C J Proctor

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi Modelling the role of the Hsp70/Hsp90 system in the maintenance of protein homeostasis
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 6:e22038. 2011
  2. ncbi Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration
    Carole J Proctor
    Center for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 5:e13175. 2010
  3. ncbi GSK3 and p53 - is there a link in Alzheimer's disease?
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Mol Neurodegener 5:7. 2010
  4. ncbi Explaining oscillations and variability in the p53-Mdm2 system
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    BMC Syst Biol 2:75. 2008
  5. ncbi An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
    Carole J Proctor
    School of Clinical and Medical Sciences Gerontology, Newcastle University, UK
    BMC Syst Biol 1:17. 2007
  6. ncbi Modelling the checkpoint response to telomere uncapping in budding yeast
    C J Proctor
    Institute for Ageing and Health, and School of Clinical Medical Sciences Gerontology, Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    J R Soc Interface 4:73-90. 2007
  7. ncbi Antipredator vigilance in birds: modelling the 'edge' effect
    Carole J Proctor
    Centre for Statistics and Stochastic Modelling, Department of Mathematics, University of Sussex, Falmer, Brighton BN1 9QH, UK
    Math Biosci 199:79-96. 2006
  8. ncbi Modelling the actions of chaperones and their role in ageing
    Carole J Proctor
    Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences Gerontology, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 126:119-31. 2005
  9. ncbi Modelling cellular senescence as a result of telomere state
    Carole J Proctor
    SCMS, Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Aging Cell 2:151-7. 2003
  10. ncbi Modelling antipredator vigilance and flight response in group foragers when warning signals are ambiguous
    C J Proctor
    Department of Gerontology, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    J Theor Biol 211:409-17. 2001

Detail Information

Publications18

  1. ncbi Modelling the role of the Hsp70/Hsp90 system in the maintenance of protein homeostasis
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 6:e22038. 2011
    ..The model can be used to assess specific interventions to reduce cell death due to impaired protein homeostasis...
  2. ncbi Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration
    Carole J Proctor
    Center for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 5:e13175. 2010
    ..Furthermore, our model provides a valuable tool, as it can be easily modified and extended to incorporate new experimental data, test hypotheses and make testable predictions...
  3. ncbi GSK3 and p53 - is there a link in Alzheimer's disease?
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Mol Neurodegener 5:7. 2010
    ..We propose that this interaction has an important contribution to cellular outcomes and to test this hypothesis we developed a stochastic simulation model...
  4. ncbi Explaining oscillations and variability in the p53-Mdm2 system
    Carole J Proctor
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    BMC Syst Biol 2:75. 2008
    ..The models can readily be modified as further information becomes available, and linked to other models of cellular ageing...
  5. ncbi An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
    Carole J Proctor
    School of Clinical and Medical Sciences Gerontology, Newcastle University, UK
    BMC Syst Biol 1:17. 2007
    ..The model can be used to predict the effects of different experimental procedures such as inhibition of the proteasome or shutting down the enzyme cascade responsible for ubiquitin conjugation...
  6. ncbi Modelling the checkpoint response to telomere uncapping in budding yeast
    C J Proctor
    Institute for Ageing and Health, and School of Clinical Medical Sciences Gerontology, Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    J R Soc Interface 4:73-90. 2007
    ..The model can be used to carry out a variety of in silico experiments in which different genes are knocked out and the results of simulation are compared to experimental data. Possible extensions to the model are also discussed...
  7. ncbi Antipredator vigilance in birds: modelling the 'edge' effect
    Carole J Proctor
    Centre for Statistics and Stochastic Modelling, Department of Mathematics, University of Sussex, Falmer, Brighton BN1 9QH, UK
    Math Biosci 199:79-96. 2006
    ....
  8. ncbi Modelling the actions of chaperones and their role in ageing
    Carole J Proctor
    Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences Gerontology, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 126:119-31. 2005
    ....
  9. ncbi Modelling cellular senescence as a result of telomere state
    Carole J Proctor
    SCMS, Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Aging Cell 2:151-7. 2003
    ..By letting the probability of uncapping depend upon telomere length, we show that the hypothesized model provides a good fit to experimental data...
  10. ncbi Modelling antipredator vigilance and flight response in group foragers when warning signals are ambiguous
    C J Proctor
    Department of Gerontology, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    J Theor Biol 211:409-17. 2001
    ....
  11. ncbi Modelling telomere shortening and the role of oxidative stress
    Carole J Proctor
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Mech Ageing Dev 123:351-63. 2002
    ..We suggest that theoretical models of this kind are valuable tools to bridge the gap between the verbal statements of hypotheses and their rigorous experimental test...
  12. ncbi A spatial model of antipredator vigilance
    C J Proctor
    Centre for Statistics and Stochastic Modelling, School of Mathematical Sciences, University of Sussex, Falmer, UK
    IMA J Math Appl Med Biol 17:75-93. 2000
    ..In particular the effect of each environmental parameter on this optimum is considered in turn. How the model can be adapted for different bird species is also investigated...
  13. ncbi Feedback between p21 and reactive oxygen production is necessary for cell senescence
    Joao F Passos
    Ageing Research Laboratories, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Syst Biol 6:347. 2010
    ..These ROS in turn replenish short-lived DNA damage foci and maintain an ongoing DDR. We show that this loop is both necessary and sufficient for the stability of growth arrest during the establishment of the senescent phenotype...
  14. ncbi A communication-based spatial model of antipredator vigilance
    Carole J Proctor
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Theor Biol 220:123-37. 2003
    ..The best strategy for the birds is found under a variety of environmental conditions, under the assumption that each individual acts selfishly to maximize its own fitness...
  15. ncbi Somatic mutations and ageing in silico
    Thomas B L Kirkwood
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Mech Ageing Dev 124:85-92. 2003
    ....
  16. ncbi Tools for the SBML Community
    Colin S Gillespie
    School of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioinformatics 22:628-9. 2006
    ..AVAILABILITY: All tools described are available from http://www.basis.ncl.ac.uk/software and are licensed under GNU General Public License...
  17. ncbi A mathematical model of ageing in yeast
    Colin S Gillespie
    Henry Wellcome Laboratory for Biogerontology Research, SCMS Gerontology, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Theor Biol 229:189-96. 2004
    ....
  18. ncbi Towards an e-biology of ageing: integrating theory and data
    Thomas B L Kirkwood
    Institute for Ageing and Heath, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Nat Rev Mol Cell Biol 4:243-9. 2003
    ..We describe how a new web-based modelling initiative is seeking to integrate data and hypotheses from diverse biological sources...