Research Topics
Species | Tina ShahSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk predictionTina Shah
Centre for Clinical Pharmacology, University College London, United Kingdom
Circ Cardiovasc Genet 3:436-44. 2010..Most observational studies of CRP and cardiovascular disease have been in Europeans. We evaluated the influence of ancestry on population CRP concentration to assess the implications for statin targeting in non-Europeans...- Detecting, predicting and modifying cardiovascular risk: new and developing strategiesTina Shah
Centre for Clinical Pharmacology, British Heart Foundation Laboratories at UCL, Rayne Building, 5 University Street, London, WC1E 6JJ, UK
Expert Rev Cardiovasc Ther 8:1519-21. 2010..This article focuses on some of these factors, as well as risk prediction and detection, and concludes with the current state of antiatherogenic treatment strategies... - Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
Circulation 121:52-62. 2010..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target... - Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics CollaborationAspasia Angelakopoulou
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Eur Heart J 33:393-407. 2012.... - Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstreamEric J Brunner
Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom
PLoS Med 5:e155. 2008..Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables... - Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChipPhilippa J Talmud
Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
Am J Hum Genet 85:628-42. 2009..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically... - CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysisMichael V Holmes
Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Pl, London, WC1E 6BT, United Kingdom
JAMA 306:2704-14. 2011.... - Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChipDelilah Zabaneh
University College London Genetics Institute, Department of Genetics, Environment and Evolution, London, UK
Ann Hum Genet 75:456-67. 2011..These data demonstrate that multiple common alleles with small effects make, in combination, important contributions to individual differences in vWF levels... - Blood pressure loci identified with a gene-centric arrayToby Johnson
Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Am J Hum Genet 89:688-700. 2011.... - C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart StudyJack J Mann
Centre for Cardiovascular Genetics, BHF Laboratories, Royal Free and University CollegeMedical School, London, UK
J Cardiovasc Pharmacol 55:26-9. 2010..68 mg/L higher than carriers of the C allele... - Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studiesMichael V Holmes
Centre for Clinical Pharmacology, University College London, London, United Kingdom
PLoS ONE 4:e7960. 2009..Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics)... - C-reactive protein and coronary heart disease: predictive test or therapeutic target?Aroon D Hingorani
Division of Population Sciences, Department of Epidemiology and Public Health, University College London, London, UK
Clin Chem 55:239-55. 2009..The research has encompassed observational and genetic epidemiology, basic science studies with cells and tissues, experiments with animal models and humans, and randomized trials (although not of specific CRP-lowering therapies as yet)... - Insight into the nature of the CRP-coronary event association using Mendelian randomizationJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
Int J Epidemiol 35:922-31. 2006..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded... - Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II StudyMika Kivimaki
Department of Epidemiology and Public Health, University College London, London, United Kingdom
PLoS ONE 3:e3013. 2008.... - Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohortsTina Shah
Centre for Clinical Pharmacology, University College London, London, UK
Int J Epidemiol 38:217-31. 2009..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...