Research Topics
Species | J H RobinsonSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic miceAlexei von Delwig
Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
Arthritis Res Ther 8:R93. 2006....- Colony variability under the spotlight in animal models of arthritisJohn H Robinson
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Arthritis Res Ther 11:110. 2009.... - H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar TyphimuriumS Ugrinovic
Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
Infect Immun 73:8002-8. 2005..It also expands the range of pathogens that induce H2-M3-restricted CD8 T cells to include an example of gram-negative bacteria... - Diversity in MHC class II antigen presentationJohn H Robinson
Department of Microbiology and Immunology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Immunology 105:252-62. 2002..This diversity may have profound consequences for the induction of immunity to infection and tumours, as well as autoimmunity and tolerance... - Processing of viable Salmonella typhimurium for presentation of a CD4 T cell epitope from the Salmonella invasion protein C (SipC)Julie A Musson
Department of Microbiology and Immunology, The Medical School, University of Newcastle upon Tyne, GB
Eur J Immunol 32:2664-71. 2002..However, we demonstrate that a CD4 T cell response to S. typhimurium-secreted proteins may be induced by an alternative pathway capable of antigen presentation in conditions similar to those in the compartments where Salmonella localize... - The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse modelAlexei von Delwig
Musculoskeletal Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Arthritis Rheum 54:482-91. 2006..To address this possibility, we studied the intracellular processing of CII for presentation of the arthritogenic glycosylated epitope CII(259-273) to CD4 T cells in macrophages from HLA-DR1-transgenic mice... - Differential processing of CD4 T-cell epitopes from the protective antigen of Bacillus anthracisJulie A Musson
Musculoskeletal Research Group, Clinical Medical Sciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
J Biol Chem 278:52425-31. 2003..Rapidly presented epitopes seemed to require only limited proteolysis at earlier stages of endocytosis, whereas the majority of epitopes required more extensive processing by neutral proteinases followed by lysosomal enzymes... - Localization of peptide/MHC class II complexes in macrophages following antigen processing of viable Streptococcus pyogenesAlexei von Delwig
School of Clinical Medical Sciences (Rheumatology, University of Newcastle upon Tyne, Newcastle upon Tyne, GB
Eur J Immunol 33:2353-60. 2003..Both species of peptide/MHC complexes localized to endocytic compartments, indicating a role for endosomes in presentation of antigens from phagocytosed bacteria... - TGF-beta1 and IFN-gamma cross-regulate antigen presentation to CD4 T cells by macrophagesAlexei A Delvig
Department of Rheumatology, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
J Leukoc Biol 72:163-6. 2002.... - Sequential proteolytic processing of the capsular Caf1 antigen of Yersinia pestis for major histocompatibility complex class II-restricted presentation to T lymphocytesJulie A Musson
Musculoskeletal Research Group, Institute of Cellular Medicine, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
J Biol Chem 281:26129-35. 2006.... - The role of calcium homeostasis and flux during bacterial antigen processing in murine macrophagesA A Delvig
Department of Immunology, The Medical School, Newcastle University, Newcastle upon Tyne, GB
Eur J Immunol 29:2414-9. 1999..The data suggest that alternative antigen processing pathways have different requirements for intracellular calcium homeostasis... - Distribution of productive antigen-processing activity for MHC class II presentation in macrophagesA von Delwig
Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
Scand J Immunol 62:243-50. 2005..The data suggest that endosomal compartments expressing Rab5 guanosine triphosphatase can productively process protein antigens for presentation by mature MHC class II molecules... - Mechanisms of major histocompatibility complex class II-restricted processing and presentation of the V antigen of Yersinia pestisHo-Ki Shim
Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Immunology 119:385-92. 2006..In the case of V antigen, adjuvants designed to target it to lysosomes are likely to induce optimal responses to multiple protective T-cell epitopes... - Regulation of peptide presentation by major histocompatibility complex class II molecules at the surface of macrophagesAlexei von Delwig
Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, GB
Eur J Immunol 33:3359-66. 2003..The generation of inhibitory natural peptide ligands is a new mechanism of immunoregulation which could operate during the induction of T cell responses in a variety of situations... - The route of bacterial uptake by macrophages influences the repertoire of epitopes presented to CD4 T cellsAlexei von Delwig
Department of Rheumatology, University of Newcastle upon Tyne, Newcastle upon Tyne, GB
Eur J Immunol 32:3714-9. 2002..The data suggest that distinct epitopes of a protein associated with viable bacteria may be presented optimally following different uptake mechanisms in the same antigen-presenting cells... - T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic miceAlexei von Delwig
Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Ann Rheum Dis 66:599-604. 2007.... - Major histocompatibility class II molecules prevent destructive processing of exogenous peptides at the cell surface of macrophages for presentation to CD4 T cellsAlexei von Delwig
Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Immunology 114:194-203. 2005.... - T-Cell epitope mapping the PorB protein of serogroup B Neisseria meningitidis in B10 congenic strains of miceA A Delvig
The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
Clin Immunol Immunopathol 85:134-42. 1997..g., 226-261), could have important implications for the development of meningococcal vaccines... - Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: role of gamma interferon and macrophage activationP Mastroeni
School of Microbiological, Immunological and Virological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
Infect Immun 66:4767-76. 1998..Administration of recombinant IFN-gamma to anti-IL-12-treated mice was able to restore host resistance, granuloma formation, and expression of major histocompatibility complex class II antigens in F4/80(+) and CD11b+ spleen cells... - Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutationDavid A Chalton
Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, United Kingdom
Infect Immun 74:6624-31. 2006..The use of circular permutation in vaccine design has not been reported previously... - Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritisAlexei von Delwig
Newcastle University, Newcastle upon Tyne, UK
Arthritis Rheum 62:143-9. 2010..The aim of this study was to investigate whether T cells specific for citrullinated epitopes from self proteins are present in patients with RA... - Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic miceJulie A Musson
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Infect Immun 78:4356-62. 2010.... - NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2Karen P Fraser
Department of Microbiology and Immunology, The Medical School, Newcastle, GB
Eur J Immunol 32:868-78. 2002..1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors, but had little or no effect on the expression of NKRP1 molecules... - LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cellsAmy E Anderson
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
J Leukoc Biol 85:243-50. 2009..Our finding that LPS activation is essential for inducing migratory and antigen-presenting activity in tolDC is important for optimizing their therapeutic potential... - Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayersMbithe Mutunga
School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Vaccine 22:4124-31. 2004.... - Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin BMatthew D Baker
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
J Biol Chem 277:2756-62. 2002..We present a detailed comparison of the mutant structure determined at 2.0 A with the previously reported native SEB and SEB-TCR V(beta) complex structures...