Peter M Rothwell

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
  2. ncbi Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
  3. ncbi Five years of Trials
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College Annexe, Linton Road, Oxford OX2 6UD, UK
    Trials 12:248. 2011
  4. ncbi Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
  5. ncbi Sex difference in the effect of time from symptoms to surgery on benefit from carotid endarterectomy for transient ischemic attack and nondisabling stroke
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford, UK OX2 6HE
    Stroke 35:2855-61. 2004
  6. ncbi Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis
    Peter M Rothwell
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:116-25. 2007
  7. ncbi Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, UK
    Stroke 35:2300-5. 2004
  8. ncbi Carotid endarterectomy for asymptomatic carotid stenosis: asymptomatic carotid surgery trial
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE
    Stroke 35:2425-7. 2004
  9. ncbi Lessons from MATCH for future randomised trials in secondary prevention of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 364:305-7. 2004
  10. ncbi Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 363:1925-33. 2004

Detail Information

Publications144 found, 100 shown here

  1. ncbi Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
    ..We established the frequency of distant metastasis in patients who developed cancer during trials of daily aspirin versus control...
  2. ncbi Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
    ..We studied cancer deaths in all trials of daily aspirin versus control and the time course of effects of low-dose aspirin on cancer incidence and other outcomes in trials in primary prevention...
  3. ncbi Five years of Trials
    Douglas G Altman
    Centre for Statistics in Medicine, Wolfson College Annexe, Linton Road, Oxford OX2 6UD, UK
    Trials 12:248. 2011
    ..These include the publication of raw data, extended versions of previously published trial-related articles, descriptions of 'lessons learned', negative results, and educational articles regarding ethics and reporting bias...
  4. ncbi Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
    ..A standardized and transparent approach to HTE assessment and reporting could substantially improve clinical trial utility and interpretability...
  5. ncbi Sex difference in the effect of time from symptoms to surgery on benefit from carotid endarterectomy for transient ischemic attack and nondisabling stroke
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford, UK OX2 6HE
    Stroke 35:2855-61. 2004
    ..To determine the effect of delay to CEA on operative risk and benefit, we pooled data from the North American Symptomatic Carotid Endarterectomy Trial and the European Carotid Surgery Trial...
  6. ncbi Current status of carotid endarterectomy and stenting for symptomatic carotid stenosis
    Peter M Rothwell
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:116-25. 2007
    ....
  7. ncbi Fibrinogen concentration and risk of ischemic stroke and acute coronary events in 5113 patients with transient ischemic attack and minor ischemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, UK
    Stroke 35:2300-5. 2004
    ..Fibrinogen is an independent risk factor for coronary events in population-based studies and in patients with coronary heart disease, but there is uncertainty about prediction of stroke, particularly in secondary prevention...
  8. ncbi Carotid endarterectomy for asymptomatic carotid stenosis: asymptomatic carotid surgery trial
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE
    Stroke 35:2425-7. 2004
  9. ncbi Lessons from MATCH for future randomised trials in secondary prevention of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 364:305-7. 2004
  10. ncbi Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 363:1925-33. 2004
    ..We aimed to obtain these data...
  11. ncbi Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 363:915-24. 2004
    ..Benefit depends on the degree of stenosis, and we aimed to see whether it might also depend on other clinical and angiographic characteristics, and on the timing of surgery...
  12. ncbi Prognostic models
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Pract Neurol 8:242-53. 2008
    ..This article considers how such models are best derived, and how their reliability should be assessed, drawing on examples from various different neurological disorders...
  13. ncbi Medical and surgical management of symptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Int J Stroke 1:140-9. 2006
    ..Individual risk modelling has been shown to be useful in selecting patients with the most to gain from endarterectomy for symptomatic stenosis, although timely surgery and optimal medical treatment are of equal importance...
  14. ncbi Effective stroke prevention in patients with symptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 17:89-104. 2004
    ..Such an approach will also be useful in targeting angioplasty and stenting in patients in whom endarterectomy is not possible...
  15. ncbi Endarterectomy for symptomatic and asymptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    Neurol Clin 26:1079-97, x. 2008
    ..Long-term benefit from endarterectomy for asymptomatic carotid stenosis is limited, and further research is required to identify individuals with asymptomatic stenosis who have the most to gain from surgery...
  16. ncbi Relationship between blood pressure and stroke risk in patients with symptomatic carotid occlusive disease
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE UK
    Stroke 34:2583-90. 2003
    ..Therefore, we studied the effect of carotid artery disease on the relationship between blood pressure and stroke risk in patients with recent TIA or stroke...
  17. ncbi Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 370:1432-42. 2007
    ..Our aim was to determine the effect of more rapid treatment after TIA and minor stroke in patients who are not admitted direct to hospital...
  18. ncbi Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:176-86. 2005
    ..Formal rules for the planning, analysis, and reporting of subgroup analyses are proposed...
  19. ncbi Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 366:1773-83. 2005
    ..In the Oxford Vascular Study, we determined the comparative epidemiology of different acute vascular syndromes, their current burdens, and the potential effect of the ageing population on future rates...
  20. ncbi Prevention of stroke in patients with diabetes mellitus and the metabolic syndrome
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 20:24-34. 2005
    ..Optimization of strategies to prevent vascular complications must be a priority, given the rapid rises in the incidence and prevalence of type 2 diabetes and the metabolic syndrome in most populations across the globe...
  21. ncbi Recent advances in management of transient ischaemic attacks and minor ischaemic strokes
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet Neurol 5:323-31. 2006
    ....
  22. ncbi Risk modeling to identify patients with symptomatic carotid stenosis most at risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    Neurol Res 27:S18-28. 2005
    ..In order to take into account all of the relevant factors, a risk prediction model is considered...
  23. ncbi Symptomatic and asymptomatic carotid stenosis: how, when, and who to treat?
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, United Kingdom
    Curr Atheroscler Rep 8:290-7. 2006
    ..Further research is required in order to determine the role of carotid stenting and to identify those individuals with asymptomatic stenosis who have the most to gain from intervention...
  24. ncbi Funding for practice-oriented clinical research
    Peter M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 368:262-6. 2006
  25. ncbi Does transient ischemic attack deserve emergency care?
    Peter M Rothwell
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Nat Clin Pract Neurol 2:174-5. 2006
  26. ncbi A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack
    P M Rothwell
    Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Lancet 366:29-36. 2005
    ..Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke...
  27. ncbi Clinical trials are too often founded on poor quality pre-clinical research
    P M Rothwell
    Stroke Prevention Research Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Neurol 252:1115. 2005
  28. ncbi Observational comparisons of different clinical services
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford OX2 6HE, UK
    Lancet 369:254-5. 2007
  29. ncbi Timing of TIAs preceding stroke: time window for prevention is very short
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Neurology 64:817-20. 2005
    ..Patients with TIA are at increased risk of ischemic stroke and require preventive treatment. However, clinical guidelines differ on how urgently patients should be assessed...
  30. ncbi Treating individuals 3: from subgroups to individuals: general principles and the example of carotid endarterectomy
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 365:256-65. 2005
    ....
  31. ncbi External validity of randomised controlled trials: "to whom do the results of this trial apply?"
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 365:82-93. 2005
    ..This review discusses those determinants, presents a checklist for clinicians, and makes recommendations for greater consideration of external validity in the design and reporting of RCTs...
  32. ncbi Transient ischemic attacks: stratifying risk
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Stroke 37:320-2. 2006
  33. ncbi Is intravenous recombinant plasminogen activator effective up to 4.5 h after onset of ischemic stroke?
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Nat Clin Pract Cardiovasc Med 6:164-5. 2009
    ..Ongoing trials aim to determine whether eligibility for thrombolysis can be extended in other ways, such as to patients aged over 80 years, patients with severe stroke, or patients with lacunar stroke...
  34. ncbi Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:31-41. 2011
    ..We studied deaths due to cancer during and after randomised trials of daily aspirin versus control done originally for prevention of vascular events...
  35. ncbi Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 9:469-80. 2010
    ..We aimed to investigate whether the effects of these drugs on variability in blood pressure might explain these disparities in effect on stroke risk...
  36. ncbi Does blood pressure variability modulate cardiovascular risk?
    Peter M Rothwell
    University Department of Clinical Neurology, John Radcliffe Hospital, Level 6, West Wing, Headington, Oxford OX3 9DU, UK
    Curr Hypertens Rep 13:177-86. 2011
    ....
  37. ncbi Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:1681-92. 2011
    ..We review the main medical treatments that should be considered for most patients with transient ischaemic attack or ischaemic stroke in the acute phase and the long term, and draw attention to recent developments...
  38. ncbi Evidence of a chronic systemic cause of instability of atherosclerotic plaques
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 355:19-24. 2000
    ....
  39. ncbi Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:615-21. 2000
    ..We sought to determine the interrelation between plaque surface morphology, degree of carotid stenosis, and the risk of ipsilateral ischemic stroke...
  40. ncbi Low risk of ischemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis: cerebral protection due to low poststenotic flow? On behalf of the European Carotid Surgery Trialists' Collaborative
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:622-30. 2000
    ....
  41. ncbi Analysis of agreement between measurements of continuous variables: general principles and lessons from studies of imaging of carotid stenosis
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Neurol 247:825-34. 2000
    ..The advantages and disadvantages of each of the methods are discussed in a non-technical and non-mathematical manner, and illustrated using data from a study of measurement of carotid stenosis by two observers on 1001 carotid angiograms...
  42. ncbi Carotid artery disease and the risk of ischaemic stroke and coronary vascular events
    P M Rothwell
    Oxford Stroke Prevention Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 10:21-33. 2000
    ..Future studies should also determine the relationship between the various measures of carotid wall disease and the risk of stroke for the different subtypes of ischaemic stroke...
  43. ncbi Critical appraisal of the design and reporting of studies of imaging and measurement of carotid stenosis
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 31:1444-50. 2000
    ..We aimed to assess the design and methods of a random sample of published studies of imaging and measurement of carotid stenosis using 9 simple criteria...
  44. ncbi Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 361:107-16. 2003
    ..To accurately assess the overall effect of surgery, and to increase power for secondary analyses, we pooled trial data and reassessed carotid angiograms...
  45. ncbi Reanalysis of the final results of the European Carotid Surgery Trial
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 34:514-23. 2003
    ..This disparity has led to inconsistent clinical recommendations but may have been due to differences between the trials in the methods of measurement of carotid stenosis and definitions of outcome events...
  46. ncbi Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 376:1741-50. 2010
    ..The long-term effectiveness of lower doses (75-300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour...
  47. ncbi Cerebrovascular complications of therapeutic neck manipulation. The need for reliable data on risks and risk factors
    P M Rothwell
    Stroke Prevention Research Unit, Departrment of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Neurol 249:1105-6. 2002
  48. ncbi Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:895-905. 2010
    ..We aimed to reliably establish the prognostic significance of visit-to-visit variability in blood pressure, maximum blood pressure reached, untreated episodic hypertension, and residual variability in treated patients...
  49. ncbi Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:938-48. 2010
    ....
  50. ncbi For severe carotid stenosis found on ultrasound, further arterial evaluation prior to carotid endarterectomy is unnecessary: the argument against
    Peter M Rothwell
    Radcliffe Infirmary, Stroke Prevention Research Unit, Department of Clinical Neurology, Oxford OX2 6HE, UK
    Stroke 34:1817-9; discussion 1819. 2003
  51. ncbi Reproducibility of peer review in clinical neuroscience. Is agreement between reviewers any greater than would be expected by chance alone?
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Brain 123:1964-9. 2000
    ....
  52. ncbi Clinical and angiographic predictors of stroke and death from carotid endarterectomy: systematic review
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 315:1571-7. 1997
    ..To identify risk factors for operative stroke and death from carotid endarterectomy...
  53. ncbi Incidence, risk factors and prognosis of stroke and TIA: the need for high-quality, large-scale epidemiological studies and meta-analyses
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Cerebrovasc Dis 16:2-10. 2003
    ..In many cases, this will require meta-analysis of detailed individual patient data from multiple independent studies...
  54. ncbi High incidence and prevalence of multiple sclerosis in south east Scotland: evidence of a genetic predisposition
    P M Rothwell
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland
    J Neurol Neurosurg Psychiatry 64:730-5. 1998
    ..To determine the incidence and prevalence of multiple sclerosis in the Lothian and Border Health Board Regions of south east Scotland...
  55. ncbi Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists' Collaborative Group
    P M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 353:2105-10. 1999
    ..We investigated whether the efficacy of endarterectomy would be improved if patients with a high risk of stroke on medical treatment and a low risk of operative stroke or death could be identified...
  56. ncbi Poor performance of current prognostic scores for early risk of recurrence after minor stroke
    Arvind Chandratheva
    Department of Clinical Neurology, University of Oxford, on behalf of the Oxford Vascular Study, Stroke Prevention Research Unit, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 42:632-7. 2011
    ..The early risk of recurrence after minor stroke is as high but the only validated prognostic scores for use in minor stroke predict long-term risk of recurrence: the Essen Stroke Risk Score and the Stroke Prognosis Instrument II...
  57. ncbi Potential consequences for recruitment, power, and external validity of requirements for additional risk factors for eligibility in randomized controlled trials in secondary prevention of stroke
    Sally C Howard
    Department of Clinical Neurology, University of Oxford, United Kingdom
    Stroke 37:209-15. 2006
    ....
  58. ncbi Population-based study of determinants of initial secondary care costs of acute stroke in the United Kingdom
    Ramon Luengo-Fernandez
    Health Economics Research Centre, University of Oxford, Oxford, UK
    Stroke 37:2579-87. 2006
    ..CONCLUSIONS: Several patient and event-related characteristics explained the wide range of initial secondary care costs of acute stroke, but stroke severity was by far the most important independent predictor...
  59. ncbi Family history of stroke does not predict risk of stroke after transient ischemic attack
    Enrico Flossmann
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Stroke 37:544-6. 2006
    ..76) or risk of MI during follow-up. There was no bias attributable to any relationship between FHxstroke and risk factor control or medication. CONCLUSIONS: Family history of stroke does not predict risk of ischemic stroke after TIA...
  60. ncbi Family history of stroke in patients with transient ischemic attack in relation to hypertension and other intermediate phenotypes
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 36:830-5. 2005
    ..This should be taken into account in studies of the genetics of ischemic stroke...
  61. ncbi Critical cap thickness and rupture in symptomatic carotid plaques: the oxford plaque study
    Jessica N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Stroke 39:1722-9. 2008
    ..While a cap thickness <65 microm is the accepted definition of rupture-prone plaque in the coronary circulation, the threshold value for carotid plaques is unknown...
  62. ncbi Substantial observer variability in the differentiation between primary intracerebral hemorrhage and hemorrhagic transformation of infarction on CT brain imaging
    Caroline E Lovelock
    Stroke Prevention Research Unit, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 40:3763-7. 2009
    ..Interobserver reliability in distinguishing hemorrhagic transformation of infarction from intracerebral hemorrhage may depend on delays to CT but has not been reported previously despite the clinical importance of this distinction...
  63. ncbi Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests
    Paul Harrison
    Oxford Haemophilia and Thrombosis Centre, Oxford, UK
    Platelets 19:119-24. 2008
    ..Lack of consistency over time in identification of apparently non-responsiveness individuals is likely to substantially undermine any ability of these tests to predict risk of recurrent vascular events...
  64. ncbi Relative familial clustering of cerebral versus coronary ischemic events
    Amitava Banerjee
    Stroke Prevention Research Unit, University of Oxford, United Kingdom
    Circ Cardiovasc Genet 4:390-6. 2011
    ..Differences in heritability of transient ischemic attack and ischemic stroke versus acute coronary syndromes (ACS) may inform risk prediction, genetic studies, and understanding of disease mechanisms...
  65. ncbi The need for emergency treatment of transient ischemic attack and minor stroke
    Matthew F Giles
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK
    Expert Rev Neurother 5:203-10. 2005
    ....
  66. ncbi Asymptomatic carotid stenosis: what to do
    Jessica N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, UK
    Curr Opin Neurol 20:58-64. 2007
    ..Patients with asymptomatic carotid stenosis are at increased vascular risk but optimal treatment is controversial. We reviewed the current evidence for medical and surgical intervention in these patients...
  67. ncbi Clinical and radiographic risk factors for operative stroke and death in the European carotid surgery trial
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford, UK
    Eur J Vasc Endovasc Surg 23:108-16. 2002
    ..Several baseline patient characteristics predict surgical risk and it may be possible to use these characteristics to aid patient selection and surgical audit...
  68. ncbi Differences in vascular risk factors between etiological subtypes of ischemic stroke: importance of population-based studies
    U G R Schulz
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford OX2 6HE UK
    Stroke 34:2050-9. 2003
    ..Meta-analysis of population-based studies suggests that vascular risk factors differ between stroke subtypes...
  69. ncbi Reliability of clinical diagnosis of the symptomatic vascular territory in patients with recent transient ischemic attack or minor stroke
    Enrico Flossmann
    FRCP, Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, The John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Stroke 39:2457-60. 2008
    ..However, there are few published data on the accuracy of clinical assessment of the vascular territory...
  70. ncbi ABCD2 score predicts severity rather than risk of early recurrent events after transient ischemic attack
    Arvind Chandratheva
    Stroke Prevention Research Unit, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, England
    Stroke 41:851-6. 2010
    ..Do patients with high scores also have more severe early recurrent strokes, perhaps further justifying hospital admission? Do patients with low scores have a low early risk of recurrent TIA as well as recurrent stroke?..
  71. ncbi Medium-term variability of blood pressure and potential underdiagnosis of hypertension in patients with previous transient ischemic attack or minor stroke
    Robert L Cuffe
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, England
    Stroke 37:2776-83. 2006
    ....
  72. ncbi Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies
    J K Lovett
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Neurology 62:569-73. 2004
    ..CONCLUSIONS: The risk of early recurrent stroke is highest in patients with LAA. This supports the need for urgent carotid imaging and prompt endarterectomy...
  73. ncbi Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke
    E J Cunningham
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 33:2658-63. 2002
    ..This is the standard against which alternative treatments should be judged. Several risk factors may be useful in identifying patients at particularly high risk of late postoperative stroke...
  74. ncbi Variation in surgical and anaesthetic technique and associations with operative risk in the European carotid surgery trial: implications for trials of ancillary techniques
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford, UK
    Eur J Vasc Endovasc Surg 23:117-26. 2002
    ....
  75. ncbi Very early risk of stroke after a first transient ischemic attack
    J K Lovett
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE UK
    Stroke 34:e138-40. 2003
    ..Public education about the symptoms of TIA is needed so that medical attention is sought more urgently and stroke prevention strategies are implemented sooner...
  76. ncbi Effect of nonoptimal imaging on the relationship between the measured degree of symptomatic carotid stenosis and risk of ischemic stroke
    R L Cuffe
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 37:1785-91. 2006
    ..CONCLUSIONS: The dependence of the prognostic value of CAA on the type of angiography and the number of views of the stenosis obtained has implications for the future development and validation of noninvasive methods of carotid imaging...
  77. ncbi Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke
    J F Fairhead
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Neurology 65:371-5. 2005
    ....
  78. ncbi The SCAN rule: a clinical rule to reduce CT misdiagnosis of intracerebral haemorrhage in minor stroke
    C E Lovelock
    University Department of Clinical Neurosciences, Stroke Prevention Research Unit, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:271-5. 2010
    ..A clinical rule is needed to identify patients who are likely to have intracerebral haemorrhage (ICH) and require urgent brain imaging and patients who can safely start antiplatelet agents before scanning...
  79. ncbi A systematic review of the associations between age and sex and the operative risks of carotid endarterectomy
    R Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 20:69-77. 2005
    ..Operative risk of stroke is increased in women and operative mortality is increased in patients aged > or =75 years...
  80. ncbi Long term risks of stroke, myocardial infarction, and vascular death in "low risk" patients with a non-recent transient ischaemic attack
    T G Clark
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 74:577-80. 2003
    ..It is important therefore that preventive treatments are continued in the long term, even in apparently "low risk" patients who have already survived free of stroke for several years...
  81. ncbi Screening for aspirin responsiveness after transient ischemic attack and stroke: comparison of 2 point-of-care platelet function tests with optical aggregometry
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, UK
    Stroke 36:1001-5. 2005
    ..Aspirin nonresponsiveness is therefore highly test-specific and large prospective studies will be required to determine the prognostic value of each of the separate tests...
  82. ncbi Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study
    C E Lovelock
    Stroke Prevention Research Unit, Department of Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 6:487-93. 2007
    ..Trends in the older population might differ, since cause varies with age. Our aim was to investigate changes in the population-based incidence of intracerebral haemorrhage according to age and likely aetiology...
  83. ncbi Direct assessment of completeness of ascertainment in a stroke incidence study
    A J Coull
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK
    Stroke 35:2041-5. 2004
    ..However, direct assessment of ascertainment suggests that the supplementary methods used in recent studies can lead to near-complete ascertainment...
  84. ncbi Presence of acute ischaemic lesions on diffusion-weighted imaging is associated with clinical predictors of early risk of stroke after transient ischaemic attack
    J N Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 24:86-90. 2007
    ....
  85. ncbi Regression dilution of systolic and diastolic blood pressure in patients with established cerebrovascular disease
    S C Howard
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    J Clin Epidemiol 56:1084-91. 2003
    ..CONCLUSION: RDRs from population-based studies cannot necessarily be applied to cohorts with established vascular disease...
  86. ncbi Vessel wall contrast enhancement: a diagnostic sign of cerebral vasculitis
    Wilhelm Kuker
    Department of Neuroradiology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Cerebrovasc Dis 26:23-9. 2008
    ..The purpose of this study was to establish the value of contrast-enhanced MRI, proven to be sensitive to extradural arteritis, for the identification of intracranial vessel wall inflammation...
  87. ncbi Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores
    Matthew F Giles
    Stroke Prevention Research Unit, NIHR Biomedical Research Centre, Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 41:667-73. 2010
    ..Independent validations have reported conflicting results. We therefore systematically reviewed published and unpublished data to determine predictive value and generalizability to different clinical settings and users...
  88. ncbi Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis
    Sarah T Pendlebury
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 8:1006-18. 2009
    ..We undertook this systematic review to assess the heterogeneity in the reported rates and to identify risk factors for pre-stroke and post-stroke dementia...
  89. ncbi Transient ischaemic attack: clinical relevance, risk prediction and urgency of secondary prevention
    Matthew F Giles
    Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    Curr Opin Neurol 22:46-53. 2009
    ..We have reviewed recent evidence on the burden of TIA and prediction and prevention of stroke in the acute phase...
  90. ncbi Mapping the modified Rankin scale (mRS) measurement into the generic EuroQol (EQ-5D) health outcome
    Oliver Rivero-Arias
    Health Economics Research Centre, Department of Public Health, University of Oxford, UK
    Med Decis Making 30:341-54. 2010
    ..This article constructs an algorithm to translate the modified Rankin scale (mRS) into EQ-5D utility values...
  91. ncbi Influence of general practice opening hours on delay in seeking medical attention after transient ischaemic attack (TIA) and minor stroke: prospective population based study
    Daniel S Lasserson
    Department of Primary Health Care, University of Oxford, Headington, Oxford OX3 7LF
    BMJ 337:a1569. 2008
    ..To assess the influence of general practice opening hours on healthcare seeking behaviour after transient ischaemic attack (TIA) and minor stroke and feasibility of clinical assessment within 24 hours of symptom onset...
  92. ncbi Site of carotid plaque ulceration in relation to direction of blood flow: an angiographic and pathological study
    Joanna K Lovett
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Cerebrovasc Dis 16:369-75. 2003
    ..1, 95% CI = 2.8-13.6, p < 0.001). CONCLUSIONS: Ulceration of carotid plaques, visible on angiography or on pathological examination, is seen most often in the proximal (upstream) part where shear stress is highest...
  93. ncbi Normal cortical energy metabolism in migrainous stroke: A 31P-MR spectroscopy study
    Ursula G Schulz
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford OX2 9DU, UK
    Stroke 40:3740-4. 2009
    ..We used (31)P-MRS to determine whether migrainous stroke shows similar interictal abnormalities in cortical energy metabolism as severe, prolonged aura...
  94. ncbi Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in selective shunting)
    Richard Bond
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 34:824-5. 2003
  95. ncbi Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis
    Matthew F Giles
    Stroke Prevention Research Unit, Oxford University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet Neurol 6:1063-72. 2007
    ..However, reliable estimation of this risk is necessary for planning effective service provision, clinical trials, and public education. We therefore did a systematic review of all studies of stroke risk early after TIA...
  96. ncbi Systematic review of associations between the presence of acute ischemic lesions on diffusion-weighted imaging and clinical predictors of early stroke risk after transient ischemic attack
    Jessica N E Redgrave
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Stroke 38:1482-8. 2007
    ....
  97. ncbi Prediction and prevention of stroke after transient ischemic attack in the short and long term
    Matthew F Giles
    University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Expert Rev Neurother 6:381-95. 2006
    ..Recent data on the long-term (10 years and beyond) vascular risk after TIA demonstrate ongoing mortality from both cerebrovascular and cardiovascular causes, highlighting the need for continued secondary prevention...
  98. ncbi Blood pressure variability and risk of new-onset atrial fibrillation: a systematic review of randomized trials of antihypertensive drugs
    Alastair J S Webb
    Stroke Prevention Research Unit, Department of Clinical Neurology, John Radcliffe Hospital, Oxford OX39DU, UK
    Stroke 41:2091-3. 2010
    ..Increased visit-to-visit variability in blood pressure (BP) is a powerful risk factor for stroke, but the mechanism is uncertain. We hypothesized that BP variability might affect the risk of new atrial fibrillation (AF)...
  99. ncbi Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients
    Matthew F Giles
    Stroke Prevention Research Unit M F G, P M R, National Institute for Health Research Biomedical Research Centre, Oxford, UK
    Stroke 41:1907-13. 2010
    ..We therefore performed an international, multicenter collaborative study of the prognostic performance of the ABCD(2) score and brain infarction on imaging to determine the optimal weighting of infarction in the score (ABCD(2)I)...
  100. ncbi Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies
    Caroline E Lovelock
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU
    Stroke 41:1222-8. 2010
    ..Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic attack (TIA)...
  101. ncbi Costs of stroke using patient-level data: a critical review of the literature
    Ramon Luengo-Fernandez
    Department of Public Health, Health Economics Research Centre, University of Oxford, Oxford, USA
    Stroke 40:e18-23. 2009
    ..This study reports the results from a literature review of the costs of cerebrovascular diseases, and assesses the quality of the published evidence against a set of defined criteria...