Research Topics
Genomes and GenesSpecies | A MostynSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
Audience response technology: engaging and empowering non-medical prescribing students in pharmacology learningJoanne S Lymn
School of Nursing, Midwifery and Physiotherapy, University of Nottingham, Queens Medical Centre, Nottingham, UK
BMC Med Educ 10:73. 2010..The aim of this project, therefore, was to incorporate and evaluate the use the KS in promoting pharmacology understanding in NMP students...- Influence of size at birth on the endocrine profiles and expression of uncoupling proteins in subcutaneous adipose tissue, lung, and muscle of neonatal pigsAlison Mostyn
Centre for Reproduction and Early Life, Institute of Clinical Research, Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, NG7 2UH United Kingdom
Am J Physiol Regul Integr Comp Physiol 288:R1536-42. 2005..In conclusion, low birth weight is associated with tissue-specific effects on UCP expression. It remains to be established whether these subsequently contribute to pathological conditions such as diabetes... - Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigsA Mostyn
Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK
J Endocrinol 183:121-31. 2004..In conclusion, we have demonstrated that porcine genotype influences the expression and abundance of UCP2 and 3, an influence which may, in part, be due to the distinctive endocrine profiles associated with each genotype... - Early programming of adipose tissue function: a large-animal perspectiveAlison Mostyn
Early Life Nutrition Research Unit, Academic Child Health, Division of Human Development and Nottingham Respiratory Medicine Biomedical Research Unit, School of Clinical Sciences, Queen s Medical Centre, University Hospitals, Nottingham NG7 2UH, UK
Proc Nutr Soc 68:393-400. 2009..The experimental models, potential mechanisms and regulators of the early programming of adipose tissue in large mammalian species will be summarised in the present review... - Influence of porcine genotype on the abundance of thyroid hormones and leptin in sow milk and its impact on growth, metabolism and expression of key adipose tissue genes in offspringAlison Mostyn
Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
J Endocrinol 190:631-9. 2006.... - Differential effects of leptin administration on the abundance of UCP2 and glucocorticoid action during neonatal developmentM G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Am J Physiol Endocrinol Metab 289:E1093-100. 2005..These effects may be important in the development of these tissues, thereby optimizing lung function and fat growth... - Tissue-specific effects of leptin administration on the abundance of mitochondrial proteins during neonatal developmentM G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
J Endocrinol 187:81-8. 2005..These effects may be important in the regulation of neonatal tissue development and potentially for optimising metabolic control mechanisms in later life... - Ontogeny and nutritional manipulation of mitochondrial protein abundance in adipose tissue and the lungs of postnatal sheepA Mostyn
Academic Division of Child Health, School of Human Development, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH, UK
Br J Nutr 90:323-8. 2003..These mitochondrial adaptations within both adipose tissue and the lungs of offspring born to previously nutrient-restricted mothers may compromise adipose tissue and lung function during periods of environmental stress... - Increased uncoupling protein-2 mRNA abundance and glucocorticoid action in adipose tissue in the sheep fetus during late gestation is dependent on plasma cortisol and triiodothyronineM G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham NG7 2UH, UK
J Physiol 567:283-92. 2005..In conclusion, plasma cortisol and T3 are both required for the late gestation rise in UCP2 mRNA and differentially regulate glucocorticoid action in fetal adipose tissue in the sheep during late gestation... - Prolactin, prolactin receptor and uncoupling proteins during fetal and neonatal developmentS Pearce
Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, UK
Proc Nutr Soc 62:421-7. 2003..Taken together these findings suggest that PRL could be an important endocrine factor during pregnancy and early postnatal life... - Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lungD P Yakubu
Institute of Clinical Research, Centre for Reproduction and Early Life, University of Nottingham, Nottingham NG7 2UH, UK
Reproduction 134:823-30. 2007..The divergence in mitochondrial response between tissues to maternal nutrient restriction early in pregnancy further reflects these differential ontogenies... - Hormonal and nutritional regulation of adipose tissue mitochondrial development and function in the newbornA Mostyn
Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, United Kingdom
Exp Clin Endocrinol Diabetes 112:2-9. 2004..It could also add substantially to our understanding of pathological conditions such as obesity and non-insulin dependent diabetes... - Prolactin, the prolactin receptor and uncoupling protein abundance and function in adipose tissue during development in young sheepS Pearce
Centre for Reproduction and Early Life, Institute of Clinical Research, Queen's Medical Centre, University Hospital, Nottingham, NG7 2UH, UK
J Endocrinol 184:351-9. 2005..In conclusion, we have demonstrated a close relationship between the ontogeny of UCP1 and the PRLR. Exogenous PRL administration elicits a thermogenic effect suggesting an important role for the PRLR in regulating UCP1 function... - Different effects of maternal parity, cold exposure and nutrient restriction in late pregnancy on the abundance of mitochondrial proteins in the kidney, liver and lung of postnatal sheepD P Yakubu
Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham NG7 2UH, UK
Reproduction 133:1241-52. 2007.... - Fetal and neonatal adipose maturation: a primary site of cytokine and cytokine-receptor actionT Stephenson
Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH
Biochem Soc Trans 29:80-5. 2001.... - Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2M G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
J Endocrinol 188:375-86. 2006..As a consequence, changes in glucocorticoid sensitivity and mitochondrial protein abundance have the potential to be used to identify those at greatest risk of developing later lung disease... - Effect of administration of recombinant human leptin during the neonatal period on the plasma concentration and gene expression of leptin in the pigletJ C Litten
Department of Agricultural Sciences, Imperial College London, Wye, Ashford, Kent, UK
Biol Neonate 87:1-7. 2005..Chronic leptin administration appeared to have a beneficial influence on growth rate and body conformation, which may in part be attributed to alterations in metabolism and nutrient partitioning... - Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lungM G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, UK
J Physiol 565:159-69. 2005.... - The role of leptin in the transition from fetus to neonateA Mostyn
Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, UK
Proc Nutr Soc 60:187-94. 2001.... - Influence of cortisol on adipose tissue development in the fetal sheep during late gestationA Mostyn
Academic Division of Child Health, School of Human Development, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH, UK
J Endocrinol 176:23-30. 2003..It remains to be established whether effects on UCP1 protein are directly regulated by cortisol alone or mediated by other anabolic fetal hormones such as triiodothyronine... - Cytokines and cytokine receptors in fetal growth and developmentM E Symonds
Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, U K
Biochem Soc Trans 29:33-7. 2001..An increased understanding of these interactions is likely to have important implications for a number of potentially pathological conditions, including infection, obesity and hypertension... - Maternal nutrient restriction during placental growth, programming of fetal adiposity and juvenile blood pressure controlM E Symonds
School of Human Development, University Hospital, Nottingham, UK
Arch Physiol Biochem 111:45-52. 2003..Reduced maternal nutrition during the period of rapid placental growth may therefore contribute to hypertension in later life through physiological and vascular adaptations during fetal life... - Influence of birth weight on gene regulators of lipid metabolism and utilization in subcutaneous adipose tissue and skeletal muscle of neonatal pigsP J Williams
Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG72UH, UK
Reproduction 138:609-17. 2009..It remains to be seen whether these developmental changes alter an individual's susceptibility to metabolic syndrome... - Endocrine and nutritional regulation of fetal adipose tissue developmentM E Symonds
Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, UK
J Endocrinol 179:293-9. 2003..The pronounced nutritional sensitivity of fetal adipose tIssue to both increased and decreased maternal nutrition may explain why the consequences of an adverse nutritional environment persist into later life... - The effect of maternal prolactin infusion during pregnancy on fetal adipose tissue developmentH Budge
Academic Division of Child Health, School of Human Development, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH, UK
J Endocrinol 174:427-33. 2002.... - Animal models for the study of the developmental origins of health and diseaseSarah McMullen
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
Proc Nutr Soc 68:306-20. 2009..It is proposed that the integration of evidence from a variety of different models is required for the advancement of understanding within the field... - Ambient temperature, maternal dexamethasone, and postnatal ontogeny of leptin in the neonatal lambJayson Bispham
Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, UK
Pediatr Res 52:85-90. 2002.... - Differential effects of leptin on thermoregulation and uncoupling protein abundance in the neonatal lambAlison Mostyn
Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH
FASEB J 16:1438-40. 2002..In conclusion, leptin administration to neonatal lambs improves thermoregulation and promotes the loss of UCP1 in brown adipose tissue... - Maternal nutritional programming of fetal adipose tissue development: long-term consequences for later obesityHelen Budge
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, United Kingdom
Birth Defects Res C Embryo Today 75:193-9. 2005..The extent to which changes in dietary habits, both during pregnancy and in later life, may act to contribute to the current explosion in childhood and adult obesity remains a scientific and public health challenge to us all... - Differential effects of fetal number and maternal nutrition in late gestation on prolactin receptor abundance and adipose tissue development in the neonatal lambHelen Budge
Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom
Pediatr Res 53:302-8. 2003..An increase in fetal number results in greater PRLR abundance, which, in conjunction with a decrease in maternal nutrition, results in up-regulation of specific mitochondrial proteins... - The influence of maternal protein nutrition on offspring development and metabolism: the role of glucocorticoidsK Almond
Academic Division of Child Health, School of Clinical Sciences, E Floor East Block, University Hospital, Nottingham NG7 2UH, UK
Proc Nutr Soc 71:198-203. 2012..This increase in GC sensitivity was similar to the programming effects observed following maternal protein restriction or global undernutrition during pregnancy... - Ontogeny and nutritional programming of adiposity in sheep: potential role of glucocorticoid action and uncoupling protein-2Muhuntha G Gnanalingham
Centre for Reproduction and Early Life, Institute of Chemical Research, University of Nottingham, United Kingdom
Am J Physiol Regul Integr Comp Physiol 289:R1407-15. 2005..We conclude that the continual rise in glucocorticoid action and fat mass after birth may underlie the development of later obesity. The magnitude of this adaptation is partly dependent on maternal food intake through pregnancy...