Research Topics
Species | U MenonSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Ovarian cancer screeningFarhad Alexander-Sefre
Department of Gynaecological Oncology, St Bartholomew's and the Royal London Medical and Dental School, London EC1A 7BE
Hosp Med 63:210-3. 2002..However, the results so far do not justify routine screening until the impact of screening on mortality has been assessed in larger randomized trials...
The sine qua non of discovering novel biomarkers for early detection of ovarian cancer: carefully selected preclinical samplesIan Jacobs
Gynaecological Oncology, UCL EGA Institute for Women s Health, London, UK
Cancer Prev Res (Phila) 4:299-302. 2011..This research has important implications for the future design of cancer biomarker studies...
Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trialsMatthew Burnell
Gynaecological Oncology, EGA Institute for Women s Health, University College London, London, UK
Trials 12:61. 2011..This report assesses the extent of the HVE still prevalent in UKCTOCS and considers how certain shortfalls in mortality and incidence can be related to differences in socioeconomic status...
OSPACS: Ultrasound image management systemWill Stott
Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, Paul O Gorman Building, Gower Street, London WC1E 6BT, UK
Source Code Biol Med 3:11. 2008..However, these systems are usually not suitable for managing large collections of anonymized ultrasound images gathered during a clinical screening trial...
Recruitment to multicentre trials--lessons from UKCTOCS: descriptive studyUsha Menon
Gynaecological Oncology, UCL EGA Institute for Women s Health, London W1T 7DN
BMJ 337:a2079. 2008..To describe the factors that contributed to successful recruitment of more than 200,000 women to the UK Collaborative Trial of Ovarian Cancer Screening, one of the largest ever randomised controlled trials...
Ovarian cancer: challenges of early detectionUsha Menon
Gynaecological Cancer Research Centre, UCL Elizabeth Garrett Institute of Women's Health, Maple House, London, UK
Nat Clin Pract Oncol 4:498-9. 2007
Views of BRCA gene mutation carriers on preimplantation genetic diagnosis as a reproductive option for hereditary breast and ovarian cancerU Menon
Gynaecological Oncology, UCL Institute for Women s Health, 149 Tottenham Court Road, London, UK
Hum Reprod 22:1573-7. 2007..This is the first report on views of BRCA gene mutation carriers on use of PGD for HBOC...
Decline in use of hormone therapy among postmenopausal women in the United KingdomUsha Menon
Department of Gynaecological Oncology, UCL Institute for Women s Health, London, UK
Menopause 14:462-7. 2007..This study documents recent trends in HT use in postmenopausal women in the United Kingdom...
Assessing the malignant potential of ovarian inclusion cysts in postmenopausal women within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a prospective cohort studyA Sharma
Gynaecological Cancer Research Centre, University College London, EGA Institute for Women s Health, UK
BJOG 119:207-19. 2012..To evaluate the malignant potential of ultrasound-detected ovarian inclusion cysts in the development of ovarian cancer (OC) in postmenopausal women...
Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10,418 British women aged 54-65M S Hunter
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
BJOG 119:40-50. 2012..We report on these variables in a large UK cohort of postmenopausal women...
Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation statusR Manchanda
Department of Gynaecological Oncology, EGA Institute for Women s Health, UCL, London, UK
BJOG 118:814-24. 2011..To compare surgical outcomes and occult cancer rates at risk-reducing salpingo-oophorectomy in BRCA carriers and high-risk women who had not undergone genetic testing...
A comparison of national cancer registry and direct follow-up in the ascertainment of ovarian cancerN Macdonald
Department of Gynaecological Oncology, St Bartholomew s Hospital, London, UK
Br J Cancer 80:1826-7. 1999..NHSCR ascertainment was incomplete and direct follow-up provided additional information. These findings have implications for interpretation of national cancer statistics and for use of the NHSCR in research trials...
Novel one-stop multidisciplinary follow-up clinic significantly improves cancer risk management in BRCA1/2 carriersG Pichert
Clinical Genetics Department, Guy s and St Thomas NHS Foundation Trust, Guys Hospital, 7th Floor Borough Wing, Great Maze Pond Road, SE1 9RT, London, UK
Fam Cancer 9:313-9. 2010..001). Our novel MDOSC designed to devise an individually tailored cancer risk management strategy had a high uptake amongst our BRCA1/2 carriers. Attendance resulted in improved breast and ovarian cancer risk management...
Recent developments in ovarian cancer screeningU Menon
Gynaecology Cancer Research Unit, St Bartholomew s and the Royal London Medical and Dental School, London, UK
Curr Opin Obstet Gynecol 12:39-42. 2000..Although the results do not justify ovarian cancer screening in the general population, the data support the need for a larger randomized trial powered to assess the impact of screening on mortality...
Feasibility of screening for ovarian cancer using symptoms as selection criteriaB D Rufford
Department of Gynaecological Oncology, The Royal Marsden NHS Foundation Trust, London, UK
BJOG 114:59-64. 2007..Failure to recognise these symptoms may result in a delay in referral and diagnosis. We assess the feasibility of screening for ovarian cancer using symptoms as selection criteria...
Postmenopausal women undergoing transvaginal ultrasound screening prefer not to have chaperonesA Sharma
Department of Gynaecological Oncology, Institute of Women s Health, UCL, London, UK
BJOG 113:954-7. 2006..Of greater consequence to women was the gender of the ultrasonographer, with 83.3% expressing a preference for a female ultrasonographer. This needs to be considered in making decisions about allocation of scarce resources...
Ovarian cancer screening in the general populationU Menon
Gynaecology Cancer Research Unit, St Bartholomew s and the Royal London Medical and Dental School, London, UK
Curr Opin Obstet Gynecol 13:61-4. 2001..A randomized control trial to definitively answer this question is now underway in the UK. This study also addresses the issues of target population, compliance, health economics and physical and psychological morbidity of screening...
Preanalytic influence of sample handling on SELDI-TOF serum protein profilesJohn F Timms
Translational Research Laboratory, Institute of Women s Health, University College London, London, United Kingdom
Clin Chem 53:645-56. 2007..We investigated whether older collections with longer sample transit times yield useful protein profiles, and sought to establish the most feasible collection methods for future clinical proteomic studies...
Circulating methylated DNA: a new generation of tumor markersMartin Widschwendter
Department of Gynaecological Oncology, UCL Elizabeth Garrett Institute for Women's Health, University College London, London, United Kingdom
Clin Cancer Res 12:7205-8. 2006
Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle studyMartin Widschwendter
Department of Gynecological Oncology, UCL Institute for Women s Health, University College London, London, United Kingdom
PLoS ONE 3:e2656. 2008..However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear...
Hereditary non-polyposis colorectal cancer or Lynch syndrome: the gynaecological perspectiveRanjit Manchanda
Department of Gynaecological Oncology, Institute for Women s Health, University College London, London, UK
Curr Opin Obstet Gynecol 21:31-8. 2009..This review covers the gynaecological aspects of managing women with HNPCC: diagnostic criteria, molecular tests for diagnosis, cancer risks and different strategies for surveillance and prevention...
Screening for ovarian cancerAdam N Rosenthal
Institute for Women s Health, University College London, Elizabeth Garrett Anderson Hospital, London, UK
Clin Obstet Gynecol 49:433-47. 2006..Current screening tests, clinical trials in the general and high-risk populations, screening acceptability and costs are reviewed in this article...
An epigenetic signature in peripheral blood predicts active ovarian cancerAndrew E Teschendorff
Medical Genomics Group, University College London Cancer Institute, University College London, London, United Kingdom
PLoS ONE 4:e8274. 2009..However, to date no study has evaluated the diagnostic and predictive potential of such markers in a large case control cohort and on a genome-wide basis...
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle studyMartin Widschwendter
Department of Gynecological Oncology, Institute for Women s Health, University College London, United Kingdom
Int J Cancer 125:2214-8. 2009....
Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohortIan Jacobs
Gynaecological Oncology, UCL EGA Institute for Women s Health, London, UK
Lancet Oncol 12:38-48. 2011..Transvaginal ultrasound (TVS) is a possible screening test, but there have been no large-scale studies. We report the performance of TVS screening in a large cohort...
Peptides generated ex vivo from serum proteins by tumor-specific exopeptidases are not useful biomarkers in ovarian cancerJohn F Timms
Institute for Women s Health, University College London, London, UK
Clin Chem 56:262-71. 2010..We tested 2 complementary serum profiling strategies to see if similar peptides could be found that discriminate ovarian cancer from benign cases and healthy controls...
Screening for ovarian cancerUsha Menon
Gynaecology Oncology Unit, Bart's and the London Queen Mary's School of Medicine and Dentistry, London, UK
Best Pract Res Clin Obstet Gynaecol 16:469-82. 2002..In addition, trials in the high-risk population aimed at optimizing the current strategy have commenced in both the USA and the UK...
DNA methylation of polycomb group target genes in cores taken from breast cancer centre and peripheryEvangelia Ourania Fourkala
Department of Gynaecological Oncology, Institute for Women s Health, University College London, 1st Floor, Maple House, 149 Tottenham Court Road, London, W1T 7DN, UK
Breast Cancer Res Treat 120:345-55. 2010..Further work will reveal if methylation of PCGT genes will serve as a robust means for the clinical detection and assessment of breast cancer...
Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle studyM Widschwendter
The Institute for Women s Health, University College London, London, UK
Br J Cancer 101:160-5. 2009..In this study, we analysed the capacity of serum from breast cancer cases and controls to transactivate the oestrogen receptor alpha (ER-alpha) and beta (ER-beta)...
Influences on multidisciplinary team decision-makingA Lanceley
Gynaecological Cancer Research Centre, Institute for Women s Health, University College London, London, United Kingdom
Int J Gynecol Cancer 18:215-22. 2008..Practitioners' sphere of expertise, Department of Health policy, and familiarity of the team with the patient are key factors in shaping decision-making in MDMs...
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)Usha Menon
Gynaecological Oncology, University College London Elizabeth Garrett Anderson Institute for Women s Health, London, UK
Lancet Oncol 10:327-40. 2009..This report summarises the outcome of the prevalence (initial) screen in UKCTOCS...
Ovarian cancer screeningUsha Menon
Gynaecology Cancer Research Centre, Department of Gynaecological Oncology, Institute of Women's Health, University College London, London, UK
CMAJ 171:323-4. 2004
Screening for gynaecological cancersA Sharma
Department of Gynaecological Oncology, Institute of Women s Health, University College London, 149, Tottenham Court Road, London W1T 7DN, UK
Eur J Surg Oncol 32:818-24. 2006..This review covers advances in cervical cancer screening, strategies being investigated in ovarian cancer screening and the lack of justification in screening for endometrial, vulval and vaginal cancers...
Management of women who test positive for high-risk types of human papillomavirus: the HART studyJ Cuzick
Cancer Research UK, London, UK
Lancet 362:1871-6. 2003..We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women...
Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancerL Quaye
Gynaecological Oncology Department, UCL EGA Institute for Women s Health, University College London, London, UK
Br J Cancer 100:993-1001. 2009..034) and a haplotype in BRAF that had a protective effect (P(global)=0.005). In conclusion, these data provide borderline evidence of association for common allelic variation in the NMI with risk of epithelial OC...
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survivalLydia Quaye
Gynaecological Oncology Unit, UCL EGA Institute for Women s Health, University College London, UK
Hum Mol Genet 18:1869-78. 2009..In summary, a novel in vitro functional approach in ovarian cancer cells has identified RBBP8 as a gene for which both germline genetic variation and somatic alterations in tumours are associated with survival in ovarian cancer patients...
The value of ovarian cancer screeningAarti Sharma
Gynaecological Cancer Research Centre, Institute of Womens Health, University College London, London W1T 7DN
Br J Hosp Med (Lond) 67:314-7. 2006..This suggests that screening may impact on disease mortality. This review addresses the current methods of screening, the ongoing trials and future of screening for ovarian cancer...
Laparoscopic extraperitoneal paraaortic lymphadenectomy: a study of its applications in gynecological malignanciesG Mehra
Clinical Research, Gynecological Oncology Unit, Barking, Havering and Redbridge NHS Trust and St. Bartholomew's Hospital, London, UK
Gynecol Oncol 93:189-93. 2004..It can be effectively applied in staging early ovarian cancers to determine the need for adjuvant chemotherapy...
Surgical morbidity associated with radical trachelectomy and radical hysterectomyF Alexander-Sefre
Department of Gynaecological Oncology, St Bartholomew s Hospital, North East London Gynaecological Cancer Centre, London, UK
Gynecol Oncol 101:450-4. 2006..To examine intra-operative, short and longer term morbidity associated with Radical Trachelectomy (RT) within our cohort of patients, compared with conventional Radical Hysterectomy (RH)...
Progress and challenges in screening for early detection of ovarian cancerIan J Jacobs
Department of Gynaecological Oncology, Cancer Institute, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London EC1M 6GR, United Kingdom
Mol Cell Proteomics 3:355-66. 2004..There is a sound basis for optimism that further developments in serum proteomic analysis will provide powerful methods for screening in ovarian cancer and many other diseases...
Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancerUsha Menon
Department of Gynecological Oncology, Institute of Women's Health, University College London
J Clin Oncol 23:7919-26. 2005..It is being used in the United Kingdom Collaborative Trial of Ovarian Cancer Screening and in the United States in both the Cancer Genetics Network and the Gynecology Oncology Group trials of high-risk women...
A breast cancer fear scale: psychometric developmentVictoria L Champion
School of Nursing, Indiana University, USA
J Health Psychol 9:753-62. 2004..All items loaded on a single factor and theoretical relationships were verified by linear and logistic regression. The Cronbach alpha for the scale was.91...
Consortium analysis of 7 candidate SNPs for ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
Int J Cancer 123:380-8. 2008..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
Calculation of the risk of ovarian cancer from serial CA-125 values for preclinical detection in postmenopausal womenSteven J Skates
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Oncol 21:206s-210s. 2003..We conducted a study to assess the screening performance of the risk of ovarian cancer calculation based on serial CA-125 levels from prospectively collected serum samples compared with a fixed CA-125 cutoff...
Comparisons of tailored mammography interventions at two months postinterventionVictoria L Champion
Indiana University School of Nursing, Indianapolis 46202 5107, USA
Ann Behav Med 24:211-8. 2002..5. Logistic regression indicates that postintervention mammography status in all three intervention groups was significantly better than usual care, with odds ratios ranging from 1.66 (telephone only) to 2.16 (telephone plus mail)...
Health-related research among Amish women: a review of findingsMelissa K Thomas
Community Outreach, Grant Riverside Methodist Hospitals, 3726A Olentangy River Road, Columbus, OH 43214, USA
Curr Womens Health Rep 2:208-13. 2002..It is imperative that more evidence-based research be conducted to determine the cultural aspects and other factors that may influence health in this population...
Beliefs associated with fecal occult blood test and colonoscopy use at a worksite colon cancer screening programUsha Menon
University of Utah College of Nursing, Salt Lake City, UT 84112, USA
J Occup Environ Med 45:891-8. 2003..Findings may be used to develop interventions designed to improve CRC screening rates...
Colorectal cancer screening: an overview of current trendsSusan M Rawl
Indiana University School of Nursing, 1111 Middle Drive, NU 338, Indianapolis, IN 46202, USA
Nurs Clin North Am 37:225-45, v. 2002..S. population. Nurses have a significant role to play in assisting individuals to incorporate regular colorectal cancer screening into their health maintenance routines...
Comparison of tailored interventions to increase mammography screening in nonadherent older womenVictoria Champion
Indiana University School of Nursing, 1111 Middle Drive, Indianapolis, IN 46202, USA
Prev Med 36:150-8. 2003..Recent increases in mammography use have led to a decrease in mortality from breast cancer...
Population-based cancer screeningVictoria L Champion
Indiana University of Indianapolis, Indianapolis, IN, USA
Oncol Nurs Forum 29:853-61. 2002..To provide an overview of current issues surrounding the prevention of and screening for lung, breast, cervical, colorectal, ovarian, prostate, and skin cancer...
Screening for ovarian cancerSara Lewis
Gynaecology Oncology Unit, Bart s and The London, Queen Mary s School of Medicine and Dentistry, UK
Expert Rev Anticancer Ther 3:55-62. 2003..Large randomized trials are now underway to provide definitive data on the impact of screening on mortality and address morbidity, health economics and psychosocial issues...
Interactive, culturally sensitive education on colorectal cancer screeningUsha Menon
University of Illinois at Chicago, Chicago, Illinois 60625, USA
Med Care 46:S44-50. 2008..Increasing colorectal cancer screening (CRCS) can have a substantial positive impact on morbidity and mortality...
The effect of telephone versus print tailoring for mammography adherenceVictoria Champion
Indiana University, School of Nursing, 1111 Middle Drive, Indianapolis, IN 46202, United States
Patient Educ Couns 65:416-23. 2007..The purpose of this intervention was to increase mammography adherence in women who had not had a mammogram in the last 15 months...
Breast and cervical cancer screening practices and inventions among Chinese, Japanese, and Vietnamese AmericansFrances Lee-Lin
School of Nursing, Oregon Health and Science University, Portland, USA
Oncol Nurs Forum 32:995-1003. 2005..To review research on breast and cervical cancer screening practices among Chinese, Japanese, and Vietnamese Americans...
Health belief model variables as predictors of progression in stage of mammography adoptionUsha Menon
University of Illinois Chicago, College of Nursing, 845 S Damen Avenue, MC 802, Chicago, IL 60612, USA
Am J Health Promot 21:255-61. 2007..Identify predictors of change in mammography stage for nonadherent women so that appropriate stage-based interventions can be developed...
Development of a self-efficacy scale for mammographyVictoria Champion
Indiana University, School of Nursing, Indianapolis, IN, USA
Res Nurs Health 28:329-36. 2005..Cronbach alpha was used to test internal consistency reliability. A Cronbach alpha coefficient of .87 was obtained. The mammography self-efficacy scale evidenced content and construct validity...
Breast cancer beliefs and mammography screening practices among Chinese American immigrantsFrances Lee-Lin
School of Nursing, Oregon Health and Science University, Portland, OR 97239, USA
J Obstet Gynecol Neonatal Nurs 36:212-21. 2007..To explore knowledge and beliefs (perceived risk factors, susceptibility, benefits, common barriers, and cultural barriers) in relation to mammography screening practices among Chinese American women...
Perceptions of colon cancer screening by stage of screening test adoptionUsha Menon
University of Illinois Chicago College of Nursing, Chicago, IL 60612, USA
Cancer Nurs 30:178-85. 2007..As such, this study is one of very few to quantify beliefs across stages of colorectal cancer and identify significant differences across stages, laying the foundation for the development and testing of stage-based interventions...
Health behaviors in cancer survivorsDeborah K Mayer
The Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
Oncol Nurs Forum 34:643-51. 2007..To describe health behaviors of cancer survivors by cancer diagnosis and to compare them to people without a personal or family cancer history...
A cost-effectiveness comparison of three tailored interventions to increase mammography screeningRobert M Saywell
Department of Family Medicine and Bowen Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5102, USA
J Womens Health (Larchmt) 13:909-18. 2004..This study examined the cost-effectiveness of three combinations of tailored telephone and mailed intervention strategies for increasing adherence to mammography...
Gynaecological ultrasonography: expertise countsUsha Menon
Lancet Oncol 9:88-9. 2008
Motivational interviewing and colorectal cancer screening: a peek from the inside outStephanie Wahab
Portland State University, Graduate School of Social Work, Portland, OR 97207, USA
Patient Educ Couns 72:210-7. 2008..We discuss in this paper the training and supervision of study interventionists, in order to enhance practice and research knowledge concerned with fidelity issues in motivational interview interventions...
Screening practices in cancer survivorsDeborah K Mayer
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 345, Boston, MA 02111, USA
J Cancer Surviv 1:17-26. 2007..The purpose of this study was to examine the impact of a cancer diagnosis on survivors' screening beliefs and practices compared to those without a cancer history...
Tailored interventions for screening mammography among a sample of initially non-adherent women: when is a booster dose important?Celette Sugg Skinner
Department of Surgery, Duke University Medical Center and Program in Prevention, Detection and Control Research, Duke University Comprehensive Cancer, 2424 Erwin Rd, Ste 602, DUMC 2715, Durham, NC 27705, USA
Patient Educ Couns 65:87-94. 2007..To assess added value of a booster dose of a tailored mammography intervention...
