Research Topics
Genomes and Genes
| Iain B McInnesSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT studyHilary A Capell
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
Ann Rheum Dis 66:235-41. 2007..Aim: To establish whether a combination of SASP and MTX is superior to either drug alone in patients with rheumatoid arthritis with a suboptimal response to 6 months of SASP...- New cytokine targets in inflammatory rheumatic diseasesLaura Connell
Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
Best Pract Res Clin Rheumatol 20:865-78. 2006..Since we wish to reflect the current predominant research effort, we will focus primarily on rheumatoid arthritis (RA) based studies... - Psoriatic arthritis: current topicsDavid McCarey
Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow, Scotland, G31 2ER, UK
Curr Rheumatol Rep 9:442-8. 2007..Finally, new insights into the disorder's genetic antecedents are emerging as more cohorts of patients undergo advanced genetic screening methods... - Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?David W McCarey
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK
Arthritis Res Ther 7:55-61. 2005..Together with their known vasculoprotective effects, this growing body of evidence provides compelling support for longer-term trials of statin therapy in human disease such as rheumatoid arthritis... - New strategies to control inflammatory synovitis: interleukin 15 and beyondI B McInnes
Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, Department of Medicine, University of Glasgow, UK
Ann Rheum Dis 62:ii51-4. 2003 - A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62Iain B McInnes
Department of Immunology and Center for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom
J Immunol 171:2127-33. 2003..quot; ES-62 represents one such mechanism. We now provide proof of concept that parasite-derived immunomodulatory strategies offer a novel therapeutic opportunity in inflammatory arthritis... - Leukotrienes, mast cells, and T cellsIain B McInnes
Centre for Rheumatic Diseases, University of Glasgow, Scotland, UK
Arthritis Res Ther 5:288-9. 2003 - Interleukin-15: a new cytokine target for the treatment of inflammatory diseasesIain B McInnes
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
Curr Opin Pharmacol 4:392-7. 2004..These data hold promise for therapeutic targeting in ongoing human studies and those in the near future... - Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritisIain B McInnes
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland
Curr Rheumatol Rep 6:336-42. 2004..The possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed... - Interleukin-18: a therapeutic target in rheumatoid arthritis?Iain B McInnes
Division of Immunology, Infection and Inflammation, University of Glasgow, UK
Arthritis Res Ther 7:38-41. 2005..The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets... - Cytokine networks--towards new therapies for rheumatoid arthritisIain B McInnes
Centre for Rheumatic Diseases, University of Glasgow, UK
Nat Clin Pract Rheumatol 1:31-9. 2005..As therapeutic goals move from disease control towards remission induction, development of the capacity for cytokine targeting to modify the underlying immune dysregulation remains a major priority... - Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cellsI B McInnes
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK
Arthritis Res 2:374-8. 2000..Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets... - Cytokines in the pathogenesis of rheumatoid arthritisIain B McInnes
Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
Nat Rev Immunol 7:429-42. 2007..Here, we discuss the crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of rheumatoid arthritis... - Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritisIain B McInnes
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland
Curr Pain Headache Rep 9:405-11. 2005..The possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed... - Rheumatoid arthritis. From bench to bedsideI B McInnes
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
Rheum Dis Clin North Am 27:373-87. 2001..Through this rapid evolution, close communication between physician and scientist is essential... - Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in miceAshley M Miller
Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
Circ Res 107:650-8. 2010..The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear... - IL-33 induces skin inflammation with mast cell and neutrophil activationAxel J Hueber
Glasgow Biomedical Research Centre, University of Glasgow, UK
Eur J Immunol 41:2229-37. 2011..These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis... - IL-33 exacerbates autoantibody-induced arthritisDamo Xu
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
J Immunol 184:2620-6. 2010.... - Identifying the cells breaching self-tolerance in autoimmunityRobert A Benson
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
J Immunol 184:6378-85. 2010..We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity... - IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammationMariola Kurowska-Stolarska
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 183:6469-77. 2009..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation... - Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cellsAndrew M Platt
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 185:1558-67. 2010..Thus, we provide a novel mode of action for abatacept with profound implications for its potential usefulness in early inflammatory arthropathies associated with autoantibody expression... - A novel anti-inflammatory role for simvastatin in inflammatory arthritisBernard P Leung
Department of Immunology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
J Immunol 170:1524-30. 2003..These data clearly illustrate the therapeutic potential of statin-sensitive pathways in inflammatory arthritis... - IL-33 reduces the development of atherosclerosisAshley M Miller
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
J Exp Med 205:339-46. 2008..In conclusion, IL-33 may play a protective role in the development of atherosclerosis via the induction of IL-5 and ox-LDL antibodies... - Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritisDarren L Asquith
Glasgow Biomedical Research Center, Division of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow, UK
Arthritis Rheum 60:2655-65. 2009..This study was therefore undertaken to explore the biologic mechanisms of LXRs in vivo and in vitro in an experimental inflammatory arthritis model... - IL-33 exacerbates antigen-induced arthritis by activating mast cellsDamo Xu
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
Proc Natl Acad Sci U S A 105:10913-8. 2008..Thus, this IL-1 superfamily member represents a therapeutic target for RA... - A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migrationClive S McKimmie
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdam
Blood 113:4224-31. 2009..These data highlight a novel role for TLR ligands, such as BLP, in regulating leukocyte retention and migration away from innate immune lesions via discrete constitutive and inflammatory chemokine receptor regulation... - Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1Clive S McKimmie
Division of Immunology, Grasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 181:8171-81. 2008..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes... - Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritisDarren L Asquith
University of Glasgow, Glasgow, UK
Arthritis Rheum 62:472-7. 2010..To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA)... - IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cellsWanda Niedbala
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Eur J Immunol 37:3021-9. 2007..Thus, IL-35 is a novel anti-inflammatory cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development... - Chemoattraction of human T cells by IL-18Mousa Komai-Koma
Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, United Kingdom
J Immunol 170:1084-90. 2003..These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases... - Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritisSarah L Jongbloed
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
J Immunol 182:963-8. 2009..pDC may offer a net anti-inflammatory function in the context of articular breach of tolerance. Such data will be vital in informing DC modulatory/therapeutic approaches... - Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membraneAnne Crilly
Institute of Infection, Immunity and Infl ammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Ann Rheum Dis 70:1130-7. 2011..To date, few data have directly addressed whether synovial cytokine and chemokine production is modified by PDE4... - Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and miceLindsay M Maclellan
University of Glasgow, Glasgow, UK
Arthritis Rheum 63:3897-907. 2011..The aim of this study was to explore an entirely novel route of immunoglobulin-mediated regulation, involving simultaneous suppression of the inflammatory and erosive processes in the synovium... - A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammationBernard P Leung
Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
J Immunol 169:7071-7. 2002..Furthermore, this disease process is mediated through both adaptive and innate effects of DCs; first, priming of autoreactive T cells and, second, induction of local inflammation via mediators such as TNF... - Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune diseaseAgapitos Patakas
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
Immunol Lett 138:38-46. 2011.... - IL-33 is a chemoattractant for human Th2 cellsMousa Komai-Koma
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Eur J Immunol 37:2779-86. 2007..These data therefore demonstrate that IL-33 is a selective Th2 chemoattractant associated with the pro-inflammatory property of this novel cytokine... - Embracing novel cytokines in RA - complexity grows as does opportunity!Axel J Hueber
Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, 120 University Place Glasgow, G12 8TA, U K
Best Pract Res Clin Rheumatol 24:479-87. 2010.... - Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cellsPasquale Maffia
Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
J Immunol 173:151-6. 2004..Furthermore, the ability to track these cells in vivo will make feasible studies revealing the dynamic role of T cells in arthritis... - Mast cells express IL-17A in rheumatoid arthritis synoviumAxel J Hueber
Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 184:3336-40. 2010.... - A novel therapy of murine collagen-induced arthritis with soluble T1/ST2Bernard P Leung
Division of Immunology, Infection, and Inflammation and Centre for Rheumatic Diseases, Royal Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
J Immunol 173:145-50. 2004..Together these results demonstrate that sST2-Fc may provide a novel approach in treating chronic autoimmune conditions by inhibiting the release of proinflammatory cytokines... - The role of innate mediators in inflammatory responseFoo Y Liew
Department of Immunology and Bacteriology, University of Glasgow, G11 6NT, UK
Mol Immunol 38:887-90. 2002..Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis... - Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infectionShauna Culshaw
Department of Immunology and Bacteriology, Western Infirmary, Glasgow, UK
Eur J Immunol 35:1438-44. 2005.... - A novel anti-inflammatory role of simvastatin in a murine model of allergic asthmaAnne McKay
Division of Immunology, Infection, and Inflammation, Section of Respiratory Medicine, University of Glasgow, Glasgow, United Kingdom
J Immunol 172:2903-8. 2004..Simvastatin treatment did not alter serum total IgE or OVA-specific IgG1 and IgG2a levels. These data demonstrate the therapeutic potential of statin-sensitive pathways in allergic airways disease... - Expression and alternative processing of IL-18 in human neutrophilsSusan E Robertson
CRD, Division of Immunology, Infection and Inflammation, Glasgow Royal Infirmary, Glasgow, UK
Eur J Immunol 36:722-31. 2006..Through cytosolic, membrane or secretory expression of such processing enzymes, together with generation of IL-18 itself, neutrophils likely play a critical role in regulating IL-18 activities during early innate immune responses... - Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritisWilliam R Ferrell
University of Glasgow, UK
Ann Rheum Dis 69:2051-4. 2010..This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in osteoarthritis... - Murine neutrophils present Class II restricted antigenShauna Culshaw
Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Immunol Lett 118:49-54. 2008..These studies demonstrate that murine neutrophils present MHC Class II-restricted peptides and induce T cell proliferation, confirming findings in human neutrophils, and demonstrate a novel pro inflammatory effect of murine neutrophils... - Emerging cytokine targets in rheumatoid arthritisDarren L Asquith
Glasgow Biomedical Research Centre, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
Curr Opin Rheumatol 19:246-51. 2007..Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive to remission induction, requires that further therapeutic targets be identified... - Role for TNF in atherosclerosis? Lessons from autoimmune diseaseGayle E McKellar
Center for Rheumatic Diseases, Glasgow, Royal Infirmary, Glasgow, UK
Nat Rev Cardiol 6:410-7. 2009..Moreover, such data obtained in chronic inflammatory diseases likely have relevance to primary atherosclerosis... - Simultaneous activation of the liver X receptors (LXR? and LXR?) drives murine collagen-induced arthritis disease pathologyDarren L Asquith
Correspondence to Dr Darren L Asquith, Glasgow Biomedical Research Centre, Institute of Immunity, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK
Ann Rheum Dis 70:2225-8. 2011..It has previously been shown that dual activation of the Liver X Receptors (LXR? and LXR?) by the agonist, GW3965, enhances pathology in a murine model of collagen-induced arthritis... - MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritisMariola Kurowska-Stolarska
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
Proc Natl Acad Sci U S A 108:11193-8. 2011..Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target... - Characterization of the anticollagen antibody response in a new model of chronic polyarthritisPaola Conigliaro
University of Glasgow, Glasgow, UK
Arthritis Rheum 63:2299-308. 2011..This study was undertaken to create a new model of chronic autoimmune polyarthritis and characterize the associated CII-specific B cell response... - TNF-blocking therapies: an alternative mode of action?Brian S W Choo-Kang
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
Trends Immunol 26:518-22. 2005.... - Animal models of rheumatoid arthritisDarren L Asquith
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
Eur J Immunol 39:2040-4. 2009..Here, we describe these animal models and discuss their advantages and limitations... - Hypoxia: a critical regulator of early human tendinopathyNeal L Millar
Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
Ann Rheum Dis 71:302-10. 2012..To seek evidence for the role of hypoxia in early human tendinopathy, and thereafter to explore mechanisms whereby tissue hypoxia may regulate apoptosis, inflammatory mediator expression and matrix regulation in human tenocytes... - Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell functionGao Xuzhu
Correspondence to Dr Damo Xu, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, B421, 120 University Place, Glasgow G12 8TA, UK
Ann Rheum Dis 71:129-35. 2012..As such, it could mediate anti-inflammatory properties of the latter and offer novel therapeutic utility in is own right... - Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trialDavid W McCarey
Centre for Rheumatic Diseases, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
Lancet 363:2015-21. 2004..INTERPRETATION: These data show that statins can mediate modest but clinically apparent anti-inflammatory effects with modification of vascular risk factors in the context of high-grade autoimmune inflammation... - Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritisNaveed Sattar
Department of Pathological Biochemistry and Centre for Rheumatic Diseases, North Glasgow Hospitals University NHS Trust, Glasgow Royal Infirmary, Glasgow, Scotland, UK
Circulation 108:2957-63. 2003..Unraveling such complex relationships in which exaggerated inflammation-risk factor interactions are prevalent may elicit novel insights to effector mechanisms in vascular disease generally... - Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritisSarah L Jongbloed
Division of Immunology, Infection and Inflammation, 10 Alexandra Parade, Glasgow, G31 2ER, UK
Arthritis Res Ther 8:R15. 2006..Maturation is incomplete in the inflamed synovial compartment. Immature DCs in SF may contribute to the perpetuation of inflammation via sampling of the inflamed synovial environment, and in situ presentation of arthritogenic antigen... - An investigation of the inflammatory cytokine and chemokine network in systemic sclerosisVeronica Codullo
Institute of Infection, Immunity and Infl ammation, University of Glasgow, Glasgow, UK
Ann Rheum Dis 70:1115-21. 2011..The atypical chemokine receptor D6 has a critical role in this physiological balance. To explore potential deregulation of this system in SSc, inflammatory chemokine and D6 expression were compared with that in healthy controls (HC)... - Disease-associated functions of IL-33: the new kid in the IL-1 familyFoo Y Liew
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
Nat Rev Immunol 10:103-10. 2010..Thus IL-33 could be a new target for therapeutic intervention across a range of diseases... - Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritisJ Alastair Gracie
Center for Rheumatic Diseases and Department of Immunology, University of Glasgow, Glasgow, UK
Curr Opin Rheumatol 14:270-5. 2002..The key recent observations in these areas, particularly in the extracellular compartment, are reviewed... - What can the periodontal community learn from the pathophysiology of rheumatoid arthritis?Shauna Culshaw
Glasgow Dental Hospital and School, University of Glasgow, Glasgow, UK
J Clin Periodontol 38:106-13. 2011..The aim of this paper is to provide a narrative review of the aetiopathogeneis and treatments of rheumatoid arthritis (RA), focusing on aspects that may share commonality with periodontitis... - Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1Clive S McKimmie
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
J Immunol 181:3353-63. 2008..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes... - Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled studyNaveed Sattar
University of Glasgow, Glasgow, UK
Arthritis Rheum 56:831-9. 2007.... - Atypical chemokine receptors in inflammatory diseaseManish Patel
Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, UK
Curr Mol Med 9:86-93. 2009..This review will describe the basic biology of such receptors and speculate on their potential as therapeutic agents moving forward... - Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonistElizabeth B Kelso
University of Glasgow, Glasgow, UK
Arthritis Rheum 56:765-71. 2007.... - Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammationAshley M Miller
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G128TA, UK
Curr Pharm Des 17:1-8. 2011..In this review we will focus on the role of pro-inflammatory cytokines and their inhibitors in RA, and whether they may be causal in the accelerated atherosclerosis seen in these patients... - Interleukin 27 attenuates collagen-induced arthritisW Niedbala
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
Ann Rheum Dis 67:1474-9. 2008.... - Vascular comorbidity in rheumatoid arthritis: potential mechanisms and solutionsNaveed Sattar
Section of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Royal Infirmary, Scotland, UK
Curr Opin Rheumatol 17:286-92. 2005..To summarise recent evidence for elevated risk of coronary heart disease (CHD) in rheumatoid arthritis (RA) and explore explanatory mechanisms and modalities that may lessen such risk... - Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriageRhoda Wilson
University Department of Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
Eur J Obstet Gynecol Reprod Biol 115:51-4. 2004..To compare cytokine levels in serum from non-pregnant women with a history of recurrent miscarriage with those found in non-pregnant women with no such history... - Inflammation is present in early human tendinopathyNeal L Millar
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom
Am J Sports Med 38:2085-91. 2010..The authors previously identified increased levels of inflammatory cytokines in an early human model of tendinopathy and sought to extend these studies to the cellular analysis of tissue... - Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic miceCristina Guillen
Department of Immunology and Bacteriology, Western Infirmary, Royal Infirmary, Glasgow, United Kingdom
J Immunol 168:3950-7. 2002..These results demonstrate that human Lf can mediate both antimicrobial and immunomodulatory activities with downstream effects on the outcome of immune pathology in infectious and inflammatory disease... - Imaging inflammation in real time--future of nanoparticlesAxel J Hueber
Centre for Rheumatic Diseases, University of Glasgow, Glasgow, G12 8TA, UK
Autoimmunity 42:368-72. 2009..Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation... - Interleukin-18J Alastair Gracie
Centre for Rheumatic Diseases, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
J Leukoc Biol 73:213-24. 2003..Subsequent cloning of human IL-18 cDNA revealed 65% homology with murine IL-18 [(3) ] and showed that both contain an unusual leader sequence consisting of 35 amino acids at their N terminus... - Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot studyPeter V Balint
Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland
J Rheumatol 29:2209-13. 2002..To compare joint and soft tissue aspiration using a conventional technique with an ultrasound (US) guided technique... - Immune regulation in psoriasis and psoriatic arthritis--recent developmentsAxel J Hueber
Division of Immunology, Infection and Inflammation, 120 University Place, Glasgow G128QQ, United Kingdom
Immunol Lett 114:59-65. 2007..We also describe the pathways that are believed to link such inflammatory pathways to articular matrix dysregulation... - Do statins offer therapeutic potential in inflammatory arthritis?I B McInnes
Centre for Rheumatic Diseases, Department of Vascular Biochemistry, University of Glasgow, UK
Ann Rheum Dis 63:1535-7. 2004 - Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriageRhoda Wilson
Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK
Am J Reprod Immunol 51:156-9. 2004..How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines... - Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18X Q Wei
Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
J Immunol 166:517-21. 2001..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases... - Role of interleukin 18 in rheumatoid arthritisF Y Liew
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
Ann Rheum Dis 62:ii48-50. 2003 - Role of interleukin 15 and interleukin 18 in inflammatory responseF Y Liew
Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, UK
Ann Rheum Dis 61:ii100-2. 2002..Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis... - IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic backgroundD Xu
Department of Immunology and Bacteriology, University of Glasgow, Glasgow, GB
Eur J Immunol 30:3147-56. 2000..These data therefore provide a novel mechanism for Th2 cell development. Thus, IL-18, a cytokine constitutively expressed by cells of the innate response, is capable of inducing Th2 cell differentiation in the absence of IL-4... - Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathyP V Balint
Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK
Ann Rheum Dis 61:905-10. 2002..To compare ultrasonography (US) with clinical examination in the detection of entheseal abnormality of the lower limb in patients with spondyloarthropathy (SpA)... - Abnormal IL-2 receptor levels in non-pregnant women with a history of recurrent miscarriageR Wilson
University Departments of Medicine, Glasgow Royal Infirmary, UK
Hum Reprod 18:1529-30. 2003..This study compared interleukin-2 receptor (IL-2R) levels in non-pregnant women with a history of recurrent miscarriage with those found in serum from a non-pregnant group with no such history... - Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritisM B Nickdel
Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Ann Rheum Dis 68:1059-66. 2009..However, the mechanisms underlying this phenomenon were unclear... - A role for IL-18 in neutrophil activationB P Leung
Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, United Kingdom
J Immunol 167:2879-86. 2001..Together, these data define a novel role for IL-18 in activating neutrophils and thereby promoting early innate immune responses... - The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritisM M Harnett
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
Ann Rheum Dis 67:518-23. 2008..As a first step to developing ES-62-based drugs, the aim of this study was to determine whether the PC-moiety of ES-62 was responsible for its anti-inflammatory actions... - Interleukin-12 to interleukin 'infinity': the rationale for future therapeutic cytokine targetingE J R Anderson
Division of Immunology, Infection and Inflammation, Centre for Rheumatic Diseases, University of Glasgow, Glasgow, Scotland, UK
Springer Semin Immunopathol 27:425-42. 2006 - State-of-the-art: rheumatoid arthritisIain B McInnes
Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, UK
Ann Rheum Dis 69:1898-906. 2010..Throughout the review, emphasis is placed on unanswered questions and challenges in this exciting field... - The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivoM Orchardson
Department of Immunology and Bacteriology and Center of Rheumatic Disease, University of Glasgow, Glasgow, United Kingdom
J Immunol 167:277-82. 2001..Thus, the Sushi domain is critical for the functional activity of sIL-15Ralpha... - A proinflammatory role of IL-18 in the development of spontaneous autoimmune diseaseE Esfandiari
Department of Immunology and Bacteriology, Centre of Rheumatic Disease, Glasgow, United Kingdom
J Immunol 167:5338-47. 2001..These data therefore show that IL-18 is an important mediator of lupus-like disease and may thus be a novel target for therapeutic intervention of spontaneous autoimmune diseases... - Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammationS Hutchison
Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Clin Exp Immunol 151:114-22. 2008.... - Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived areaJ Hamilton
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, United Kingdom
Ann Rheum Dis 60:566-72. 2001..To compare the risk-benefit ratio of intramuscular gold (gold sodium thiomalate (GST)) and methotrexate (MTX) in a population with rheumatoid arthritis (RA) from a deprived area... - Disease association of two distinct interleukin-18 promoter polymorphisms in Caucasian rheumatoid arthritis patientsJ A Gracie
Centre for Rheumatic Diseases, University of Glasgow, Glasgow, Scotland, UK
Genes Immun 6:211-6. 2005..2 vs 1.2%) and in Scottish RA patients (4.1 vs 0.9%) than in the respective HD cohorts. These observations suggest that SNP of both positions contribute to the genetic background of RA pathogenesis... - An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammationS Hutchison
Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
Clin Exp Immunol 155:107-16. 2009.... - Improved medical and surgical management of cervical spine disease in patients with rheumatoid arthritis over 10 yearsJ D Hamilton
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland, UK
Ann Rheum Dis 59:434-8. 2000..2) To determine if surgical outcome has improved since the series published from this unit in 1987. (3) To examine the role of magnetic resonance imaging (MRI) in the diagnosis of cervical myelopathy... - Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axisS C Wong
Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow, United Kingdom
Growth Horm IGF Res 18:369-78. 2008..To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA... - Role of interleukin 33 in human immunopathologyG E J Murphy
Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8QQ, UK
Ann Rheum Dis 69:i43-47. 2010..In this paper the basic biology of IL33 is described together with that of its cognate receptor, ST2L, and the existing knowledge base for its potential role in mediating human pathology across a range of diseases is defined... - A fork in the pathway to inflammation and arthritisFoo Y Liew
Nat Med 11:601-2. 2005 - Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrateMichele Bombardieri
Rheumatology Department, GKT School of Medicine, King s College London, UK
Arthritis Res Ther 6:R447-56. 2004.... - IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 productionWaldiceu A Verri
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Eur J Immunol 37:3373-80. 2007....