Research Topics
Genomes and Genes | S OzanneSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes?S E Ozanne
Department of Clinical Biochemistry, Addenbrooke s Hospital, Level 4, Cambridge, UK
Diabetologia 49:2993-9. 2006..Previously we have shown that low birthweight is associated with changes in muscle insulin signalling proteins. Here we determined whether low birthweight is associated with changes in insulin signalling proteins in adipose tissue...- Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal studyClive J Petry
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
BMC Nephrol 7:14. 2006..This study monitored albuminuria longitudinally in male rats whose mothers had been protein restricted either during pregnancy or lactation... - Impaired PI 3-kinase activation in adipocytes from early growth-restricted male ratsS E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
Am J Physiol Endocrinol Metab 280:E534-9. 2001..These results demonstrate that reduced glucose tolerance observed in late adult life after early growth restriction is associated with adipocyte insulin resistance... - Poor fetal growth followed by rapid postnatal catch-up growth leads to premature deathSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
Mech Ageing Dev 126:852-4. 2005..This reduced maximum longevity was associated with early age-related weight loss. These results demonstrate that maternal nutrition during critical periods of development has a major impact on quantity as well as quality of life... - Lifespan: catch-up growth and obesity in male miceSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, UK
Nature 427:411-2. 2004.... - Early programming of weight gain in mice prevents the induction of obesity by a highly palatable dietSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, U K
Clin Sci (Lond) 106:141-5. 2004..These programmed responses are powerful enough to block excess weight gain from a highly palatable diet and, thus, have major implications for the drug-free regulation of food intake and obesity... - Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscleS E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, UK
J Endocrinol 177:235-41. 2003..These results suggest that maternal protein restriction leads to muscle insulin resistance. Reduced expression of PKC zeta may contribute to the mechanistic basis of this resistance... - Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expressionJane L Tarry-Adkins
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 293:R1259-66. 2007..These findings suggest that beneficial effects of slow growth during lactation are associated with increased antioxidant capacity and prevention of age-dependent telomere shortening in the kidney... - Long-term programming of blood pressure by maternal dietary iron restriction in the ratRohan M Lewis
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
Br J Nutr 88:283-90. 2002..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero... - Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevityJane L Tarry-Adkins
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Box 232, Hills Road, Cambridge, CB2 2QR, UK
Am J Physiol Renal Physiol 290:F509-16. 2006..Our findings indicate that a reduction in oxidative damage protection may be responsible for accelerated telomere shortening over time, resulting in increased cellular senescence, loss of renal function, and death in male rats... - Methods of cellular senescence induction using oxidative stressJian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Camgbridge, UK
Methods Mol Biol 371:179-89. 2007..Such induced premature senescent cells display many markers that are indistinguishable from replicative senescent cells. Thus, oxidative stress-induced senescent cells serve as an excellent in vitro tool for aging research... - Early programming of glucose-insulin metabolismSusan E Ozanne
Dept of Clinical Biochemistry, Level 4, Addenbrooke's Hospital, Hills Road, CB2 2QR, Cambridge, UK
Trends Endocrinol Metab 13:368-73. 2002.... - Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspringMalgorzata S Martin-Gronert
Department of Clinical Biochemistry, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 294:R494-500. 2008..MnSOD expression was increased in these animals. These data suggest that early nutrition can lead to alterations in insulin sensitivity and antioxidant capacity very early in life, which may influence life span... - The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspringRoselle L Cripps
Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK
Reprod Sci 15:448-56. 2008..These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance... - Fetal programming of glucose-insulin metabolismR Huw Jones
Institute of Metabolic Science, Metabolic Research Laboratories, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
Mol Cell Endocrinol 297:4-9. 2009..Fundamental underlying mechanisms are starting to emerge, including changes in the epigenotype and mitochondrial function... - Adverse effects of reduced oxygen tension on the proliferative capacity of rat kidney and insulin-secreting cell lines involve DNA damage and stress responsesJian Hua Chen
Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
Exp Cell Res 314:3075-80. 2008.... - Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespanJian Hua Chen
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
Clin Sci (Lond) 119:373-84. 2010.... - Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactationRoselle L Cripps
Metabolic Research Laboratories, Level 4, Institute of Metabolic Science, Box 289, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Clin Sci (Lond) 117:85-93. 2009..These results suggest that the early nutritional environment can affect the development of energy balance circuits and consequently obesity risk... - The relationship between poor growth rate and increased risk of Type 2 diabetes, insulin resistance and obesityRoselle L Cripps
Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QR, UK
Expert Rev Pharmacoecon Outcomes Res 6:79-86. 2006..Interventions both during pregnancy and early life as well as informed life choices in those at risk could dramatically reduce the huge clinical burden of obesity and its comorbidities... - Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in miceJian Hua Chen
University of Cambridge Metabolic Research Laboratories Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
PLoS ONE 4:e4950. 2009..These observations suggest that maternal protein restriction can affect major metabolic pathways implicated in regulation of lifespan at a young age which may explain the impact of maternal diet on longevity... - Early-life nutrition influences thymic growth in male mice that may be related to the regulation of longevityJian Hua Chen
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, U K
Clin Sci (Lond) 118:429-38. 2010..In conclusion, differential thymic growth may contribute to the regulation of longevity by maternal diet... - Early life nutrition and metabolic programmingDenise S Fernandez-Twinn
Department of Clinical Biochemistry, University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Sciences, Addenbrooke s Hospital, Cambridge, United Kingdom
Ann N Y Acad Sci 1212:78-96. 2010..It will also discuss evidence for the proposed molecular mechanisms and the potential for intervention... - Mechanisms of disease: the developmental origins of disease and the role of the epigenotypeSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Level 4, Addenbrooke s Hospital, Cambridge, UK
Nat Clin Pract Endocrinol Metab 3:539-46. 2007..Environmentally induced changes in the epigenotype might be key primary events in the developmental origins of disease, with important clinical implications... - DNA damage, cellular senescence and organismal ageing: causal or correlative?Jian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
Nucleic Acids Res 35:7417-28. 2007..Here we review the recent advances in addressing the role of DNA damage in cellular senescence and organismal ageing... - Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblastsJian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, United Kingdom
J Biol Chem 279:49439-46. 2004..Our data suggest that loss of proliferative capacity in oxidatively stressed cells is a multistep process regulated by time-dependent molecular events that may play differential roles in induction and maintenance of cellular senescence... - Fetal and perinatal programming of appetiteRoselle L Cripps
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
Clin Sci (Lond) 109:1-11. 2005..The outcome of these and future studies could prove clinically crucial, particularly in the debate over the benefits of breast feeding, which provides a lower plane of nutrition compared with formula feeding... - Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycleJian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital Level 4, Hills Road, Cambridge CB2 2QR, UK
DNA Repair (Amst) 4:1140-8. 2005..Oxidative stress encountered by cells in S-phase resulted in more persistent DNA damage, more permanent cell cycle arrest and the induction of premature senescence... - Analysis of expression of growth factor receptors in replicatively and oxidatively senescent human fibroblastsJian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Level 4, Hills Road, Cambridge CB2 2QR, United Kingdom
FEBS Lett 579:6388-94. 2005..This suggests that mechanisms underlying diminished responsiveness to mitogens might be different in replicative senescence and oxidatively premature senescence... - Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspringDenise S Fernandez-Twinn
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 291:R429-36. 2006..012). LP offspring have reduced beta-adrenergic responsiveness and attenuated adrenergic and insulin signaling, suggesting that intrauterine undernutrition alters heart failure risk... - Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stressJian Hua Chen
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, United Kingdom
FEBS Lett 580:6669-73. 2006..These findings suggest that cellular senescence is not a static process hence care must be taken in the selection of biomarkers of senescence in studies of ageing... - Pre- and early postnatal nongenetic determinants of type 2 diabetesSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QR, UK
Expert Rev Mol Med 4:1-14. 2002..Changes in gene expression include those concerned with hormone receptors, signalling and glycolytic enzymes. Many important questions remain for future research... - Developmental programming of energy balance and the metabolic syndromeElizabeth C Cottrell
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
Proc Nutr Soc 66:198-206. 2007..The development of central appetite and expenditure circuits and of peripheral metabolic tissues, are likely to play a key role in the long-term regulation of energy balance... - Programming of appetite and type 2 diabetesMalgorzata S Martin-Gronert
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QR, UK
Early Hum Dev 81:981-8. 2005..Molecular mechanisms involved might include epigenetic alteration of the fetal genome in response to maternal nutrition... - Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later lifeJane L Tarry-Adkins
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke s Treatment Centre, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 OQQ, UK
FASEB J 24:2762-71. 2010..These findings provide mechanisms by which suboptimal early nutrition can lead to T2D development later in life... - Fetal growth and adult diseasesSusan E Ozanne
Department of Clinical Biochemistry, University of Cambridge
Semin Perinatol 28:81-7. 2004..Once this is clear, there will be a major opportunity for disease prevention... - Postnatal development of hypothalamic leptin receptorsElizabeth C Cottrell
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Vitam Horm 82:201-17. 2010..Exactly how leptin exerts these effects remains unknown, but changes in the distribution of hypothalamic leptin receptors during this period may, at least in part, underlie these age-specific effects of leptin... - Mechanisms involved in the developmental programming of adulthood diseaseMatthew J Warner
Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, UK
Biochem J 427:333-47. 2010.... - Intra-uterine origins of type 2 diabetesR Huw Jones
Department of Clinical Biochemistry, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
Arch Physiol Biochem 113:25-9. 2007.... - Mechanisms linking suboptimal early nutrition and increased risk of type 2 diabetes and obesityMalgorzata S Martin-Gronert
Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Nutr 140:662-6. 2010..The fundamental mechanisms by which these programmed changes occur remain to be fully defined but are thought to involve epigenetic mechanisms... - Altered body composition and metabolism in the male offspring of high fat-fed ratsAlexandra J Buckley
School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
Metabolism 54:500-7. 2005..A maternal diet high in omega-6 polyunsaturated fat evokes programming within the metabolic processes of the offspring that may predispose the offspring to the development of metabolic diseases... - Fetal determinants of type 2 diabetesBrigitte Reusens
Laboratoire de Biologie Cellulaire, Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
Curr Drug Targets 8:935-41. 2007..Possible underlying mechanisms are discussed and evidence for potential early intervention strategies are reported... - Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programmingAnne Maj Samuelsson
Division of Reproduction and Endocrinology, King s College London, London, UK
Hypertension 51:383-92. 2008..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role...
Research Grants
- Programming of gene expression during fetal lifeS Ozanne; Fiscal Year: 2005....