Research Topics
| Daniel H PalmerSummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirusTaha Elmetwali
Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, UK
Mol Cancer 9:52. 2010..The most profound induction of cell death in carcinoma cells is induced by membrane-bound rather than recombinant soluble CD40L, but like other TNF family ligands, it is cleaved from the membrane by matrix metalloproteinases...- A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinomaDaniel H Palmer
Cancer Research UK Clinical Trials Unit, CR UK Institute for Cancer Studies, Clinical Research Block
Hepatology 49:124-32. 2009..CONCLUSION: Autologous DC vaccination in patients with HCC is safe and well tolerated with evidence of antitumor efficacy assessed radiologically and serologically, with generation of antigen-specific immune responses in some cases... - Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancerDaniel H Palmer
Cancer Research UK Institute for Cancer Studies, Department of Pathology and Liver Research Laboratories, University of Birmingham, UK
J Clin Oncol 22:1546-52. 2004..The high level of nitroreductase expression observed at 1 to 5 x 10(11) virus particles mandates further studies in patients with inoperable tumors who will receive CTL102 and CB1954... - Gene- and immunotherapy for hepatocellular carcinomaDaniel H Palmer
CR UK Institute for Cancer Studies, Clinical Research Block, University of Birmingham, Birmingham, B15 2TT, UK
Expert Opin Biol Ther 5:507-23. 2005..The challenge remains to design clinical trials to optimally evaluate these agents and allow feedback to the laboratory for their ongoing development... - Cancer gene-therapy: clinical trialsDaniel H Palmer
CR UK Institute for Cancer Studies, University of Birmingham B15 2TT, UK
Trends Biotechnol 24:76-82. 2006..The challenge now is to translate these features into effective therapies that can supplement or supplant existing treatments... - CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signalsTaha Elmetwali
Cancer Research United Kingdom Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
J Immunol 184:1111-20. 2010..These data provide mechanistic insights into the consequences of CD40 activation in carcinoma cells and how these might be exploited in the clinical development of CD40-targeted anticancer therapies... - Endocrine therapy and other targeted therapies for metastatic breast cancerSyed A Hussain
Cancer Research UK, Institute for Cancer Studies and The Cancer Centre, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Expert Rev Anticancer Ther 4:1179-95. 2004..These include strategies to overcome endocrine resistance and methods to target deregulated endocrine and growth factor signaling pathways using gene and immunotherapy approaches... - Systemic therapies for hepatocellular carcinomaDaniel H Palmer
Cancer Research UK Institute for Cancer Studies, Clinical Research Block, University of Birmingham, Birmingham B15 2TA, UK
Expert Opin Investig Drugs 13:1555-68. 2004..At present there are a number of interesting therapeutic agents with potential activity in HCC. The challenge now is the design of clinical trials to optimally evaluate these agents... - Biology of testicular germ cell tumorsSyed A Hussain
Cancer Research UK Institute for Cancer Studies, University of Birmingham, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK
Expert Rev Anticancer Ther 8:1659-73. 2008..Current understanding of the role of genetic and epigenetic factors in the etiology of germ cell tumors and the biochemical mechanisms underlying chemotherapy sensitivity and resistance is discussed in detail in this review... - Carbonic anhydrase IX, a marker of hypoxia: correlation with clinical outcome in transitional cell carcinoma of the bladderSyed A Hussain
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Oncol Rep 11:1005-10. 2004..94). There was a trend towards longer survival for tumour expressing CA IX strongly. This is likely to be a reflection of the significantly higher rate of strong CA IX expression in non-invasive cancers influencing these survival data... - Clinical experience with adenovirus in cancer therapyDaniel H Palmer
CR UK Institute for Cancer Studies, The Medical School, University of Birmingham, Edgbaston, UK
Curr Opin Mol Ther 4:423-34. 2002..It is anticipated that adenovirus-mediated gene therapy will be integrated with existing treatment modalities, including surgery, chemotherapy and radiotherapy, to facilitate improvement in cancer treatments in the future...