Research Topics
Genomes and Genes | Kevin M O'shaughnessySummaryAffiliation: University of Cambridge Country: UK Publications
| Collaborators
|
Detail Information
Publications
Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohortK M O'Shaughnessy
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge Clinical School, Cambridge, UK
Hypertension 33:1338-41. 1999..T677 homozygotes for methylenetetrahydrofolate reductase were 11% and 11.5% in the 2 groups, respectively. We conclude that there is no evidence of association of preeclampsia with either of these 2 polymorphisms in our study population...- Role of diet in hypertension managementKevin M O'shaughnessy
Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, Cambridge, CB2 QQ, UK
Curr Hypertens Rep 8:292-7. 2006..Nevertheless, the message to patients must be that dietary changes made within a concerted alteration in lifestyle can have a very significant impact on their blood pressure... - HapMap, pharmacogenomics, and the goal of personalized prescribingKevin M O'shaughnessy
Clinical Pharmacology Unit, University of Cambridge, Cambridge, UK
Br J Clin Pharmacol 61:783-6. 2006..The provision of the human genomic sequence and now data from the HapMap project look set to bring 'personalized prescription' a step closer... - The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjectsK M O'Shaughnessy
Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, UK
Clin Sci (Lond) 99:233-8. 2000.... - The genetics of essential hypertensionK M O'Shaughnessy
Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge, England
Br J Clin Pharmacol 51:5-11. 2001..This knowledge will irrevocably change the way we approach this disease in terms of its diagnosis, risk assessment for end-points such as stroke and heart disease, and the customised treatment that might be offered in the future... - Dissecting complex traits: recent advances in hypertension genomicsKevin M O'shaughnessy
Clinical Pharmacology Unit, Department of Medicine, Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Genome Med 1:43. 2009..The results of these are expected in the near future and may finally deliver the long-awaited goal of personalized drug therapy for hypertensive patients... - Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involvedAmir P Golbang
Department of Medicine, University of Cambridge, UK
Am J Physiol Renal Physiol 291:F1369-76. 2006..These results further highlight important differences in the mechanism by which WNK kinases affect expression of NCCT vs. other membrane proteins such as ROMK... - Renal and brain isoforms of WNK3 have opposite effects on NCCT expressionMark Glover
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
J Am Soc Nephrol 20:1314-22. 2009..Taken together, these results suggest that the C-terminal motifs contributed by exons 18 and 22 play an important role in the actions of WNK3 isoforms on NCCT... - The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4Mark Glover
Department of Medicine, University of Cambridge, UK
Can J Physiol Pharmacol 88:986-95. 2010..In the mouse kidney, PP4 is selectively expressed in the distal nephron, including cells of the distal convoluted tubule cells, suggesting that PP4 may have a physiological role in regulating NCC and hence NaCl reabsorption in vivo... - Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals- Yasmin
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Box 110, Cambridge CB2 2QQ, UK
Arterioscler Thromb Vasc Biol 26:1799-805. 2006..Therefore, we investigated the influence of known MMP-9 (-1562C>T, R279Q) polymorphisms on arterial stiffness in a large cohort of healthy individuals (n=865)... - The acidic motif of WNK4 is crucial for its interaction with the K channel ROMKMeena Murthy
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Cambridge CB22QQ, UK
Biochem Biophys Res Commun 375:651-4. 2008..These results confirm the important role of the acidic motif of WNK4 in its protein-protein interaction with the ROMK channel... - Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomasElena A B Azizan
Clinical Pharmacology Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Hypertension 59:587-91. 2012..Hence, somatic KCNJ5 mutations are not restricted to large APAs (>2 cm), and their frequency in our unselected series suggests they are common and could be important in the molecular pathogenesis of many sporadic cases of APA... - Role of SPAK and OSR1 signalling in the regulation of NaCl cotransportersAnnie Mercier-Zuber
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, and Clinical Pharmacology Unit, Addenbrooke s Hospital, Cambridge, UK
Curr Opin Nephrol Hypertens 20:534-40. 2011..This review gives an overview of the actions of SPAK and OSR1 kinases on NaCl cotransporters and highlights their possible therapeutic potential... - SPAK and WNK kinases: a new target for blood pressure treatment?Mark Glover
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, UK
Curr Opin Nephrol Hypertens 20:16-22. 2011..The aim of this review is to provide an overview of the recent developments in the regulation of NCC, highlighting a potential new therapeutic target for the treatment of hypertension... - Expression of the epithelial Na(+) channel and other components of an aldosterone response pathway in human adrenocortical cellsTimothy J Burton
Clinical Pharmacology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Eur J Pharmacol 613:176-81. 2009..Studies in H295R cells, however, suggest that ENaC is not an important mediator of (22)Na-uptake or aldosterone production. Further studies are required to determine the importance of an adrenal aldosterone response pathway... - Genetics of arterial structure and function: towards new biomarkers for aortic stiffness?- Yasmin
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Clin Sci (Lond) 114:661-77. 2008.... - Hypertension, dietary salt intake, and the role of the thiazide-sensitive sodium chloride transporter NCCTMark Glover
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, UK
Cardiovasc Ther 29:68-76. 2011..It also exemplifies how data coming from the rare monogenic hypertension syndromes can together with genome-wide association studies in hypertension deliver novel druggable targets... - Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretionTanja Brenner
Department of Medicine, University of Cambridge, Cambridge, UK
Am J Physiol Endocrinol Metab 295:E1480-6. 2008..This suggests that human adrenal glomerulosa cells may utilize both of these K2P channels for their background potassium current... - WNK1 affects surface expression of the ROMK potassium channel independent of WNK4Georgina Cope
Department of Medicine, University of Cambridge, Cambridge, UK
J Am Soc Nephrol 17:1867-74. 2006..Together, these findings emphasize that the molecular mechanisms that underpin WNK1 regulation of ROMK expression are distinct from those that affect NCCT expression... - Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals- Yasmin
Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Hypertens 24:499-502. 2006..The aim of this study was to investigate the possible influence of the common FBN-1 genotypes on arterial stiffness in a large cohort of healthy individuals... - A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190Mark Glover
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge, Cambridge, UK
Open Med Chem J 4:57-61. 2010..Using an approach similar to that used in p38 and ERK, we show that a single substitution in WNK4 (T261G) dramatically enhances its susceptibility to the inhibitors SB 202190 and SB 203580...