T M McKeever

..A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood...

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..Studies in adults, in particular those based on objective outcomes such as bronchial hyperresponsiveness, skin sensitisation, and lung function, are limited...

..To date, few studies have examined the relation between dietary food patterns and forced expiratory volume in 1 s (FEV(1)) or respiratory symptoms...

..The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV1)...

..Whether twins have a reduced risk of allergic disease is also unclear. We have investigated these questions in a birth cohort analysis of the West Midlands General Practice Research Database (GPRD)...

..We have studied the relation between individual fatty acid intakes, lung function and self-reported respiratory symptoms and diagnoses in a representative sample of more than 13,000 Dutch adults...

..5, -76.6) lower than persons without diabetes. This effect was greater in those with poorly controlled diabetes. These findings suggest that impaired glucose autoregulation is associated with impaired lung function...

..We hypothesized that acetaminophen use may also be associated with chronic obstructive pulmonary disease (COPD) and decreased lung function...

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..Our findings suggest that exposure to antibiotics and to infections in utero is a potentially important risk factor in the development of allergic disease...

..This study suggests that a high dietary intake of vitamin C, or of foods rich in this vitamin, may reduce the rate of loss of lung function in adults and thereby help to prevent chronic obstructive pulmonary disease...

..We examined the effect of vaccination for diphtheria; polio; pertussis and tetanus; or measles, mumps, and rubella on the incidence of physician-diagnosed asthma and eczema...

..A study was undertaken to assess the association between maternal asthma and gestational exposure to asthma medications with risk of congenital malformation in offspring...

..28, 95% CI 1.24-1.32). In conclusion, pneumonia is an important public health problem and the incidence of pneumonia is higher in people at the extremes of age, men and people living in socially deprived areas...

..We hypothesized that eCO may permit non-invasive assessment of disease activity in adults with asthma and bronchial reactivity...

..As a result of this cohort effect, the prevalence of allergic sensitization has increased in this general adult population sample...

..We tested the hypotheses that exposure to H. pylori reduces the risk of asthma and allergic disease and is associated with a decrease in lung function...

..15 (95% CI: 1.13, 1.17) and 1.08 (95% CI: 1.06, 1.10), respectively. The authors found no evidence that the fertility rates of women with asthma, eczema, or hay fever are lower than those of women in the general population...

..If causal, this may have implications for the understanding of the processes that are involved in the pathophysiology of decline in lung function...

..The aim of this study was to investigate the association between blood coagulation activation as measured by plasma d-dimers and lung function...

..We found no convincing evidence to suggest that babies born by caesarean, forceps, or breech delivery had an increased risk of developing allergic disease...

..We investigated the short- and long-term survival of people with pneumonia diagnosed in general practice as compared to the general population for all ages...

..We hypothesized that this effect may represent a new non-invasive method to assess bronchial reactivity and other measures of asthma control...

..Pneumonia is a common diagnosis in general practice in the United Kingdom. Previous studies suggest that commonly prescribed drugs in general practice may influence pneumonia mortality...

..Observational epidemiologic studies have suggested that a low-sodium diet is associated with reduced mortality...

..The evidence is conflicting however. Our aim was to investigate the effect of these drugs on pneumonia using population-based data from the UK...

..An increase in weight is a risk factor for cardiovascular disease and cancer. This increased risk may be mediated by inflammation, but no long-term data are available on the effect of weight gain on systemic inflammation...

..Previous studies have raised concern that women with asthma have increased risks of adverse obstetric and pediatric complications, but these have generally been underpowered...

..However, few large studies have assessed the relationship between systemic inflammation as measured by CRP and decline in lung function prospectively in a randomly selected population...

..2 new patients per 100,000 population annually. Respiratory services also need to provide adequate monitoring and early treatment of infection in these patients...

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..The use of antibiotics might be associated with early diagnoses of allergic disease...

..These may be mediated by an increase in systemic inflammation. We assessed if serologic evidence of infection with H. pylori is associated with increased serum C-reactive protein (CRP) levels...