Research Topics
| M L SeghierSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Predicting language lateralization from gray matterGoulven Josse
Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
J Neurosci 29:13516-23. 2009..This is the first demonstration that structural brain scans can be used to predict language lateralization on a voxel-by-voxel basis in the normal healthy brain...- Dissociating functional brain networks by decoding the between-subject variabilityMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 45:349-59. 2009.... - Reading aloud boosts connectivity through the putamenMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
Cereb Cortex 20:570-82. 2010..We conclude that the putamen plays a special role in reading but this is likely to vary with individual reading preferences and strategies... - The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with strokeAlexander P Leff
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
Brain 132:3401-10. 2009..The method applied here will be particularly useful for modelling structure-function relationships within other complex cognitive domains... - The role of functional magnetic resonance imaging in the study of brain development, injury, and recovery in the newbornMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom
Semin Perinatol 34:79-86. 2010.... - Explaining left lateralization for words in the ventral occipitotemporal cortexMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
J Neurosci 31:14745-53. 2011..Moreover, the determinants of lateralization include both visual and semantic factors depending on the subregion tested... - Lesion identification using unified segmentation-normalisation models and fuzzy clusteringMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London UK
Neuroimage 41:1253-66. 2008..From a clinical perspective, our method should help to compute the total volume of lesion or to trace precisely lesion boundaries that might be pertinent for surgical or diagnostic purposes... - Detecting subject-specific activations using fuzzy clusteringMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 36:594-605. 2007..The advantage of using FCP is that it searches all voxels systematically and can identify atypical activation patterns in a quantitative and unsupervised manner... - Inter-subject variability in the use of two different neuronal networks for reading aloud familiar wordsM L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
Neuroimage 42:1226-36. 2008..We discuss the implications of these results which may be important for understanding how reading is learnt in childhood or re-learnt following brain damage in adulthood... - Functional MRI of the newbornMohamed L Seghier
Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
Semin Fetal Neonatal Med 11:479-88. 2006..We expect a rapid expansion of this field and the establishment of fMRI as a valid clinical diagnostic tool in the newborn... - Laterality index in functional MRI: methodological issuesMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL London, UK
Magn Reson Imaging 26:594-601. 2008..Although these factors are common to a range of fMRI domains, they are discussed here in the context of fMRI of the language system... - Functional subdivisions in the left angular gyrus where the semantic system meets and diverges from the default networkMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 30:16809-17. 2010..Our findings provide a framework for reporting and interpreting AG activations with greater definition... - Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written wordsMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London WC1N 3BG, UK
Cereb Cortex 21:1519-31. 2011..These results have theoretical implications for understanding how left and right hemispheres communicate with one another during the processing of lateralized functions... - Regional and hemispheric determinants of language laterality: implications for preoperative fMRIMohamed L Seghier
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
Hum Brain Mapp 32:1602-14. 2011..We therefore highlight the importance of investigating within hemisphere regional variations in fMRI activation, prior to neuro-surgical intervention, to determine how each hemisphere and each region contributes to language processing... - The main sources of intersubject variability in neuronal activation for reading aloudFerath Kherif
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK
J Cogn Neurosci 21:654-68. 2009..We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud... - Explaining function with anatomy: language lateralization and corpus callosum sizeGoulven Josse
Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
J Neurosci 28:14132-9. 2008..We discuss the complex interhemispheric processes that might underlie this effect... - Predicting language outcome and recovery after stroke: the PLORAS systemCathy J Price
Wellcome Trust Center for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Nat Rev Neurol 6:202-10. 2010..The outputs of this system are the longitudinal language outcomes of corresponding patients in the database. This approach will provide the patient with a range of probable recovery patterns over a variety of language measures... - Multinomial inference on distributed responses in SPMJ R Chumbley
The Wellcome Trust Centre for Neuroimaging, UCL, UK
Neuroimage 53:161-70. 2010..We illustrate the method by characterising the anatomy of language at different scales of functional segregation... - Lesion sites that predict the ability to gesture how an object is usedC J Price
Wellcome Trust Centre for Neuro imaging, Institute of Neurology, University College London, UK
Arch Ital Biol 148:243-58. 2010..Our methods provide a framework for future studies aiming to predict the consequences of brain damage... - Brain activation using triggered event-related fMRIIvan Zimine
Department of Radiology, Geneva University Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Neuroimage 18:410-5. 2003..We conclude that this can be a useful technique for studying brain activation associated with irregularly appearing stimuli... - WSPM: wavelet-based statistical parametric mappingDimitri van de Ville
Biomedical Imaging Group, Ecole Polytechnique Federale de Lausanne EPFL, and Department of Radiology and Medical Informatics, University Hospital Geneva, Switzerland
Neuroimage 37:1205-17. 2007..The full approach is available as a toolbox, named WSPM, for the SPM2 software; it takes advantage of multiple options and features of SPM such as the general linear model... - Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language taskMohamed L Seghier
Department of Radiology, Geneva University Hospitals, Geneva, Switzerland
Hum Brain Mapp 29:461-77. 2008.... - Rhyme processing in the brain: an ERP mapping studyAsaid Khateb
Laboratory of Experimental Neuropsychology, Department of Neurology, University Hospital, Geneva, Switzerland
Int J Psychophysiol 63:240-50. 2007..Our results suggest that, similar to the N400 component that is also induced by mismatch contexts, the N450 might rely on temporal generators... - Neural systems for orienting attention to the location of threat signals: an event-related fMRI studyGilles Pourtois
Neurology and Imaging of Cognition, Clinic of Neurology, University Hospital and Department of Neurosciences, University Medical Center, Switzerland
Neuroimage 31:920-33. 2006..Neural mechanisms responsible for orienting attention towards emotional vs. non-emotional stimuli are thus partly shared in parietal and visual areas, but also partly distinct... - Portraits or people? Distinct representations of face identity in the human visual cortexGilles Pourtois
Neurology and Imaging of Cognition, Clinic of Neurology and Department of Neurosciences, University of Geneva, Switzerland
J Cogn Neurosci 17:1043-57. 2005..This pattern provides new insights into the nature of face representation in the human visual system... - Variability of fMRI activation during a phonological and semantic language task in healthy subjectsMohamed L Seghier
Department of Radiology, Geneva University Hospital, CH-1211 Geneva, Switzerland
Hum Brain Mapp 23:140-55. 2004.... - FMRI evidence for activation of multiple cortical regions in the primary auditory cortex of deaf subjects users of multichannel cochlear implantsMohamed L Seghier
Department of Radiology, University Hospital of Geneva, Micheli du Crest 24, 1211 Geneva, Switzerland
Cereb Cortex 15:40-8. 2005..These arguments, obtained without interference with unwanted scanner noise, plead in favor of a functional subdivision of the primary auditory cortex into multiple cortical regions in cochlear implant users... - Transient crossed aphasia evidenced by functional brain imageryAsaid Khateb
Neuropsychology Unit, Department of Neurology, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Neuroreport 15:785-90. 2004..In the light of previous studies reporting much frequent bilateral than exclusive right hemisphere representations, we hypothesise that some crossed aphasia cases could occur in subjects with bilateral language representation... - Tactile awareness and limb position in neglect: functional magnetic resonance imagingNathalie Valenza
Department of Neurology and Neurosciences, University of Geneva, Switzerland
Ann Neurol 55:139-43. 2004..Activity in bilateral middle frontal gyri also was modulated by limb position and may contribute to integrate sensory inputs into a supramodal, egocentric representation of space... - Anatomical variability of the lateral frontal lobe surface: implication for intersubject variability in language neuroimagingHeike Juch
Department of Morphology, Division of Anatomy, Medical School, University of Geneva, 1, Geneva, CH-1211, Switzerland
Neuroimage 24:504-14. 2005..We therefore suggest to express functional activation in relation to landmarks obtained from individual anatomy. This approach may contribute to a better analysis of the differences between individuals... - The voices of wrath: brain responses to angry prosody in meaningless speechDidier Grandjean
Geneva Emotion Research Group, Department of Psychology, University of Geneva, Bd du Pont d Arve 40, CH 1205 Geneva, Switzerland
Nat Neurosci 8:145-6. 2005..Attention and emotion seem to have separate effects on stimulus processing, reflecting a fundamental principle of human brain organization shared by voice and face perception... - View-independent coding of face identity in frontal and temporal cortices is modulated by familiarity: an event-related fMRI studyGilles Pourtois
Department of Neurosciences, Neurology and Imaging of Cognition, Clinic of Neurology, University Hospital, University Medical Center, Switzerland
Neuroimage 24:1214-24. 2005.... - Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke painMohamed L Seghier
Department of Radiology, University of Hospital of Geneva, Switzerland
J Pain 6:208-12. 2005..Our investigations show, for CPSP pathogenesis, the role of damage of lateral nociceptive thalamoparietal fibers together with the release of activity of anterior cingulate and posterior parietal regions... - Emotion and attention interactions in social cognition: brain regions involved in processing anger prosodyDavid Sander
Geneva Emotion Research Group, Department of Psychology, University of Geneva, Switzerland
Neuroimage 28:848-58. 2005.... - Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case reportMohamed L Seghier
Department of Radiology, Geneva University Hospitals, Micheli du Crest 24, 1211 Geneva, Switzerland
BMC Neurol 5:17. 2005..Thus, new non-invasive methods capable of early functional diagnosis are needed in young infants... - The fusiform face area is tuned for curvilinear patterns with more high-contrasted elements in the upper partRoberto Caldara
Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, 58 Hillhead Street, Glasgow, G12 8QB, UK
Neuroimage 31:313-9. 2006..These findings provide direct evidence that the FFA is tuned for geometrical properties fitting best with the structure of faces, a computational mechanism that might drive the automatic detection of faces in the visual world... - Language control and lexical competition in bilinguals: an event-related FMRI studyJubin Abutalebi
Centre for Cognitive Neurosciences, Vita Salute San Raffaele University and Scientific Institute San Raffaele, 20132 Milan, Italy
Cereb Cortex 18:1496-505. 2008....