A G Renehan

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, UK
    Lancet 371:569-78. 2008
  2. ncbi Insulin analogues and cancer risk: the emergence of second-generation studies
    A G Renehan
    School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Diabetologia 55:7-9. 2012
  3. ncbi Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Surg 92:605-14. 2005
  4. ncbi Preventing cancer, cardiovascular disease, and diabetes
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Lancet 365:1449-51. 2005
  5. ncbi Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:273-8. 2006
  6. ncbi Obesity and cancer risk: the role of the insulin-IGF axis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Trends Endocrinol Metab 17:328-36. 2006
  7. ncbi The effects of sex steroid replacement therapy on an expanded panel of IGF-related peptides
    Andrew G Renehan
    Department of Surgery, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 17:210-9. 2007
  8. ncbi Colorectal cancer prevention: choosing the most effective population strategy using bio-mathematical approaches
    A G Renehan
    Department of Surgery, Academic Division of Cancer Studies, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Colorectal Dis 9:393-6. 2007
  9. ncbi Insulin and Cancer: Report of the Proceedings of the First International Workshop, October 27-28, 2007, Düsseldorf, Germany
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, Manchester, UK
    Pediatr Endocrinol Rev 5:810-6. 2008
  10. ncbi Obesity and cancer: pathophysiological and biological mechanisms
    Andrew G Renehan
    Department of Surgery, School of Cancer and Imaging Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Arch Physiol Biochem 114:71-83. 2008

Detail Information

Publications39

  1. ncbi Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, UK
    Lancet 371:569-78. 2008
    ..We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups...
  2. ncbi Insulin analogues and cancer risk: the emergence of second-generation studies
    A G Renehan
    School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Diabetologia 55:7-9. 2012
    ..A list of preferred qualities for pharmaco-epidemiological studies is presented...
  3. ncbi Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Surg 92:605-14. 2005
    ..Salvage surgery for anal cancer is usually reserved for local disease failure, but issues relating to the prediction of local failure and surgical outcome are ill defined...
  4. ncbi Preventing cancer, cardiovascular disease, and diabetes
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Lancet 365:1449-51. 2005
  5. ncbi Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Endocr Relat Cancer 13:273-8. 2006
    ..The reasons are complex and include differences in study design, lack of standardisation between assays, and variations in IGFBP-3 proteolytic activity--these are discussed in this commentary...
  6. ncbi Obesity and cancer risk: the role of the insulin-IGF axis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Trends Endocrinol Metab 17:328-36. 2006
    ..As the prevalence of EBW increases to epidemic proportions, untangling the links between EBW and the insulin-IGF axis and its wider molecular interactions will become increasingly important in the development of preventive strategies...
  7. ncbi The effects of sex steroid replacement therapy on an expanded panel of IGF-related peptides
    Andrew G Renehan
    Department of Surgery, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 17:210-9. 2007
    ..The aim of this study was to clarify these relationships, as circulating IGF-related peptides are potential surrogates of predisposition to common chronic diseases...
  8. ncbi Colorectal cancer prevention: choosing the most effective population strategy using bio-mathematical approaches
    A G Renehan
    Department of Surgery, Academic Division of Cancer Studies, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Colorectal Dis 9:393-6. 2007
    ..Examples are discussed of the potential population effects of an agent that modulates cell kinetics, such as aspirin, vs one that merely reduces mutational rates...
  9. ncbi Insulin and Cancer: Report of the Proceedings of the First International Workshop, October 27-28, 2007, Düsseldorf, Germany
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, Manchester, UK
    Pediatr Endocrinol Rev 5:810-6. 2008
  10. ncbi Obesity and cancer: pathophysiological and biological mechanisms
    Andrew G Renehan
    Department of Surgery, School of Cancer and Imaging Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Arch Physiol Biochem 114:71-83. 2008
    ....
  11. ncbi Acromegaly, growth hormone and cancer risk
    Andrew G Renehan
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Best Pract Res Clin Endocrinol Metab 22:639-57. 2008
    ..This emphasizes the need for patient selection balanced against the known morbidity of untreated GH deficiency...
  12. ncbi Incident cancer burden attributable to excess body mass index in 30 European countries
    Andrew G Renehan
    Department of Surgery, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Int J Cancer 126:692-702. 2010
    ..The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer...
  13. ncbi Foreword: Implementing cancer prevention in Europe
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, School of Cancer and enabling Sciences, University of Manchester, UK
    Eur J Cancer 46:2523-4. 2010
    ..The Special Issue is supported by focused evidence-based case studies of how these processes might be best taken forward...
  14. ncbi Interpreting the epidemiological evidence linking obesity and cancer: A framework for population-attributable risk estimations in Europe
    Andrew G Renehan
    Department of Surgery, the Christie NHS Foundation Trust, School of Cancer and enabling Sciences, University of Manchester, UK
    Eur J Cancer 46:2581-92. 2010
    ..Overall, this framework gives conservative estimates for PAR - nonetheless, the numbers of avoidable cancers across Europe through avoidance of excess weight are substantial...
  15. ncbi Determination of large bowel length and loop complexity in patients with acromegaly undergoing screening colonoscopy
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 62:323-30. 2005
    ..In turn, large bowel dimensions may be increased in these patients, factors that predict for increased risk of serious complications such as perforation...
  16. ncbi The prevalence and characteristics of colorectal neoplasia in acromegaly
    A G Renehan
    Department of Surgery, Christie Hospital National Health Service Trust, Manchester, United Kingdom
    J Clin Endocrinol Metab 85:3417-24. 2000
    ..This study has failed to demonstrate an increased prevalence of neoplasia in acromegalic patients compared with the expected prevalence in the general population and questions the need for an aggressive colonoscopic screening policy...
  17. ncbi Determination of IGF-I, IGF-II, IGFBP-2, and IGFBP-3 levels in serum and plasma: comparisons using the Bland-Altman method
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Growth Horm IGF Res 13:341-6. 2003
    ..These findings emphasize the need to standardize methods of collecting blood samples in future epidemiological studies and trials...
  18. ncbi Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: insights into the regulation of these peptides
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Clin Endocrinol (Oxf) 55:469-75. 2001
    ..This study compared serum IGF-II and IGFBP-2 distributions between acromegalics and a large normal adult population to explore possible determinants...
  19. ncbi Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Horm Metab Res 35:712-25. 2003
    ..From a clinical perspective, it seems reasonable to consider a once-only colonoscopic screening at approximately age 55 years, but potential risks and benefits should be balanced...
  20. ncbi Cost effectiveness analysis of intensive versus conventional follow up after curative resection for colorectal cancer
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Withington, Manchester M20 4BX
    BMJ 328:81. 2004
    ..To determine the cost effectiveness of intensive follow up compared with conventional follow up in patients with colorectal cancer...
  21. ncbi Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Lancet 363:1346-53. 2004
    ..Circulating concentrations of IGF-I might be associated with an increased risk of cancer, whereas IGFBP-3 concentrations could be associated with a decreased cancer risk...
  22. ncbi High-risk colorectal adenomas and serum insulin-like growth factors
    A G Renehan
    Department of Surgery, Cancer Research Campaign Department of Epithelial Biology, Paterson Institute for Cancer Research, Manchester, UK
    Br J Surg 88:107-13. 2001
    ..This study investigated the hypothesis that circulating levels of insulin-like growth factor (IGF) I and its main binding protein (IGFBP-3) predict for the presence of colorectal adenomas, surrogate markers of colorectal cancer risk...
  23. ncbi The effect of cigarette smoking use and cessation on serum insulin-like growth factors
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 91:1525-31. 2004
    ..For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations...
  24. ncbi Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Br J Cancer 92:430-3. 2005
    ....
  25. ncbi Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials
    Andrew G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester M20 4BX
    BMJ 324:813. 2002
    ..To review the evidence from clinical trials of follow up of patients after curative resection for colorectal cancer...
  26. ncbi Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, M20 4BX
    Br J Cancer 83:1344-50. 2000
    ..We conclude that the serum IGF-II and IGFBP-2 profiles may provide insights into underlying biological mechanisms, and that serum IGFBP-2 may have an adjunct role in cancer surveillance in patients with colorectal cancer...
  27. ncbi Treatments and outcomes of peritoneal surface tumors through a centralized national service (United kingdom)
    S Rout
    Peritoneal Tumour Service, Department of Surgery, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Dis Colon Rectum 52:1705-14. 2009
    ..To better define treatment pathways, five-year results in patients referred to one of two centralized national treatment centers in the United Kingdom were analyzed...
  28. ncbi A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei
    A L Farquharson
    Peritoneal Tumour Service, Department of Surgery, Christie Hospital NHS Foundation Trust, Manchester, UK
    Br J Cancer 99:591-6. 2008
    ..This is the first trial to demonstrate an apparent benefit of systemic chemotherapy in patients with advanced unresectable PMP...
  29. ncbi Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly
    C Parkinson
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 57:59-64. 2002
    ..These data have important implications for the use of serum IGF-I and GH as markers of disease activity in acromegaly...
  30. ncbi Biological mechanisms linking obesity and cancer risk: new perspectives
    Darren L Roberts
    Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, the Christie NHS Foundation Trust, Manchester, UK
    Annu Rev Med 61:301-16. 2010
    ....
  31. ncbi Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer
    M M Seenath
    Clinical and Experimental Pharmacology, Paterson Institute of Cancer Research, Manchester, UK
    Br J Cancer 99:459-63. 2008
    ..04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain...
  32. ncbi Clinico-pathological and treatment-related factors influencing survival in parotid cancer
    A G Renehan
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Br J Cancer 80:1296-300. 1999
    ..Post-operative RT contributes significantly to locoregional control and probably confers some survival advantage in high-risk patients...
  33. ncbi A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei
    R Bibi
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, Manchester, UK
    Br J Cancer 95:1258-64. 2006
    ....
  34. ncbi The relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestine
    A G Renehan
    EpiStem Ltd, Manchester, United Kingdom
    Can J Gastroenterol 15:166-76. 2001
    ..The importance of understanding the molecular biology of apoptotic pathways in cancer therapy and future directions are also addressed...
  35. ncbi Body mass index, hormone replacement therapy, and endometrial cancer risk: a meta-analysis
    Emma J Crosbie
    Gynaecology Oncology Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
    Cancer Epidemiol Biomarkers Prev 19:3119-30. 2010
    ..Body mass index (BMI) is a risk factor for endometrial cancer. We quantified the risk and investigated whether the association differed by use of hormone replacement therapy (HRT), menopausal status, and histologic type...
  36. ncbi Acromegaly and colorectal cancer: risk assessment should be based on population-based studies
    Andrew G Renehan
    J Clin Endocrinol Metab 87:1909; author reply 1909. 2002
  37. ncbi IGF-I, IGF binding protein-3 and breast cancer risk: comparison of 3 meta-analyses
    Andrew G Renehan
    Int J Cancer 115:1006-7; author reply 1008. 2005
  38. ncbi Physical activity before and after diagnosis of colorectal cancer: disease risk, clinical outcomes, response pathways and biomarkers
    David J Harriss
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK
    Sports Med 37:947-60. 2007
    ..Research evidence is, however, limited as to whether these markers are beneficially affected by physical activity, either before or after diagnosis of colorectal cancer...
  39. ncbi Diabetes, insulin therapy, and colorectal cancer
    Andrew G Renehan
    BMJ 330:551-2. 2005