David A Rhodes

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-gamma inducible tripartite motif protein associated with membrane proximal structures
    Davd A Rhodes
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge UK
    Immunology 106:246-56. 2002
  2. ncbi The cluster of BTN genes in the extended major histocompatibility complex
    D A Rhodes
    Department of Immunology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Genomics 71:351-62. 2001
  3. ncbi Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?
    David A Rhodes
    Cambridge Institute for Medical Research, Addensbrookes Hospital, Cambridge, UK
    Immunology 116:411-7. 2005
  4. ncbi BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation
    Isobel A Smith
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 184:3514-25. 2010
  5. ncbi Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
    Leo C James
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Proc Natl Acad Sci U S A 104:6200-5. 2007
  6. ncbi TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Mol Immunol 44:2406-14. 2007
  7. ncbi Ubiquitination of lysine-331 by Kaposi's sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradation
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:16240-5. 2010
  8. ncbi Intracellular antibody-mediated immunity and the role of TRIM21
    William A McEwan
    MRC Laboratory of Molecular Biology, PNAC Division, Cambridge, UK
    Bioessays 33:803-9. 2011

Detail Information

Publications8

  1. ncbi The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-gamma inducible tripartite motif protein associated with membrane proximal structures
    Davd A Rhodes
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge UK
    Immunology 106:246-56. 2002
    ..The majority of these autoimmune sera also immunoprecipitated the Ro52-related molecule RNF15. A possible role for Ro52 protein in alterations of plasma membranes during cellular activation or apoptosis is discussed...
  2. ncbi The cluster of BTN genes in the extended major histocompatibility complex
    D A Rhodes
    Department of Immunology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Genomics 71:351-62. 2001
    ..Most transcripts of BTN2 subfamily genes contained this domain, whereas BTN3 genes did not. Using immunofluorescence, we showed surface expression of BTN-green fluorescent protein fusions in mammalian cell transfectants...
  3. ncbi Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?
    David A Rhodes
    Cambridge Institute for Medical Research, Addensbrookes Hospital, Cambridge, UK
    Immunology 116:411-7. 2005
    ..The combination of SPRY and PRY to produce B30.2 domains may have been selected and maintained as a component of immune defence...
  4. ncbi BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation
    Isobel A Smith
    Immunology Division, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 184:3514-25. 2010
    ..These data are consistent with a coinhibitory role for mouse BTNs, including BTN1A1, the BTN expressed in the lactating mammary gland and on milk lipid droplets...
  5. ncbi Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
    Leo C James
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Proc Natl Acad Sci U S A 104:6200-5. 2007
    ....
  6. ncbi TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Mol Immunol 44:2406-14. 2007
    ..protein G. The data suggest that the normal function of TRIM21 involves regulation of IgG functions and that TRIM/B30.2 molecules may have broader and unsuspected roles in innate immunity, beyond that of retroviral restriction...
  7. ncbi Ubiquitination of lysine-331 by Kaposi's sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradation
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:16240-5. 2010
    ..The results show regulated expression of HFE by ubiquitination, consistent with a role in cellular iron homeostasis, a molecular mechanism targeted by KSHV to achieve a positive iron balance...
  8. ncbi Intracellular antibody-mediated immunity and the role of TRIM21
    William A McEwan
    MRC Laboratory of Molecular Biology, PNAC Division, Cambridge, UK
    Bioessays 33:803-9. 2011
    ..Finally, we discuss the conceptual implications of intracellular antibody immunity and how it alters our view of the discrete separation of extracellular and intracellular environments...