Colin Ratledge

Summary

Affiliation: University of Hull
Country: UK

Publications

  1. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
  2. ncbi Iron, mycobacteria and tuberculosis
    Colin Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Tuberculosis (Edinb) 84:110-30. 2004
  3. ncbi Iron metabolism and infection
    Colin Ratledge
    Department of Biological Sciences, University of Hull, United Kingdom
    Food Nutr Bull 28:S515-23. 2007
  4. ncbi The distinctiveness of ATP:citrate lyase from Aspergillus nidulans
    Ian P Adams
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Biochim Biophys Acta 1597:36-41. 2002
  5. ncbi Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production
    Colin Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Biochimie 86:807-15. 2004
  6. ncbi Roles of trpE2, entC and entD in salicylic acid biosynthesis in Mycobacterium smegmatis
    Nivedita Nagachar
    Department of Biological Sciences, University of Hull, Hull, UK
    FEMS Microbiol Lett 308:159-65. 2010
  7. ncbi Knocking out salicylate biosynthesis genes in Mycobacterium smegmatis induces hypersensitivity to p-aminosalicylate (PAS)
    Nivedita Nagachar
    Department of Biological Sciences, University of Hull, Hull, UK
    FEMS Microbiol Lett 311:193-9. 2010
  8. ncbi The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms
    Colin Ratledge
    Lipid Research Centre, Department of Biological Sciences, University of Hull, HU6 7RX, United Kingdom
    Adv Appl Microbiol 51:1-51. 2002
  9. ncbi Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration
    Margaret A Holmes
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Structure 13:29-41. 2005
  10. ncbi Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents
    Amruta R Poreddy
    MetaPhore Pharmaceuticals, Inc, 1910 Innerbelt Business Center Drive, Saint Louis, MO 63114, USA
    Bioorg Med Chem Lett 13:2553-6. 2003

Collaborators

Detail Information

Publications13

  1. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..In this way, the biochemistry of the bacterial cell can accommodate the challenges from the host. Agents that interfere with bacterial iron metabolism may prove extremely valuable for chemotherapy of diseases...
  2. ncbi Iron, mycobacteria and tuberculosis
    Colin Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Tuberculosis (Edinb) 84:110-30. 2004
    ....
  3. ncbi Iron metabolism and infection
    Colin Ratledge
    Department of Biological Sciences, University of Hull, United Kingdom
    Food Nutr Bull 28:S515-23. 2007
    ....
  4. ncbi The distinctiveness of ATP:citrate lyase from Aspergillus nidulans
    Ian P Adams
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Biochim Biophys Acta 1597:36-41. 2002
    ..In crude extracts, it was found at high activity (88 micromol min(-1) mg protein(-1)) in glucose-grown cells but only at low activity (10 micromol min(-1) mg protein(-1)) in acetate-grown cells...
  5. ncbi Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production
    Colin Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK
    Biochimie 86:807-15. 2004
    ..This route is discussed. It clearly represents a major departure from conventional fatty acid biosynthesis, possibly as a means of decreasing the amount of NADPH that is needed in the overall process...
  6. ncbi Roles of trpE2, entC and entD in salicylic acid biosynthesis in Mycobacterium smegmatis
    Nivedita Nagachar
    Department of Biological Sciences, University of Hull, Hull, UK
    FEMS Microbiol Lett 308:159-65. 2010
    ..The gene products of both entC and entD are involved in the conversion of isochorismic acid into salicylic acid, and hence correspond to salicylate synthase...
  7. ncbi Knocking out salicylate biosynthesis genes in Mycobacterium smegmatis induces hypersensitivity to p-aminosalicylate (PAS)
    Nivedita Nagachar
    Department of Biological Sciences, University of Hull, Hull, UK
    FEMS Microbiol Lett 311:193-9. 2010
    ..5 ?g mL(-1) increased the accumulation of salicylate with the wild type and mutants. These results support our hypothesis that PAS targets the conversion of salicylate to mycobactin, thus preventing iron acquisition from the host...
  8. ncbi The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms
    Colin Ratledge
    Lipid Research Centre, Department of Biological Sciences, University of Hull, HU6 7RX, United Kingdom
    Adv Appl Microbiol 51:1-51. 2002
  9. ncbi Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration
    Margaret A Holmes
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Structure 13:29-41. 2005
    ..tuberculosis: carboxymycobactins. Siderocalin employs a degenerate recognition mechanism to cross react with these dissimilar types of siderophores, broadening the potential utility of this innate immune defense...
  10. ncbi Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents
    Amruta R Poreddy
    MetaPhore Pharmaceuticals, Inc, 1910 Innerbelt Business Center Drive, Saint Louis, MO 63114, USA
    Bioorg Med Chem Lett 13:2553-6. 2003
    ..The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium...
  11. ncbi Characterization of five novel Pseudomonas aeruginosa cell-surface signalling systems
    María A Llamas
    Department of Medical Microbiology, VU Medical Center, 1081 BT Amsterdam, The Netherlands
    Mol Microbiol 67:458-72. 2008
    ....
  12. ncbi Iron chelation properties of an extracellular siderophore exochelin MN
    Suraj Dhungana
    Department of Chemistry, Duke University, Box 90346, Durham, NC 27708-0346, USA
    J Am Chem Soc 125:7654-63. 2003
    ..The E(1/2) for the Fe(III)ExoMN/Fe(II)ExoMN(-) couple was determined to be -595 mV from quasi-reversible cyclic voltammograms at pH = 10.8, and the pH-dependent E(1/2) profile was used to determine the Fe(II)-ExoMN protonation constants...
  13. ncbi Iron chelation properties of an extracellular siderophore exochelin MS
    Suraj Dhungana
    Department of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, USA
    Inorg Chem 43:6274-83. 2004
    ..The E(1/2) for the Fe(III)-ExoMS/Fe(II)-ExoMS couple was determined from quasi reversible cyclic voltammograms at pH = 6.5 and found to be -380 mV...