Stephen M Richardson

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells
    Francois N K Kwong
    Center for Molecular Orthopaedics, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R65. 2008
  2. ncbi Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
    Stephen M Richardson
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, UK
    Arthritis Res Ther 11:R126. 2009
  3. ncbi Tissue engineering today, not tomorrow
    Stephen M Richardson
    Division of Regenerative Medicine, University of Manchester, Manchester, UK
    Regen Med 2:91-4. 2007
  4. ncbi Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies
    S M Richardson
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Histol Histopathol 22:1033-41. 2007
  5. ncbi Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1alpha in normal and degenerate human intervertebral disc
    S M Richardson
    Tissue Injury and Repair Group, Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Histochem Cell Biol 129:503-11. 2008
  6. ncbi Stem cell regeneration of degenerated intervertebral discs: current status
    Stephen M Richardson
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Curr Pain Headache Rep 12:83-8. 2008
  7. ncbi Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
    Ben M Minogue
    Tissue Injury and Repair, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Arthritis Res Ther 12:R22. 2010
  8. ncbi Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype
    Sandra Strassburg
    Regenerative Medicine, School of Biomedicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Regen Med 5:701-11. 2010
  9. ncbi Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation
    Ben M Minogue
    University of Manchester, Manchester, UK
    Arthritis Rheum 62:3695-705. 2010
  10. ncbi Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system
    Michael R Fraylich
    Biomaterial Science Group, School of Materials, The University of Manchester, Grosvenor Street, Manchester M17HS, UK
    J Colloid Interface Sci 344:61-9. 2010

Collaborators

Detail Information

Publications20

  1. ncbi Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells
    Francois N K Kwong
    Center for Molecular Orthopaedics, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R65. 2008
    ....
  2. ncbi Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
    Stephen M Richardson
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, UK
    Arthritis Res Ther 11:R126. 2009
    ....
  3. ncbi Tissue engineering today, not tomorrow
    Stephen M Richardson
    Division of Regenerative Medicine, University of Manchester, Manchester, UK
    Regen Med 2:91-4. 2007
  4. ncbi Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies
    S M Richardson
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Histol Histopathol 22:1033-41. 2007
    ..This review covers these key areas and gives an overview of the recent developments in the fields of biomaterials, cell biology and tissue engineering of the IVD...
  5. ncbi Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1alpha in normal and degenerate human intervertebral disc
    S M Richardson
    Tissue Injury and Repair Group, Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Histochem Cell Biol 129:503-11. 2008
    ..This study demonstrates that NP and AF cells have different GLUT expression profiles that suggest regional differences in the metabolic nature of the human IVD and that this environment changes during degeneration...
  6. ncbi Stem cell regeneration of degenerated intervertebral discs: current status
    Stephen M Richardson
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Curr Pain Headache Rep 12:83-8. 2008
    ..Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future...
  7. ncbi Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
    Ben M Minogue
    Tissue Injury and Repair, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Arthritis Res Ther 12:R22. 2010
    ....
  8. ncbi Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype
    Sandra Strassburg
    Regenerative Medicine, School of Biomedicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Regen Med 5:701-11. 2010
    ..Here, we investigate the differences in interaction between human MSCs and NP cells from both nondegenerate and degenerate discs during in vitro co-culture with direct cell-cell contact...
  9. ncbi Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation
    Ben M Minogue
    University of Manchester, Manchester, UK
    Arthritis Rheum 62:3695-705. 2010
    ....
  10. ncbi Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system
    Michael R Fraylich
    Biomaterial Science Group, School of Materials, The University of Manchester, Grosvenor Street, Manchester M17HS, UK
    J Colloid Interface Sci 344:61-9. 2010
    ..The results suggest that this general family of biodegradable thermogelling PLGA dispersions, introduced here for the first time, may have longer-term application as an injectable colloidal cell delivery system...
  11. ncbi The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffolds
    Stephen M Richardson
    UK Centre for Tissue Engineering, Division of Laboratory and Regenerative Medicine, Stopford Building, University of Manchester, Oxford Rd, Manchester M13 9PT, UK
    Biomaterials 27:4069-78. 2006
    ..We are therefore proposing pre-differentiation of human MSCs and seeding on porous, biodegradable 3D synthetic polymer scaffolds as a realistic tissue engineering strategy for regeneration of the degenerate human IVD...
  12. ncbi Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels
    Stephen M Richardson
    UK Centre for Tissue Regeneration, Tissue Injury and Repair Group, University of Manchester, Manchester, UK
    Biomaterials 29:85-93. 2008
    ..These results therefore suggest that MSC-seeded C/Gp gels could be used clinically for the regeneration of the degenerate human IVD...
  13. ncbi Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
    Stephen M Richardson
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    J Cell Physiol 222:23-32. 2010
    ....
  14. ncbi Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration
    Aneta J Pockert
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:482-91. 2009
    ..The present study was undertaken to investigate the expression of the recognized aggrecanases and their inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP-3), in human intervertebral disc tissue...
  15. ncbi Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
    Sotonye K Tolofari
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Arthritis Res Ther 12:R1. 2010
    ....
  16. ncbi Introducing chemical functionality in Fmoc-peptide gels for cell culture
    Vineetha Jayawarna
    School of Materials and Manchester Interdisciplinary Biocentre, Materials Science Centre, The University of Manchester, Grosvenor Street, Manchester M1 7HS, UK
    Acta Biomater 5:934-43. 2009
    ..These results demonstrate that introduction of chemical functionality into Fmoc-peptide scaffolds may provide gels with tunable chemical and mechanical properties for in vitro cell culture...
  17. ncbi Bi-directional exchange of membrane components occurs during co-culture of mesenchymal stem cells and nucleus pulposus cells
    Sandra Strassburg
    Regenerative Medicine, School of Biomedicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, United Kingdom
    PLoS ONE 7:e33739. 2012
    ..Thus, this study highlights bi-directional intercellular transfer of membrane components as a possible mechanism of cellular communication between MSC and NP cells...
  18. ncbi Intervertebral disc cell-mediated mesenchymal stem cell differentiation
    Stephen M Richardson
    UK Centre for Tissue Engineering, Division of Laboratory and Regenerative Medicine, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Stem Cells 24:707-16. 2006
    ....
  19. ncbi Aquaporin expression in the human intervertebral disc
    S M Richardson
    Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9PT, UK
    J Mol Histol 39:303-9. 2008
    ..The decrease in expression of AQPs from the NP to the outer AF may signify changes in cellular phenotype in response to differences in mechanbiology, osmolarity and hydration between the gelatinous NP and the fibrous AF...
  20. ncbi Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration
    R Ali
    Department of Tissue Injury and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom
    Biotech Histochem 83:239-45. 2008
    ..We suggest that CTGF may play a role in angiogenesis in the human degenerated IVD...