Christopher W G Redman

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Microparticles and immunomodulation in pregnancy and pre-eclampsia
    C W G Redman
    University of Oxford, Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Reprod Immunol 76:61-7. 2007
  2. ncbi The endoplasmic reticulum stress of placental impoverishment
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 173:311-4. 2008
  3. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
  4. ncbi Placental stress and pre-eclampsia: a revised view
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 30:S38-42. 2009
  5. ncbi Immunology of pre-eclampsia
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Am J Reprod Immunol 63:534-43. 2010
  6. ncbi Circulating microparticles in normal pregnancy and pre-eclampsia
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 29:S73-7. 2008
  7. ncbi NK cells and human pregnancy--an inflammatory view
    Ian L Sargent
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK, OX3 9DU
    Trends Immunol 27:399-404. 2006
  8. ncbi Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells--implication for placental cell fusion
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    FEBS J 274:2715-27. 2007
  9. ncbi Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochim Biophys Acta 1768:401-10. 2007
  10. ncbi Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Nanomedicine 7:780-8. 2011

Collaborators

Detail Information

Publications24

  1. ncbi Microparticles and immunomodulation in pregnancy and pre-eclampsia
    C W G Redman
    University of Oxford, Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Reprod Immunol 76:61-7. 2007
    ..Deletion of activate T cells which express Fas ligand by Fas-expressing exosomes derived from trophoblast may contribute to immunoregulation necessary for normal pregnancy...
  2. ncbi The endoplasmic reticulum stress of placental impoverishment
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 173:311-4. 2008
  3. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
    ..This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings...
  4. ncbi Placental stress and pre-eclampsia: a revised view
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 30:S38-42. 2009
    ..These may also contribute to the final inflammatory syndrome. We propose a modified version of the two-stage model for pre-eclampsia...
  5. ncbi Immunology of pre-eclampsia
    Christopher W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Am J Reprod Immunol 63:534-43. 2010
    ..For the first time, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier. Now, the challenge is to prove the detail...
  6. ncbi Circulating microparticles in normal pregnancy and pre-eclampsia
    C W G Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Placenta 29:S73-7. 2008
    ..However inhibitory activity has also been ascribed to trophoblast derived exosomes. In vitro, they down-regulate T cell activity, a T cell change that has been repeatedly observed, ex vivo, during normal pregnancy...
  7. ncbi NK cells and human pregnancy--an inflammatory view
    Ian L Sargent
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK, OX3 9DU
    Trends Immunol 27:399-404. 2006
    ..We suggest novel ways in which the trophoblast might stimulate the maternal systemic inflammatory response, and how dysfunctional NK-cell activation could result in the maternal syndrome of pre-eclampsia...
  8. ncbi Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells--implication for placental cell fusion
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    FEBS J 274:2715-27. 2007
    ....
  9. ncbi Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line
    Paola Dalton
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochim Biophys Acta 1768:401-10. 2007
    ..The results thus suggest that the function of CD98 in cell fusion is distinct from its role in cellular nutrient delivery...
  10. ncbi Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Nanomedicine 7:780-8. 2011
    ....
  11. ncbi Preeclampsia and the systemic inflammatory response
    Christopher W G Redman
    Department of Obstetric Medicine, University of Oxford, Oxford, UK
    Semin Nephrol 24:565-70. 2004
    ..The clinical implications of these concepts are discussed...
  12. ncbi Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre-eclampsia may be mediated by natural killer cells
    Angela M Borzychowski
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 35:3054-63. 2005
    ..001 and p <0.01, respectively) and pre-eclamptic women (p <0.05). These results confirm that immunoregulation occurs in pregnancy, but suggest a dominant role of the innate rather than the adaptive immune system...
  13. ncbi Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity
    Chris Gardiner
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e26313. 2011
    ..It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could contribute to the haemostatic activation observed in pre-eclampsia...
  14. ncbi RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells
    Gavin P Collett
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e30453. 2012
    ....
  15. ncbi Downregulation of caveolin-1 enhances fusion of human BeWo choriocarcinoma cells
    Gavin P Collett
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10529. 2010
    ..Caveolin-1 has been shown to be expressed in human villous cytotrophoblast and to be downregulated during fusion into syncytiotrophoblast but it is unclear whether it plays a role in this process...
  16. ncbi ST2 and IL-33 in pregnancy and pre-eclampsia
    Ingrid Granne
    Oxford Fertility Unit, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e24463. 2011
    ..These results suggest that sST2 may play a significant role in pregnancies complicated by pre-eclampsia and increased sST2 could contribute to the type 1 bias seen in this disorder...
  17. ncbi Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia
    Yoshiki Kudo
    Department of Human Anatomy and Genetics, University of Oxford, United Kingdom
    Am J Obstet Gynecol 188:719-26. 2003
    ..Therefore, we studied tryptophan metabolism in pregnant women, with or without preeclampsia, as well as expression and function of placental indoleamine 2,3-dioxygenase...
  18. ncbi Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles
    Sarah J Germain
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 178:5949-56. 2007
    ..Circulating STBMs bind to monocytes and stimulate the production of inflammatory cytokines. It is concluded that they are potential contributors to altered systemic inflammatory responsiveness in pregnancy and pre-eclampsia...
  19. ncbi Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom
    Margaret P Rayman
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    Am J Obstet Gynecol 189:1343-9. 2003
    ....
  20. ncbi Preeclampsia with abnormal liver function tests is associated with cholestasis in a subgroup of cases
    Dimitrios G Goulis
    Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, UK
    Hypertens Pregnancy 23:19-27. 2004
    ..As some women with preeclampsia and abnormal liver function complain of pruritus, we recommend checking the serum bile acids in this group of women. If these acids are raised the fetal prognosis may be adversely affected...
  21. ncbi Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  22. ncbi Detection and identification of novel metabolomic biomarkers in preeclampsia
    Louise C Kenny
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Reprod Sci 15:591-7. 2008
    ..The identity of these metabolites provides new insights into the pathology of this condition and raises the possibility of the development of a predictive test...
  23. ncbi Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system
    Warwick B Dunn
    Manchester Centre for Integrative Systems Biology, School of Chemistry, The Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 871:288-98. 2008
    ..The data were used to indicate possible biomarkers of pre-eclampsia and showed both the instruments and XCMS to be applicable to the reproducible and valid detection of disease biomarkers present in serum...
  24. ncbi Abnormal iron parameters in the pregnancy syndrome preeclampsia
    Margaret P Rayman
    School of Biomedical and Life Sciences, University of Surrey, Guildford, United Kongdom
    Am J Obstet Gynecol 187:412-8. 2002
    ....