Research Topics
| Trevor SharpSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Neuroscience. A new molecule to brighten the moodTrevor Sharp
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Science 311:45-6. 2006- Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysisLaura J Boothman
University Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK
Neuropharmacology 50:726-32. 2006..The lack of augmentation of fluoxetine might reflect the intrinsic 5-HT(2) receptor antagonist properties of this drug... - 5-HT and depression: is the glass half-full?Trevor Sharp
University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK
Curr Opin Pharmacol 11:45-51. 2011..This article highlights recent discoveries that advance our understanding of how 5-HT-evoked changes at molecular, cellular and neuropsychological levels might interact to alleviate the symptoms of clinical depression... - Important messages in the 'post': recent discoveries in 5-HT neurone feedback controlTrevor Sharp
University Department of Pharmacology, Mansfield Road, Oxford, UK
Trends Pharmacol Sci 28:629-36. 2007.... - Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methodsMihaly Hajos
Oxford University Department of Pharmacology, Mansfield Road, Oxford, OX2 6HE, UK
Eur J Neurosci 25:119-26. 2007..Collectively these data provide direct evidence that DRN neurons that exhibit stereotyped burst firing activity are 5-HT containing. The presence of multiple types of electrophysiologically distinct midbrain 5-HT neurons is discussed... - Activation of 5-HT(6) receptors facilitates attentional set shiftingKatherine E Burnham
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
Psychopharmacology (Berl) 208:13-21. 2010..Although 5-HT depletion studies do not support a role for 5-HT in attentional set shifting, the effect of 5-HT activation using specific receptor agonists has not been tested... - Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signalsKatie Ann Jennings
University Department of Pharmacology, Oxford, UK
J Neurochem 115:965-73. 2010..Overall, the findings suggest that variation in 5-HTT expression has a marked effect on frequency sensitivity which is a fundamental property of normal 5-HT transmission... - Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptorsFlorence Serres
Department of Pharmacology, University of Oxford, Oxford, UK
J Psychopharmacol 20:570-6. 2006..These data suggest that the parietal cortex plays a role in the central actions of NK1 receptor antagonists... - Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brainMarisa Le Masurier
Department of Pharmacology, Oxford University, UK
Neuropsychopharmacology 31:310-7. 2006..This minimal mixture may have use as a dopamine reducing paradigm in patient and volunteer studies... - Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brainMark A Preece
Department of Pharmacology, University of Oxford, Oxford, United Kingdom
Synapse 61:925-32. 2007..This study investigated the potential of in vivo functional magnetic resonance imaging (fMRI) methods as a noninvasive means to detect effects of tyrosine depletion on dopamine function... - Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmissionKatie A Jennings
Department of Pharmacology, Oxford University, Oxford OX1 3QT, United Kingdom
J Neurosci 26:8955-64. 2006..In toto, these findings demonstrate that associations between increased 5-HTT expression and anxiety can be modeled in mice and may be specifically mediated by decreases in 5-HT transmission... - Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanismEva Hajos-Korcsok
University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK
Pharmacol Biochem Behav 71:807-13. 2002..Although raphe stimulation may be useful to investigate interactions between 5-HT and dopamine, our data indicate that the same approach may not be feasible for 5-HT and noradrenaline... - Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision makingMark E Walton
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Eur J Neurosci 29:1678-91. 2009..Taken together, this implies that only ACC lesions, and not 6-hydroxydopamine NAc lesions as performed here, cause a bias away from investing effort for greater reward when choosing between competing options.. - A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback controlLaura J Boothman
University Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK
Neuroreport 16:891-6. 2005..These findings suggest that activated local GABA neurons may play an important role in 5-HT2 receptor-mediated feedback control of DRN 5-HT neurons... - Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatmentRosa M Tordera
University Department of Pharmacology, Oxford, UK
J Neurochem 94:875-83. 2005..These data suggest that a course of antidepressant drug or ECS treatment increases expression of VGLUT1, a key gene involved in the regulation of glutamate secretion... - Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET studyMarisa Le Masurier
University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK
Synapse 51:151-7. 2004.... - The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortexQi Pei
Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3QT, UK
Eur J Pharmacol 489:179-85. 2004.... - The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortexQi Pei
Department of Pharmacology, Oxford University, Mansfield Road, OX1 3QT, Oxford, UK
Eur J Pharmacol 495:227-33. 2004.... - Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administrationElena Castro
Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain
J Neurochem 85:1480-7. 2003..These data provide molecular evidence that co-administration of a 5-HT re-uptake inhibitor and 5-HT1A receptor antagonist increases 5-HT function at the postsynaptic level... - Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studiesElla Hirani
Imaging Research Solutions Ltd, Cyclotron Building, London W12 0NN, UK
Synapse 50:251-60. 2003.... - Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-BZoe A Hughes
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex, CM19 5AW, UK
Psychopharmacology (Berl) 192:121-33. 2007..The delay in onset and treatment resistance of subpopulations of depressed patients to conventional serotonin reuptake inhibitors has lead to new drug development strategies to produce agents with improved antidepressant efficacy... - Studies on the role of calcium in the 5-HT-stimulated release of glutamate from C6 glioma cellsRobert Meller
University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford OX2 6HE, UK
Eur J Pharmacol 445:13-9. 2002..We conclude that the 5-HT-induced efflux of glutamate from C6 glioma cells is Ca(2+)-dependent and involves, at least in part, the mobilisation of Ca(2+) from inositol (1,4,5) tris phosphate (IP(3)) sensitive intracellular stores... - Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugsNicolas Singewald
Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
Biol Psychiatry 53:275-83. 2003..Together, these data are consistent with the theory of an integrated forebrain and hindbrain neuronal system that is important for anxiety states evoked by both drug and environmental manipulations... - Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian ratsAhmet H Kaya
Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey
Brain Res 1221:93-7. 2008..These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain... - Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonismLaura Wiseman Harris
University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
Eur J Neurosci 18:1706-10. 2003.... - Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleusYasin Temel
Department of Neurosurgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
Proc Natl Acad Sci U S A 104:17087-92. 2007..More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder... - S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropiniroleMark J Millan
Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, Paris, France
J Pharmacol Exp Ther 309:936-50. 2004..Its actions are more pronounced than those of ropinirole and principally involve engagement of D(2) receptors... - In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptorsMihaly Hajos
Neurobiology, Pharmacia Corporation, 301 Henrietta Street, Kalamazoo, MI 49007, USA
Neuropharmacology 45:72-81. 2003..Some of these mPFC neurones may be part of a 5-HT1A receptor-controlled postsynaptic feedback loop to the DRN and MRN... - Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studiesArlene D Stark
Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
Psychopharmacology (Berl) 190:373-82. 2007..Aripiprazole interacts with a range of receptors, including serotonin [5-hydroxytryptamine (5-HT)] and dopamine receptors...