Research Topics
| Isabelle M MedanaSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Axonal injury in cerebral malariaIsabelle M Medana
Nuffield Departments of Clinical Laboratory Sciences and Medicine, Level 5 Lab R 5501, The John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom
Am J Pathol 160:655-66. 2002..falciparum malaria infection. Disruption in axonal transport may represent a final common pathway leading to neurological dysfunction in cerebral malaria...- The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, Oxford Wellcome Centre for Tropical and Infectious Diseases, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Infect Dis 185:650-6. 2002..CSF lactate remained an independent and significant predictor of poor outcome... - Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe diseaseIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
Histopathology 57:282-94. 2010..This study aimed to investigate the role of hypoxia and induction of the vascular endothelial growth factor (VEGF) pathway in the neuropathophysiology of severe malaria... - Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
Malar J 8:261. 2009.... - Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, Oxford Wellcome Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, UK
J Infect Dis 188:844-9. 2003..Elevated levels of KA in children with CM may serve to contain injury in the developing brain, which is more susceptible to excitotoxic damage than is the adult brain... - Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Academic Block, Level 4, John Radcliffe Hospital Headington, Oxford OX3 9DU, UK
Trans R Soc Trop Med Hyg 99:610-7. 2005..On admission to hospital, patients with severe malaria had biochemical evidence of brain parenchymal damage predominantly affecting axons... - Axonal and astrocyte injury markers in the cerebrospinal fluid of Kenyan children with severe malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, Academic Block, Level 4, The John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
J Neurol Sci 258:93-8. 2007..This study provides evidence that axonal injury is associated with malaria coma and identifies the potential role of severe anaemia, acidosis and hyperparasitaemia to causing brain parenchymal damage in children with malaria... - Cerebral calpain in fatal falciparum malariaI M Medana
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK
Neuropathol Appl Neurobiol 33:179-92. 2007..Our findings implicate a role for calpains in the modulation of disease progression in CM... - Sequestration and microvascular congestion are associated with coma in human cerebral malariaMark J Ponsford
Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, United Kingdom
J Infect Dis 205:663-71. 2012..Increased microvascular congestion accompanies coma in CM, associated with parasite sequestration in the cerebral microvasculature... - Coma in fatal adult human malaria is not caused by cerebral oedemaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
Malar J 10:267. 2011.... - Human cerebral malaria and the blood-brain barrierIsabelle M Medana
Malaria Research Group, Nuffield Department of Clinical Laboratory Sciences, Oxford University, Oxford, UK
Int J Parasitol 36:555-68. 2006..This review will summarise evidence for these mechanisms from human studies of cerebral malaria and discuss the possible role for BBB dysfunction in this complex and challenging disease... - Axonal damage: a key predictor of outcome in human CNS diseasesI M Medana
Department of Clinical Laboratory Sciences, University of Oxford, UK
Brain 126:515-30. 2003..We consider the possible pathogenetic mechanisms involved and how increasing understanding of these may lead to more effective therapeutic or preventive interventions... - Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malariaI M Medana
Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, Oxford University, UK
Neuropathol Appl Neurobiol 27:421-33. 2001..There was no evidence for a specific pattern of widespread irreversible cell damage in those patients with cerebral malaria... - Immunopathogenesis of cerebral malariaNicholas H Hunt
Molecular Immunopathology Unit, Institute for Biomedical Research, University of Sydney, Sydney, NSW, Australia
Int J Parasitol 36:569-82. 2006.... - Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cellsNavakanit Sachanonta
Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Asian Pac J Allergy Immunol 26:37-45. 2008..We conclude that P. falciparum iRBC can bind host VEGF-R on the erythrocyte membrane and accumulate host VEGF within the parasitophorous vacuole, which may have a trophic effect on parasite growth... - Plasmodium falciparum and the blood-brain barrier--contacts and consequencesIsabelle M Medana
J Infect Dis 195:921-3. 2007