Research Topics
Species | L L NgSummaryAffiliation: University of Leicester Country: UK Publications
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Detail Information
Publications
Biomarkers in acute myocardial infarctionDaniel Chan
Leicester National Institute for Health Research Cardiovascular Biomedical Research Unit, UK
BMC Med 8:34. 2010..Randomised trials are urgently needed to address this translational gap before the use of novel biomarkers becomes common practice to facilitate tailored treatment following an acute coronary event...- Plasma urotensin in human systolic heart failureLeong L Ng
Department of Medicine and Therapeutics, University of Leicester, Leicester, UK
Circulation 106:2877-80. 2002..We investigated plasma UTN levels in heart failure (HF; left ventricular systolic dysfunction) in comparison with plasma N-terminal pro-brain natriuretic peptide (N-BNP) levels... - Diagnosis of heart failure using urinary natriuretic peptidesL L Ng
University of Leicester, Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, U K
Clin Sci (Lond) 106:129-33. 2004..Use of urinary N-BNP for heart failure diagnosis may be suitable for high-throughput screening, especially in subjects reluctant to provide blood samples... - Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stressRichard K M Wong
Division of Medicine and Therapeutics, University of Leicester, Leicester, U K
Diabetes 51:2846-53. 2002.... - Plasma urocortin in human systolic heart failureLeong L Ng
University of Leicester Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, U K
Clin Sci (Lond) 106:383-8. 2004..Its decline with increasing HF severity may expedite disease progression due to diminished cardioprotective/anti-inflammatory effects. UCN measurement may also complement N-BNP in the diagnosis of early HF... - Identification of previously undiagnosed left ventricular systolic dysfunction: community screening using natriuretic peptides and electrocardiographyLeong L Ng
Department of Medicine and Therapeutics, Robert Kilpatrick, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Heart Fail 5:775-82. 2003..We examined strategies to improve the positive predictive value of natriuretic peptides in screening for undiagnosed left ventricular systolic dysfunction (LVSD) in the community... - Community screening for left ventricular systolic dysfunction using plasma and urinary natriuretic peptidesLeong L Ng
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
J Am Coll Cardiol 45:1043-50. 2005..We sought to compare urinary and plasma N-terminal pro-brain natriuretic peptide (N-BNP) in left ventricular systolic dysfunction (LVSD) diagnosis... - Myeloperoxidase and C-reactive protein augment the specificity of B-type natriuretic peptide in community screening for systolic heart failureLeong L Ng
Department of Cardiovascular Sciences, University of Leicester, UK
Am Heart J 152:94-101. 2006..We sought to improve specificity using inflammatory markers such as C-reactive protein (CRP) and myeloperoxidase (MPO), which have been implicated in cardiovascular disease... - Oxygen-regulated protein 150 and prognosis following myocardial infarctionLeong L Ng
Pharmacology and Therapeutics Group, Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
Clin Sci (Lond) 112:477-84. 2007..In conclusion, ORP150 and peptide fragments derived from it are secreted following AMI and provide independent prognostic information on mortality. High levels associated with endoplasmic reticulum/hypoxic stress predict a poor outcome... - Proteinase 3 and prognosis of patients with acute myocardial infarctionLeong L Ng
Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK
Clin Sci (Lond) 120:231-8. 2011..PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy... - Red cell Na+/Li+ countertransport and Na+/H+ exchanger isoforms in human proximal tubulesL L Ng
Department of Medicine, Leicester Royal Infirmary, England, United Kingdom
Kidney Int 58:229-35. 2000.... - Na+/H+ exchanger activity and phosphorylation in temperature-sensitive immortalized proximal tubule cell lines derived from the spontaneously hypertensive ratL L Ng
Department of Medicine and Therapeutics, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, U K
Clin Sci (Lond) 98:409-18. 2000..These cell lines form a useful model for defining the biochemical mechanisms leading to the NHE-1 phenotype in the SHR kidney, in addition to investigations of other SHR phenotypic markers... - Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failureLeong L Ng
Department of Medicine and Therapeutics, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, U K
Clin Sci (Lond) 102:411-6. 2002.... - Cardiotrophin-1 predicts death or heart failure following acute myocardial infarctionSohail Q Khan
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
J Card Fail 12:635-40. 2006..84 (95% CI: 0.78-0.91, P < .001). CONCLUSION: After an AMI, combined levels of CT-1 and NT-proBNP are more informative at predicting death or heart failure than either marker alone... - C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) studySohail Q Khan
University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Circulation 115:2103-10. 2007..We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic peptide (NTproBNP), after acute myocardial infarction... - Prolonged stability of endogenous cardiotrophin-1 in whole bloodP F Downie
Department of Medicine and Therapeutics, University of Leicester, UK
Metabolism 50:237-40. 2001.... - Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosisS Talwar
Department of Medicine and Therapeutics, University of Leicester, Leicester, UK
Eur J Heart Fail 3:15-9. 2001..These markers may also be useful to identify the optimum time for surgery in AS... - Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunctionIain B Squire
Department of Medicine and Therapeutics, University of Leicester, Leicester, United Kingdom
J Card Fail 10:328-33. 2004..Higher left ventricular volumes are associated with lower plasma MMP-2 concentrations. Circulating MMP concentrations may provide insights into left ventricular remodeling after acute myocardial infarction... - Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndromeOnkar S Dhillon
Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Clin Sci (Lond) 118:249-57. 2010.... - N-terminal pro-B-type natriuretic peptide is better than TIMI risk score at predicting death after acute myocardial infarctionS Q Khan
University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, UK
Heart 94:40-3. 2008..N-terminal pro-B-type natriuretic peptide (NTproBNP) has also been found to be useful in predicting mortality following STEMI... - Leucocyte intracellular pH and Na+/H+ exchanger isoform-1 activity in postpartum women with pre-eclampsiaV M Lee
Department of Medicine and Therapeutics, Leicester Royal Infirmary, UK
BJOG 108:615-22. 2001..This increased activity is not due to an increase in exchanger isoform-1 protein abundance or the presence of exchanger isoform-3... - Pre-discharge, but not admission, levels of NT-proBNP predict adverse prognosis following acute LVFIain B Squire
Department of Medicine and Therapeutics, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, LE2 7LX, Leicester, UK
Eur J Heart Fail 5:499-506. 2003..79 cf 0.66), LVF hospitalisation (0.78 cf 0.70) or heart failure as an outpatient (0.71 cf 0.61). CONCLUSIONS: Plasma NT-proBNP measured pre-discharge provides useful prognostic information following hospitalisation with acute LVF... - Neutrophil activation and production of reactive oxygen species in pre-eclampsiaVirginia M Lee
University of Leicester, The Division of Medicien and Therapeutics, Leicester Royal Infirmary, UK
J Hypertens 21:395-402. 2003..Increased ROS production in pre-eclampsia may highlight a role for neutrophils in the oxidative stress and associated endothelial dysfunction that are characteristic of the condition... - Reference ranges for natriuretic peptides for diagnostic use are dependent on age, gender and heart rateIan Loke
Department of Medicine and Therapeutics, Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Heart Fail 5:599-606. 2003..In constructing normal ranges for diagnostic use, covariates such as age and gender must be considered, in addition to the format of assay being used... - Plasma natriuretic peptides up to 2 years after acute myocardial infarction and relation to prognosis: an OPTIMAAL substudyIain B Squire
University of Leicester Department of Cardiovascular Sciences, Leicester, United Kingdom
J Card Fail 11:492-7. 2005..026) had independent predictive value for death after 30 days. CONCLUSION: N-ANP, BNP, N-BNP, and CNP show distinct plasma profiles after AMI. Failure of plasma N-BNP to fall in the 30 days after AMI indicates adverse prognosis... - Potassium and activity of the sodium hydrogen exchanger isoform 1 in vascular smooth muscle of hypertensive ratsP A Quinn
Department of Medicine and Therapeutics, University of Leicester, Leicester, UK
Metabolism 50:778-82. 2001..This response of NHE-1 in SHR VSMCs to K(+) depletion indicated a direct effect on these cells and could potentially enhance the contractile or proliferative phenotype of these cells in vivo... - Plasma cardiotrophin-1 following acute myocardial infarction: relationship with left ventricular systolic dysfunctionSuneel Talwar
Department of Medicine and Therapeutics, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, U.K
Clin Sci (Lond) 102:9-14. 2002..CT-1 measured soon after AMI is indicative of LV dysfunction, and this cytokine may have a role in the development of ventricular remodelling and heart failure after AMI... - Stimulated mitogen-activated protein kinase is necessary but not sufficient for the mitogenic response to angiotensin II. A role for phospholipase DN Wilkie
Department of Cell Physiology and Pharmacology, University of Leicester, Medical Sciences Building, P O Box 138, University Road, Leicester LE1 9HN, United Kingdom
J Biol Chem 271:32447-53. 1996.... - Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signalingToryn M Poolman
Pharmacology and Therapeutics Group, Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, UK
Free Radic Biol Med 39:118-32. 2005..Other known inhibitors of both PI3K and Akt were also found to inhibit this response. Therefore, inhibition of signaling through the PI3K to NADPH oxidase by t-RVT might represent an important anti-inflammatory mechanism... - Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) studySohail Q Khan
University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, United Kingdom
J Am Coll Cardiol 49:1525-32. 2007..This study sought to assess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial infarction (AMI)... - Myotrophin is a more powerful predictor of major adverse cardiac events following acute coronary syndrome than N-terminal pro-B-type natriuretic peptideSohail Q Khan
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Clin Sci (Lond) 112:251-6. 2007..63; P=0.006). In conclusion, after an ACS, levels of myotrophin are more informative at predicting MACE than NTproBNP and may be useful to risk stratify patients... - Urotensin II is raised in acute myocardial infarction and low levels predict risk of adverse clinical outcome in humansSohail Q Khan
University of Leicester, Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Int J Cardiol 117:323-8. 2007..We also compared UII to N terminal pro B type natriuretic peptide (NT-BNP) to evaluate whether levels of UII can be used to predict the risk of adverse clinical outcome (ACO)... - Improving the diagnostic accuracy of N-terminal B-type natriuretic peptide in human systolic heart failure by plasma profiling using mass spectrometryDonald J L Jones
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, UK
J Proteome Res 6:3329-34. 2007..The accuracy of SHF diagnosis using NTproBNP is improved by the use of a plasma profile of 6 peptide peaks, reducing the uncertainty in the diagnostic gray zone of using NTproBNP alone... - Natriuretic peptides in common valvular heart diseaseChristopher D Steadman
Department of Cardiovascular Sciences, University Hospitals of Leicester, Leicester, UK
J Am Coll Cardiol 55:2034-48. 2010.... - N-terminal pro-B-type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndromeSohail Q Khan
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Clin Sci (Lond) 117:31-9. 2009..85] and 6-month mortality (AUC, 0.81). NT-proBNP gives complementary information to the GRACE risk score for predicting early and late mortality. The inclusion of the NT-proBNP blood test is useful in risk-stratifying patients after ACS... - Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic AcidRichard K M Wong
Division of Medicine and Therapeutics, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Circulation 108:1858-64. 2003..AA is generated by cPLA2, which may be stimulated through an AGE-activated redox-sensitive pathway... - Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarctionDominic Kelly
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Am J Cardiol 106:477-82. 2010..001 for all comparisons, log-rank test). In conclusion, higher plasma TIMP-1, -2, and -4 after AMI are associated with MACEs and provide additional prognostic information to that obtained from GRACE clinical risk scores alone... - Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarctionSohail Q Khan
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur Heart J 30:1057-65. 2009..We were interested to see if GDF-15 could provide long-term prognostic value in post-AMI patients. We compared GDF-15 with N-terminal pro-B-type natriuretic peptide (NT-proBNP)... - Plasma N-terminal B-Type natriuretic peptide as an indicator of long-term survival after acute myocardial infarction: comparison with plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) studySohail Q Khan
University of Leicester, Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom
J Am Coll Cardiol 51:1857-64. 2008..Our aim was to assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients after acute myocardial infarction (AMI)... - N-terminal pro-atrial natriuretic peptide (N-ANP) and N-terminal pro-B-type natriuretic peptide (N-BNP) in the prediction of death and heart failure in unselected patients following acute myocardial infarctionIain B Squire
Department of Medicine and Therapeutics, University of Leicester, Leicester Royal Infirmary, LE2 7LX, UK
Clin Sci (Lond) 107:309-16. 2004..Our results indicate that N-BNP predicts 30-day and N-ANP >30-day mortality. We conclude that consideration of both N-ANP and N-BNP identifies a greater number of patients at risk of death or heart failure than either peptide alone... - C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) StudySohail Q Khan
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Am Heart J 154:736-42. 2007..We investigated the cardiovascular prognostic value post-AMI of CT-proET-1 and compared it to N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF... - Prognostic value of mid-regional pro-adrenomedullin levels taken on admission and discharge in non-ST-elevation myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) II studyOnkar S Dhillon
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
J Am Coll Cardiol 56:125-33. 2010..N-terminal pro-B-type natriuretic peptide and GRACE (Global Registry of Acute Coronary Events) score were used as comparators... - Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarctionSohail Q Khan
Department of Cardiovascular Medicine, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
Heart 93:826-31. 2007..One such inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of death or MI in patients with ST segment elevation myocardial infarction (STEMI) is unclear... - Influence of confounding factors on plasma mid-regional pro-adrenomedullin and mid-regional pro-A-type natriuretic peptide concentrations in healthy individualsSanjay S Bhandari
Department of Cardiovascular Sciences, University of Leicester and NIHR Cardiovascular Biomedical Research Unit, Leicester, UK
Biomarkers 16:281-7. 2011..MRproADM and MRproANP can be used as diagnostic and prognostic markers in heart failure... - Cardiotrophin-1 protects the human myocardium from ischemic injury. Comparison with the first and second window of protection by ischemic preconditioningS Ghosh
Division of Cardiac Surgery, Department of Surgery, University of Leicester, Glenfield Hospital, LE3 9QP, Leicester, UK
Cardiovasc Res 48:440-7. 2000..We investigated the cardioprotective effects of CT-1 on the human myocardium and compared this benefit with the early and delayed protection afforded by ischemic preconditioning (PC)... - Altered Na+/H+ exchanger isoform 1 activity in immortalized lymphoblasts from women with pre-eclampsia: evidence for an intermediate phenotypeV M Lee
University of Leicester, Division of Medicine and Therapeutics, Level 4, Clinical Sciences Building, Leicester Royal Infirmary, UK
Clin Sci (Lond) 103:503-9. 2002..Overactivity of the Na(+)/H(+) exchanger may contribute to the raised intracellular Na(+) concentration reported previously in white blood cells from women with pre-eclampsia... - Myotrophin in human heart failureIan Loke
Department of Medicine and Therapeutics, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
J Am Coll Cardiol 42:719-25. 2003..This response is attenuated in more severe disease. The contribution of myotrophin to NFkappaB-mediated gene transcription and preservation of cardiac muscle mass remains to be investigated further... - Procalcitonin as a prognostic marker in patients with acute myocardial infarctionDominic Kelly
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
Biomarkers 15:325-31. 2010..Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions... - Brain naturetic peptide (BNP) and diabetes mellitusL L Ng
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Diabet Med 21:8-10. 2004 - Circulating stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarctionD Kelly
Department of Cardiovascular Sciences, University of Leicester, UK
Eur J Heart Fail 10:133-9. 2008..We investigated the temporal profile of MMP-3 and its relationship to LV dysfunction and prognosis following AMI... - Does cigarette smoking increase plasma urotensin II concentrations?S J Gold
University Department of Cardiovascular Sciences, Pharmacology and Therapeutics Group, Division of Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
Eur J Clin Pharmacol 63:253-7. 2007..Our secondary aim was to compare the results obtained from assaying simultaneously using both radioimmunoassay (RIA) and immunoluminometric assay (ILMA)... - Desensitisation of native and recombinant human urotensin-II receptorsMadura S Batuwangala
Division of Anaesthesia, Critical Care and Pain Management, University Department of Cardiovascular Sciences Pharmacology and Therapeutics Group, University of Leicester, Leicester, LE1 5WW, UK
Naunyn Schmiedebergs Arch Pharmacol 380:451-7. 2009..In summary, we report differences in the desensitisation profiles of native and recombinant U-II receptors. Design and interpretation of functional experiments are hampered by irreversibility of U-II binding... - NADPH oxidase activity in preeclampsia with immortalized lymphoblasts used as modelsVirginia M Lee
University of Leicester, Division of Medicine and Therapeutics, Level 4, Clinical Sciences Bldg, Leicester Royal Infirmary, Leicester, England
Hypertension 41:925-31. 2003..The enhancement of reactive oxygen species generation may be important in mediating the endothelial dysfunction seen in preeclampsia... - C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarctionDominic Kelly
Department of Cardiovascular Sciences, University of Leicester, UK
J Card Fail 14:739-45. 2008..The aim of this study was to describe the association between Copeptin with LV dysfunction, volumes, and remodeling and clinical heart failure post-AMI... - Gender and renal function influence plasma levels of copeptin in healthy individualsSanjay S Bhandari
Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, U K
Clin Sci (Lond) 116:257-63. 2009..The present study suggests that gender and renal function specific partition values should be used to interpret copeptin values in future studies of this biomarker in HF or ischaemic heart disease... - Searching for biomarkers of heart failure in the mass spectra of blood plasmaRichard Willingale
Department of Physics and Astronomy, University of Leicester, Leicester, UK
Proteomics 6:5903-14. 2006..Finally, a test dataset comprising a further 32 HF patients and 20 controls was used to verify that the 18 putative biomarkers and classification algorithms gave reliable predictions (accuracy 88.5%, ROC score 0.998)... - The midregional portion of proadrenomedullin is an independent predictor of left ventricular mass index in hypertensionSanjay S Bhandari
Departmet of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, United Kingdom
Metabolism 59:7-13. 2010..Patients who test positive would necessitate echocardiography, enabling better resource allocation... - Acute management of pregnancy associated cardiomyopathy with cardiac resynchronisation therapyDominic Kelly
Department of Cardiology, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, United Kingdom
Eur J Heart Fail 9:542-4. 2007 - A rat brain atlas of urotensin-II receptor expression and a review of central urotensin-II effectsBenjamin D Hunt
University Department of Cardiovascular Sciences Pharmacology and Therapeutics Group, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Naunyn Schmiedebergs Arch Pharmacol 382:1-31. 2010..These predicted responses lend themselves to relatively simple experimental verification... - Activation of a novel natriuretic endocrine system in humans with heart failureHafid Narayan
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, LeicesterLE2 7LX, UK
Clin Sci (Lond) 118:367-74. 2010..Elevated plasma proguanylin and prouroguanylin levels are associated with hypertension, renal impairment and increasing severity of HF. This novel endocrine system may contribute to the pathophysiology of HF... - Cardiotropin-1 and myocardial strain change heterogeneously in cardiomyopathyD Dean Potter
Division of Cardiovascular Surgery, University of Leicester, Leicester, United Kingdom
J Surg Res 141:277-83. 2007..The purpose of this study was to measure regional changes in cardiotrophin-1 (CT-1), a cytokine thought to play a role in LV remodeling, and regional changes in LV strain as measured with magnetic resonance imaging... - Measurement of calcium and movement in heart cellsLeong L Ng
Department of Cardiovascular Diseases, Leicester Royal Infirmary, University of Leicester, UK
Methods Mol Biol 312:261-8. 2006 - Neutrophil intracellular pH and Na+/H+ exchanger activity in pre-eclampsiaVirginia M Lee
Department of Medicine, Leicester Royal Infirmary, Leicester, UK
Metabolism 52:87-93. 2003..Intracellular pH may have been affected by plasma as shown in the time course experiments. DLF, an inhibitor of Na(+)/K(+)ATPase, may contribute to this intracellular acidosis in pre-eclamptic neutrophils... - Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundanceOliver Zolk
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
Circulation 106:1442-6. 2002..Although cardiac CT-1 gene expression is known to be upregulated in some animal models of congestive heart failure, the activation state of the CT-1 system in patients with congestive heart failure is unknown... - Is plasma N-BNP a good indicator of the functional reserve of failing hearts? The FRESH-BNP studySimon G Williams
Academic Unit of Molecular Vascular Medicine, University of Leeds, Martin Wing, Leeds General Infirmary, Leeds LS1 3EX, UK
Eur J Heart Fail 6:891-900. 2004.... - Comparison of plasma N-brain natriuretic peptide, peak oxygen consumption, and left ventricular ejection fraction for severity of chronic heart failureSimon G Williams
Academic Unit of Molecular Vascular Medicine, University of Leeds, Leeds General Infirmary, Leeds, United Kingdom
Am J Cardiol 93:1560-1. 2004..001) and exercise duration (p = 0.001), whereas LVEF showed very poor correlations with peak VO(2) and exercise duration (both p >0.3). The results suggest that N-BNP actually reflects functional cardiac impairment better than LVEF... - Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort studyDominic Kelly
Department of Vascular Surgery, St George s Hospital Medical School, London, UK
Eur Heart J 28:711-8. 2007.... - N-terminal Pro-B-type natriuretic peptide, vascular disease risk, and cholesterol reduction among 20,536 patients in the MRC/BHF heart protection studyJonathan R Emberson
Clinical Trial Service Unit, University of Oxford, UK
J Am Coll Cardiol 49:311-9. 2007..We sought to assess the ability of N-terminal pro-B-type natriuretic peptide (N-BNP) to predict vascular events in high-risk people and to test whether statins benefit people with high levels of N-BNP... - Exercise duration and peak systolic blood pressure are predictive of mortality in ambulatory patients with mild-moderate chronic heart failureSimon G Williams
Cardiac Transplant Unit, Wythenshawe Hospital, Manchester, UK
Cardiology 104:221-6. 2005..We sought to investigate whether exercise and haemodynamic parameters lack independent prognostic value in a cohort of unselected ambulatory patients with mild-moderate CHF... - The cardioprotective agent urocortin induces expression of CT-1Sadia Janjua
Institute of Child Health, University College London, London WC1N 1 EH, UK
Cardiovasc Toxicol 3:255-62. 2003..Hence, a specific cardioprotective factor can induce enhanced expression of another cardioprotective factor belonging to an unrelated protein family... - Left atrial radiofrequency ablation during mitral valve surgery for continuous atrial fibrillation: a randomized controlled trialGeorge Doukas
Department of Cardiac Surgery, Glenfield Hospital, University Hospitals of Leicester NHS Trust, England
JAMA 294:2323-9. 2005.... - Increased free radical production in hypertension due to increased expression of the NADPH oxidase subunit p22(phox) in lymphoblast cell linesAndrew I Pettit
Royal United Hospital Bath, Bath, UK
J Hypertens 20:677-83. 2002..To confirm increased production of reactive oxygen species (ROS) in hypertension, to demonstrate the source of ROS and to analyse NADPH oxidase subcomponent expression in hypertension... - Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) studyMartin R Wilkins
Experimental Medicine and Toxicology, Imperial College London, W12 0NN, UK
Am J Respir Crit Care Med 171:1292-7. 2005..Phosphodiesterase type 5 (PDE5) inhibition has been proposed for the treatment for pulmonary arterial hypertension (PAH)...