allergen is associated with small particles which, when inhaled, may penetrate deep into the human respiratory tract... - Decreased prevalence of sensitization to cats with high exposure to cat allergenA Custovic
North West Lung Centre, Wythenshawe Hospital, Manchester, United Kingdom
J Allergy Clin Immunol 108:537-9. 2001..0, P =.03; 5th centile, OR 2.2, 95% CI 1.2-4.3, P =.04, 6th centile, OR 2.5, 95% CI 1.3-4.9, P =.005). These results indicate that the prevalence of sensitization to cat is decreased in the lowest and highest cat allergen exposure groups... - Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trialA Custovic
North West Lung Centre, Wythenshawe Hospital, M23 9LT, Manchester, UK
Lancet 358:188-93. 2001..Further follow up is needed, however, to ascertain whether living in a low-allergen environment reduces allergy and asthma in later life... - Household characteristics and allergen and endotoxin levels in Aleppo, Syrian Arab RepublicW Al Ali
North West Lung Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
East Mediterr Health J 16:717-24. 2010..6). Cockroach allergen Bla g 2 was significantly more likely to be detected in houses over 20 years old than newer houses. Endotoxin levels were significantly higher in wool/cotton mattresses and older houses... - Modelling air pollution for epidemiologic research--Part I: A novel approach combining land use regression and air dispersionA Molter
Centre for Occupational and Environmental Health, School of Community Based Medicine, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
Sci Total Environ 408:5862-9. 2010..33, NO(2): R²=0.62; measured data: PM(10): R²=0.56, NO(2): R²=0.86). The validation further showed low mean prediction errors and root mean squared errors for both models... - Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort studyS Marinho
Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK
Allergy 62:1379-86. 2007..Atopy quantification using IgE levels/skin test diameter (SPT-MWD) may better predict the expression of rhinitis than using atopy as a dichotomous variable... - Synthetic pillows contain higher levels of cat and dog allergen than feather pillowsA Custovic
North West Lung Centre, Wythenshawe Hospital, Manchester, UK
Pediatr Allergy Immunol 11:71-3. 2000..01). We have therefore demonstrated that synthetic pillows contain significantly more pet allergens than feather pillows, supporting the view that tightly woven encasements surrounding feather pillows act as a barrier for allergens... - Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UKA Simpson
North-west Lung Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK
Allergy 58:53-6. 2003..The results suggest that the Group 5 allergens of D. pteronyssinus and B. tropicalis are species-specific... - Body mass index in young children and allergic disease: gender differences in a longitudinal studyC S Murray
Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK
Clin Exp Allergy 41:78-85. 2011..The increase in allergic diseases has occurred in parallel with the obesity epidemic, suggesting a possible association... - Allergy and infection: understanding their relationshipA Custovic
Academic Division of Medicine and Surgery South, University of Manchester, North West Lung Centre, Wythenshawe Hospital, Manchester, UK
Allergy 60:10-3. 2005..Further investigation of this synergism could help to understand the mechanisms of asthma exacerbations and lead to the development of strategies for prevention... - Dietary antioxidant intake, allergic sensitization and allergic diseases in young childrenS Patel
School of Translational Medicine, University of Manchester and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
Allergy 64:1766-72. 2009..The aetiology remains unclear but is likely to be a result of changing lifestyle and/or environment. A reduction in antioxidant intake, consequent to reduced intake of fresh fruits and vegetables, has been suggested as a possible cause... - Household characteristics and mite allergen levels in Manchester,UKA Simpson
North-west Lung Centre, Wythenshawe Hospital, Manchester, UK
Clin Exp Allergy 32:1413-9. 2002..Factors such as older homes, carpets and mattresses, damp and condensation are associated with higher mite allergen. However, mite allergen levels are occasionally unpredictably very low in homes with risk factors for high levels... - Modelling air pollution for epidemiologic research--part II: predicting temporal variation through land use regressionA Molter
Centre for Occupational and Environmental Health, School of Community Based Medicine, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
Sci Total Environ 409:211-7. 2010..The advantage of this study is that it uses data from an air dispersion model, which provided concentrations for 2005 and 2010, and therefore allowed extrapolation over a longer time period...