Lesley E Rhodes

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial
    Lesley E Rhodes
    Department of Dermatology, Royal Liverpool University Hospital, Liverpool, England
    Arch Dermatol 140:17-23. 2004
  2. ncbi Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma
    Lesley E Rhodes
    Photobiology Unit, Department of Dermatology, University of Manchester, Salford Royal Foundation Hospital, Manchester M6 8HD, England
    Arch Dermatol 143:1131-6. 2007
  3. ncbi The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases
    Lesley E Rhodes
    Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal NHS Foundation Hospital, Manchester, M6 8HD, UK
    FASEB J 23:3947-56. 2009
  4. ncbi Recommended summer sunlight exposure levels can produce sufficient (> or =20 ng ml(-1)) but not the proposed optimal (> or =32 ng ml(-1)) 25(OH)D levels at UK latitudes
    Lesley E Rhodes
    Photobiology Unit, Dermatological Sciences, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester, UK
    J Invest Dermatol 130:1411-8. 2010
  5. ncbi Recommended summer sunlight exposure amounts fail to produce sufficient vitamin D status in UK adults of South Asian origin
    Mark D Farrar
    Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, United Kingdom
    Am J Clin Nutr 94:1219-24. 2011
  6. ncbi The vitamin D debate: translating controlled experiments into reality for human sun exposure times
    Ann R Webb
    School of Earth Atmospheric and Environmental Sciences, University of Manchester, Manchester, UK
    Photochem Photobiol 87:741-5. 2011
  7. ncbi Severely photosensitive psoriasis: a phenotypically defined patient subset
    Kirsty J Rutter
    Department of Dermatological Sciences, School of Translational Medicine, University of Manchester, Manchester M6 8HD, UK
    J Invest Dermatol 129:2861-7. 2009
  8. ncbi Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo
    Hassan Shahbakhti
    Photobiology Unit, Dermatology Centre, University of Manchester, Manchester M6 8HD, UK
    Photochem Photobiol 80:231-5. 2004
  9. ncbi Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response
    Rebecca C C Brooke
    Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal Hospital, Manchester, UK
    J Invest Dermatol 126:2296-301. 2006
  10. ncbi Psychologic distress in polymorphous light eruption and its relationship to patients' beliefs about their condition
    Helen L Richards
    Academic Division of Clinical Psychology, University of Manchester, Manchester, United Kingdom
    J Am Acad Dermatol 56:426-31. 2007

Collaborators

Detail Information

Publications20

  1. ncbi Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial
    Lesley E Rhodes
    Department of Dermatology, Royal Liverpool University Hospital, Liverpool, England
    Arch Dermatol 140:17-23. 2004
    ..CONCLUSIONS: Methyl aminolevulinate PDT is an effective treatment for nodular BCC, and while there is a trend for higher recurrence with this modality, it conveys the advantage over surgery of better cosmesis...
  2. ncbi Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma
    Lesley E Rhodes
    Photobiology Unit, Department of Dermatology, University of Manchester, Salford Royal Foundation Hospital, Manchester M6 8HD, England
    Arch Dermatol 143:1131-6. 2007
    ..To compare 5-year lesion recurrence rates in primary nodular basal cell carcinoma treated with topical methyl aminolevulinate photodynamic therapy (PDT) or simple excision surgery...
  3. ncbi The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases
    Lesley E Rhodes
    Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal NHS Foundation Hospital, Manchester, M6 8HD, UK
    FASEB J 23:3947-56. 2009
    ..Sunburn is characterized by overlapping sequential profiles of increases in COX products followed by LOX products that may regulate subsequent events and ultimately its resolution...
  4. ncbi Recommended summer sunlight exposure levels can produce sufficient (> or =20 ng ml(-1)) but not the proposed optimal (> or =32 ng ml(-1)) 25(OH)D levels at UK latitudes
    Lesley E Rhodes
    Photobiology Unit, Dermatological Sciences, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester, UK
    J Invest Dermatol 130:1411-8. 2010
    ....
  5. ncbi Recommended summer sunlight exposure amounts fail to produce sufficient vitamin D status in UK adults of South Asian origin
    Mark D Farrar
    Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, United Kingdom
    Am J Clin Nutr 94:1219-24. 2011
    ..The national guidance provided on amounts of sunlight exposure in the United Kingdom is for the light-skinned population, and in the absence of dedicated information, darker-skinned people may attempt to follow this guidance...
  6. ncbi The vitamin D debate: translating controlled experiments into reality for human sun exposure times
    Ann R Webb
    School of Earth Atmospheric and Environmental Sciences, University of Manchester, Manchester, UK
    Photochem Photobiol 87:741-5. 2011
    ..While both sun exposure conditions and human skin responses are variable in real life, these quantitative findings provide a guide for authorities devising sunlight exposure recommendations...
  7. ncbi Severely photosensitive psoriasis: a phenotypically defined patient subset
    Kirsty J Rutter
    Department of Dermatological Sciences, School of Translational Medicine, University of Manchester, Manchester M6 8HD, UK
    J Invest Dermatol 129:2861-7. 2009
    ..Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase...
  8. ncbi Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo
    Hassan Shahbakhti
    Photobiology Unit, Dermatology Centre, University of Manchester, Manchester M6 8HD, UK
    Photochem Photobiol 80:231-5. 2004
    ..Hence, in healthy skin in vivo, there was no evidence that reduction of the sunburn response by EPA is mediated by the proinflammatory cytokines examined; abrogation of UV-B-generated PGE(2) may play a role...
  9. ncbi Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response
    Rebecca C C Brooke
    Photobiology Unit, Dermatological Sciences, University of Manchester, Salford Royal Hospital, Manchester, UK
    J Invest Dermatol 126:2296-301. 2006
    ..Thus, two discrete acute inflammatory responses to topical ALA-PDT occur in human skin; histamine mediates the immediate response, but does not appear involved in the delayed phototoxicity...
  10. ncbi Psychologic distress in polymorphous light eruption and its relationship to patients' beliefs about their condition
    Helen L Richards
    Academic Division of Clinical Psychology, University of Manchester, Manchester, United Kingdom
    J Am Acad Dermatol 56:426-31. 2007
    ..Skin disease can cause psychologic difficulties, but information is lacking on the emotional impact of the common photosensitivity condition, polymorphous light eruption (PMLE)...
  11. ncbi Positive response of a recurrent keloid scar to topical methyl aminolevulinate-photodynamic therapy
    Zhuxiang Nie
    Photobiology Unit, Dermatology Centre, Salford Royal NHS Foundation Hospital, Stott Lane, Salford, Manchester M68HD, UK
    Photodermatol Photoimmunol Photomed 26:330-2. 2010
    ..This case report presents PDT as a potential treatment option for persistent keloid lesions unresponsive to conventional scar modulation therapies and suggests a need for further research in this area...
  12. ncbi Omega-3 polyunsaturated fatty acids: photoprotective macronutrients
    Suzanne M Pilkington
    Dermatological Sciences, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester, UK
    Exp Dermatol 20:537-43. 2011
    ....
  13. ncbi Allergic contact dermatitis to methyl aminolevulinate (Metvix) cream used in photodynamic therapy
    Matthew J Harries
    The Dermatology Centre, The University of Manchester, Hope Hospital, Stott Lane, Salford, Manchester, UK
    Photodermatol Photoimmunol Photomed 23:35-6. 2007
    ..Contact allergy to the prodrug is rarely reported. We report a case of allergic contact dermatitis to methyl aminolevulinate cream used in PDT...
  14. ncbi Photoaggravated hand and foot psoriasis
    Rajani Nalluri
    Photobiology Unit, Dermatology Centre, University of Manchester, Manchester Academic Health Science Centre, Salford Royal Foundation Hospital, Manchester, UK
    Photodermatol Photoimmunol Photomed 26:261-2. 2010
    ..The onset of photosensitivity should be suspected in patients with hand and foot psoriasis showing a similar change in distribution...
  15. ncbi Treatment of polymorphic light eruption
    Tsui C Ling
    Photobiology Unit, Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK
    Photodermatol Photoimmunol Photomed 19:217-27. 2003
    ..While sun protection, corticosteroids and desensitization phototherapy are the mainstays of management, a range of anti-inflammatory and immunomodulatory agents are reported...
  16. ncbi Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers
    Lesley E Rhodes
    Photobiology Unit, Dermatology Centre, University of Manchester, UK
    Carcinogenesis 24:919-25. 2003
    ..e. sunburn, UVR-induced p53 in skin and strand breaks in PBL, indicate protection by dietary EPA against acute UVR-induced genotoxicity; longer-term supplementation might reduce skin cancer in humans...
  17. ncbi Polymorphic light eruption: does a neutrophil defect contribute to the pathogenesis?
    Lesley E Rhodes
    Photobiology Unit, The Dermatology Centre, University of Manchester School of Medicine, Hope Hospital, Manchester, UK
    J Invest Dermatol 123:xiii-xv. 2004
  18. ncbi The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancer
    Homer S Black
    Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Detect Prev 30:224-32. 2006
    ..Supplementary omega-3 FA significantly reduces the level of pro-inflammatory and immunosuppressive PGE(2) levels in Ultraviolet B-irradiated human skin...
  19. ncbi Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts
    Amy Storey
    Department of Medicine, University of Liverpool, Liverpool, UK
    J Invest Dermatol 124:248-55. 2005
    ..001). Hence both n-3 PUFA inhibit production of UVB- and TNF-alpha-induced IL-8 in skin cells; this may be important in the photoprotective and other anti-inflammatory effects conferred by these agents...
  20. ncbi Preventive oncology
    Lesley E Rhodes
    Lancet 363:1736-7. 2004