N Avrion Mitchison

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Patterned variation in murine MHC promoters
    N Avrion Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 99:10561-6. 2002
  2. ncbi Human congenital diseases with mixed modes of inheritance have a shortage of recessive disease. A demographic scenario?
    N Avrion Mitchison
    Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Ann Hum Genet 75:688-93. 2011
  3. ncbi From ENU mutagenesis to population genetics
    N Avrion Mitchison
    Institute of Ophthalmology, University College London, London, UK
    Mamm Genome 19:221-5. 2008
  4. ncbi A survey of H2 gene sequences, including new wild-derived genes
    N A Mitchison
    Department of Immunology and Molecular Pathology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    Int J Immunogenet 34:3-12. 2007
  5. ncbi Fundamental immunology and what it can teach us about HIV vaccine development
    N Avrion Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, London, UK
    Curr Drug Targets Infect Disord 5:87-93. 2005
  6. ncbi Does the polymorphism of MHC class II promoters matter?
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
    Cell Immunol 233:162-5. 2005
  7. ncbi Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection
    N A Mitchison
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Immunol Lett 97:63-7. 2005
  8. ncbi T-cell-B-cell cooperation
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
    Nat Rev Immunol 4:308-12. 2004
  9. ncbi Self/nonself discrimination among immunoregulatory (CD4) T cells
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1P 6DB
    Semin Immunol 12:179-83; discussion 257-344. 2000
  10. ncbi Polymorphism in regulatory gene sequences
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street, London W1P 6DB, UK
    Genome Biol 2:COMMENT2001. 2001

Detail Information

Publications19

  1. ncbi Patterned variation in murine MHC promoters
    N Avrion Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 99:10561-6. 2002
    ..The dimorphic allelic lineages are in marginally detectable linkage disequilibrium with the exon 2 sequences, particularly in H2Aa, thus lending further support to the coevolution hypothesis...
  2. ncbi Human congenital diseases with mixed modes of inheritance have a shortage of recessive disease. A demographic scenario?
    N Avrion Mitchison
    Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Ann Hum Genet 75:688-93. 2011
    ..The deficit fits well with the standard model of demographic change since the neolithic era, and may also reflect natural selection acting on heterozygotes...
  3. ncbi From ENU mutagenesis to population genetics
    N Avrion Mitchison
    Institute of Ophthalmology, University College London, London, UK
    Mamm Genome 19:221-5. 2008
  4. ncbi A survey of H2 gene sequences, including new wild-derived genes
    N A Mitchison
    Department of Immunology and Molecular Pathology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    Int J Immunogenet 34:3-12. 2007
    ..The H2Eb(p) alleles form a distinct group, associated with their lack of the recombination hot spot located between exon 2 and exon 3. The collection is expected to prove useful in guiding functional and evolutionary studies...
  5. ncbi Fundamental immunology and what it can teach us about HIV vaccine development
    N Avrion Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, London, UK
    Curr Drug Targets Infect Disord 5:87-93. 2005
    ..Finally we urge that vaccine trials should include storage of individual DNA samples, in order to gain better understanding of the genetic parameters of vaccine efficacy...
  6. ncbi Does the polymorphism of MHC class II promoters matter?
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
    Cell Immunol 233:162-5. 2005
    ....
  7. ncbi Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection
    N A Mitchison
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Immunol Lett 97:63-7. 2005
    ..In view of recent re-evaluation of the role of the respiratory burst these findings are compatible with the view that haploinsufficiency occurs particularly among rate-limiting genes that operate in regulatory/signaling pathways...
  8. ncbi T-cell-B-cell cooperation
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
    Nat Rev Immunol 4:308-12. 2004
  9. ncbi Self/nonself discrimination among immunoregulatory (CD4) T cells
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1P 6DB
    Semin Immunol 12:179-83; discussion 257-344. 2000
    ..Activation induced cell death, containment, anergy and deviation constitute subsidiary mechanisms, and sequestration/neglect is important in limiting the scope of deletion...
  10. ncbi Polymorphism in regulatory gene sequences
    N A Mitchison
    Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street, London W1P 6DB, UK
    Genome Biol 2:COMMENT2001. 2001
    ....
  11. ncbi Natural variation in immune responsiveness, with special reference to immunodeficiency and promoter polymorphism in class II MHC genes
    N A Mitchison
    Department of Immunology, University College London Medical School, UK
    Hum Immunol 61:177-81. 2000
    ..MHC class II gene promoters differ in their capacity to favor Th1 (or reciprocally Th2) responses, thus suggesting that promoter polymorphism is sustained by the greater flexibility in response that this confers on heterozygotes...
  12. ncbi Aqueous humor alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection
    T H Flynn
    Department of Ocular Immunology, UCL Institute of Ophthalmology, London, UK
    Am J Transplant 8:1537-43. 2008
    ..Aqueous humor samples offer a unique opportunity to analyze components of the allogeneic response in direct contact with donor tissue but without artifacts inherent in examination of tissue...
  13. ncbi The immunological synapse
    R J Creusot
    Windeyer Institute of Medical Science, University College London, 46 Cleveland Street, W1T 4JF, UK
    Mol Immunol 38:997-1002. 2002
    ..In exploring this form of control we are learning something of general importance about cis-regulation...
  14. ncbi Testing the theory of immune selection in cancers that break the rules of transplantation
    Ariberto Fassati
    MRC Centre for Medical Molecular Virology, University College London, UK
    Cancer Immunol Immunother 59:643-51. 2010
    ..Here, we (a) survey old and new transplantation experiments that test the possibility of selection and (b) survey how transmissible tumours of dogs and Tasmanian devils provide naturally evolved tests of immune surveillance...
  15. ncbi Epistasis: the key to understanding immunological disease?
    N Avrion Mitchison
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Eur J Immunol 41:2152-4. 2011
    ..A study in this issue of the European Journal of Immunology uses in-depth analysis of genome-wide mapping by polymorphic microsatellite markers to shed light on the genomic control of autoimmunity and self-tolerance...
  16. ncbi Variable response to a candidate cancer vaccine antigen: MHC control of the antibody response in the rat to avian erythroblastosis virus (AEV)-encoded epithelial growth factor receptor but not AEV-encoded thyroid hormones receptor
    N Nardi
    Imperial Cancer Research Fund Tumor Immunology Unit, University College London, United Kingdom
    Mol Med 1:563-7. 1995
    ....
  17. ncbi The role of HLA promoters in autoimmunity
    Brigitte Müller-Hilke
    Institute of Immunology, Medical Faculty, Schillingallee 70, 18055 Rostock, Germany
    Curr Pharm Des 12:3743-52. 2006
    ..We here summarise our knowledge of HLA promoter polymorphisms and how these translate into differential expression, T cell polarisation and inflammation. We discuss current strategies for pharmaceutical intervention in HLA expression...