Elisabeth P Nacheva

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Deletions adjacent to BCR and ABL1 breakpoints occur in a substantial minority of chronic myeloid leukemia patients with masked Philadelphia rearrangements
    Valeria A S De Melo
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Cancer Genet Cytogenet 182:111-5. 2008
  2. ncbi FISH mapping of Philadelphia negative BCR/ABL1 positive CML
    Anna Virgili
    Molecular Cytogenetics, Academic Haematology, Royal Free and UCL Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Mol Cytogenet 1:14. 2008
  3. ncbi Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines
    Anna Virgili
    Academic Haematology, University College London Cancer Institute, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Mol Cytogenet 3:15. 2010
  4. ncbi Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia
    Elisabeth P Nacheva
    UCL School of Medicine, Cancer Institute, Academic Haematology, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK
    BMC Genomics 11:41. 2010
  5. ncbi Human herpesvirus 6 integrates within telomeric regions as evidenced by five different chromosomal sites
    Elisabeth P Nacheva
    Department of Haematology, Royal Free and University College Medical School Hampstead Campus, London, United Kingdom
    J Med Virol 80:1952-8. 2008
  6. ncbi Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis
    Duncan A Clark
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 193:912-6. 2006
  7. ncbi Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles
    Katherine N Ward
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School UCL Campus, Windeyer Institute of Medical Sciences, 46 Cleveland St, London W1T 4JF, United Kingdom
    J Clin Microbiol 44:1571-4. 2006
  8. ncbi Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele
    Anna Virgili
    Molecular Cytogenetics Laboratory, Academic Hematology, University College London Cancer Institute, Royal Free Campus, London, United Kingdom
    Cancer Res 71:5381-6. 2011
  9. ncbi 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
    Andrew J Steele
    Department of Hematology, Cancer Institute, University College London Medical School, London, United Kingdom
    Blood 114:1217-25. 2009
  10. ncbi Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia
    Alistair G Reid
    University College London, Department of Academic Haematology, London, UK
    Br J Haematol 121:419-27. 2003

Collaborators

  • Hoe Nam Leong
  • Duncan A Clark
  • David Marin
  • P D Griffiths
  • Brian J P Huntly
  • Dragana Milojkovic
  • Tomasz Skorski
  • Katherine N Ward
  • Anna Virgili
  • Alistair G Reid
  • Andrew J Steele
  • Anastasios Chanalaris
  • Valeria A S De Melo
  • Jane F Apperley
  • Colin Grace
  • Anthony R Green
  • Tomasz Stoklosa
  • Mateusz Koptyra
  • Eliza Glodkowska-Mrowka
  • Yashodhara Dasgupta
  • R Gitendra Wickremasinghe
  • Birunthini C Yogashangary
  • Mark W Lowdell
  • Edward R Samuel
  • Archibald G Prentice
  • Janet M North
  • Kate Cwynarski
  • A Victor Hoffbrand
  • Panagiotis Kottaridis
  • Stephen M Hart
  • Diana Brazma
  • Valeria As De Melo
  • Julie Howard-Reeves
  • Mikel Valgañón
  • Eveline Hennig
  • Colin D Grace
  • Lynda J Campbell
  • Michael W Deininger
  • Dietger Niederwieser
  • Nick Bown
  • Nick Telford
  • Helen Walker

Detail Information

Publications11

  1. ncbi Deletions adjacent to BCR and ABL1 breakpoints occur in a substantial minority of chronic myeloid leukemia patients with masked Philadelphia rearrangements
    Valeria A S De Melo
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Cancer Genet Cytogenet 182:111-5. 2008
    ..1 and 22q11.2 chromosomal regions, regardless of the subsequent mechanism of chromosomal rearrangement...
  2. ncbi FISH mapping of Philadelphia negative BCR/ABL1 positive CML
    Anna Virgili
    Molecular Cytogenetics, Academic Haematology, Royal Free and UCL Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Mol Cytogenet 1:14. 2008
    ..Here we present FISH mapping data of BCR and ABL1 flanking regions and associated chromosomal rearrangements in 9 Ph negative BCR/ABL1 positive CML patients plus the cell line CML-T1...
  3. ncbi Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines
    Anna Virgili
    Academic Haematology, University College London Cancer Institute, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Mol Cytogenet 3:15. 2010
    ..1-qter to investigate whether they carried two identical copies of the Ph chromosome or, instead, one or both Ph contained cryptic imbalances of some regions...
  4. ncbi Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia
    Elisabeth P Nacheva
    UCL School of Medicine, Cancer Institute, Academic Haematology, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK
    BMC Genomics 11:41. 2010
    ....
  5. ncbi Human herpesvirus 6 integrates within telomeric regions as evidenced by five different chromosomal sites
    Elisabeth P Nacheva
    Department of Haematology, Royal Free and University College Medical School Hampstead Campus, London, United Kingdom
    J Med Virol 80:1952-8. 2008
    ..Large epidemiological studies of chromosomal integration are required to identify further telomeric sites, geographical or racial variation and possible clinical consequences...
  6. ncbi Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis
    Duncan A Clark
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 193:912-6. 2006
    ..We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease...
  7. ncbi Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles
    Katherine N Ward
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School UCL Campus, Windeyer Institute of Medical Sciences, 46 Cleveland St, London W1T 4JF, United Kingdom
    J Clin Microbiol 44:1571-4. 2006
    ..The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration...
  8. ncbi Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele
    Anna Virgili
    Molecular Cytogenetics Laboratory, Academic Hematology, University College London Cancer Institute, Royal Free Campus, London, United Kingdom
    Cancer Res 71:5381-6. 2011
    ..Taken together, our results indicate that loss of the normal ABL1 kinase may serve as a key prognostic factor that exerts major impact on CML treatment outcomes...
  9. ncbi 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
    Andrew J Steele
    Department of Hematology, Cancer Institute, University College London Medical School, London, United Kingdom
    Blood 114:1217-25. 2009
    ..Our data suggest that PAS may represent a novel class of drug that induces apoptosis in CLL cells independently of p53 status by a mechanism involving Noxa up-regulation...
  10. ncbi Survival implications of molecular heterogeneity in variant Philadelphia-positive chronic myeloid leukaemia
    Alistair G Reid
    University College London, Department of Academic Haematology, London, UK
    Br J Haematol 121:419-27. 2003
    ..Our study showed that, despite the existence of several levels of genomic heterogeneity in variant Ph-positive CML, der(9) deletion status is the key prognostic factor...
  11. ncbi Deletions of the derivative chromosome 9 do not account for the poor prognosis associated with Philadelphia-positive acute lymphoblastic leukemia
    Alistair G Reid
    Blood 99:2274-5. 2002