Research Topics
| Claudia MauriSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Regulatory B cells in autoimmunity: developments and controversiesClaudia Mauri
Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
Nat Rev Rheumatol 6:636-43. 2010..A particular emphasis is placed on B(REG)-cell function in rheumatic diseases...- Prevention of arthritis by interleukin 10-producing B cellsClaudia Mauri
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
J Exp Med 197:489-501. 2003..Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders... - Immune regulatory function of B cellsClaudia Mauri
Center for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, United Kingdom email
Annu Rev Immunol 30:221-41. 2012..This review reports and discusses the factors that are important for Breg differentiation and for their effector function in both mouse and human... - Is there a feudal hierarchy amongst regulatory immune cells? More than just TregsClaudia Mauri
Centre for Rheumatology Research, University College London, Department of Medicine, Cleveland Street, London, UK
Arthritis Res Ther 11:237. 2009..However, it has become clearer that other immune suppressive cells inhibit auto-reactivity as effectively as Tregs. The function of Tregs and other regulatory cells in rheumatoid arthritis will be discussed in this review... - The 'short' history of regulatory B cellsClaudia Mauri
Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
Trends Immunol 29:34-40. 2008..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies... - Cells of the synovium in rheumatoid arthritis. B cellsClaudia Mauri
Centre for Rheumatology Research, Department of Medicine, University College London, Cleveland Street, London, W1T 4JF, UK
Arthritis Res Ther 9:205. 2007..In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease... - Regulation of immunity and autoimmunity by B cellsClaudia Mauri
Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom
Curr Opin Immunol 22:761-7. 2010..A complete analysis of their function in immune-mediated diseases is required for possible future use of B(regs) as a part of new clinical strategies for treating autoimmune diseases and in the induction of transplant tolerance... - Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune responseClaudia Mauri
Center for Rheumatology Research, Windeyer Institute of Medical Sciences, University College London, London, UK
Arthritis Rheum 48:839-45. 2003.... - Novel suppressive function of transitional 2 B cells in experimental arthritisJamie G Evans
Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
J Immunol 178:7868-78. 2007..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential... - Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosusElizabeth C Jury
Department of Medicine, Centre for Rheumatology, University College London, London, UK
Eur J Immunol 40:569-78. 2010..Collectively our data identify CTLA-4 dysfunction as a potential cause for abnormal T-cell activation in patients with SLE, which could be targeted for therapy... - Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr micePaul A Blair
Department of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
J Immunol 182:3492-502. 2009..Taken together, our results suggest a novel cellular approach for the amelioration of experimental lupus... - CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patientsPaul A Blair
Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
Immunity 32:129-40. 2010..Altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders... - IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responsesRita Vasconcellos
Centre for Rheumatology Research, University College London, London WC1E 6JF, United Kingdom
J Immunol 187:3402-12. 2011..The restoration of disease phenotype after anti-IL-27 administration indicates that the IL-12p35 subunit acts as negative regulator of the developing IL-27 response in this model of arthritis... - Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cellsNatalie A Carter
Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom
J Immunol 186:5569-79. 2011..Thus, IL-10-producing B cells restrain inflammation by promoting differentiation of immunoregulatory over proinflammatory T cells... - Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritisFabian Flores-Borja
Centre for Rheumatology, Division of Medicine, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom
Proc Natl Acad Sci U S A 105:19396-401. 2008..Our results suggest that defects in CTLA-4 could contribute to abnormal Treg function in RA and may represent a target for therapy for inducing long-lasting remission... - Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-betaSuchita Nadkarni
Centre for Rheumatology, Department of Medicine, Windeyer Institute, University College London, London W1T 4JF, England, UK
J Exp Med 204:33-9. 2007..Therefore, manipulation of a proinflammatory environment could represent a therapeutic strategy for the induction of T reg cells and the restoration of tolerance... - Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosusElizabeth C Jury
Department of Medicine, Centre for Rheumatology, University College London, United Kingdom
J Immunol 177:7416-22. 2006..These findings demonstrate the potential for atorvastatin to target lipid raft-associated signaling abnormalities in autoreactive T cells and provide a rationale for its use in therapy of autoimmune disease... - Biosprayed spleen cells integrate and function in mouse modelsNatalie A Carter
Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London, W1T 4JF, UK
Analyst 136:3434-7. 2011..Hence these biotechniques hold great potential for use in the development of three-dimensional cultures, tracking and monitoring cell-interactions and in vitro modelling of disease-states and therapeutics... - Restoring the balance: harnessing regulatory T cells for therapy in rheumatoid arthritisFabian Flores-Borja
Department of Medicine, University College London, London, UK
Eur J Immunol 38:934-7. 2008..Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer... - Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 miceSarah Lawman
Department of Medicine, University College London, London, United Kingdom
J Immunol 173:7641-6. 2004..This is the first demonstration that atorvastatin can delay the progression of a spontaneous autoimmune disease and may specifically benefit patients with systemic lupus erythematosus... - Lipid-Antigen Presentation by CD1d(+) B Cells Is Essential for the Maintenance of Invariant Natural Killer T CellsAnneleen Bosma
Centre for Rheumatology Research, Division of Medicine, University College London, The Rayne Building, 4 th Floor, Room 419, 5 University Street, London WC1E 6JF, UK
Immunity 36:477-90. 2012..We propose that healthy B cells are pivotal for iNKT cell homeostasis... - Natural serum IgM maintains immunological homeostasis and prevents autoimmunityJessica J Manson
Department of Rheumatology, University College London, London, UK
Springer Semin Immunopathol 26:425-32. 2005..This review focuses on these new areas of research, which also show that many pathologies not normally recognised as having an immunological basis are modulated by serum IgM... - Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapyMichael R Ehrenstein
Dept of Medicine, Centre for Rheumatology, Windeyer Institute, University College London, London W1T 4JF, England, UK
J Exp Med 200:277-85. 2004.... - If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicineMichael R Ehrenstein
Department of Medicine, University College London, London W1T 4JF, UK
J Exp Med 204:2249-52. 2007..Studies aimed at understanding the mechanism of action of biologic agents will yield significant benefits for experimental medicine... - Statins for atherosclerosis--as good as it gets?Michael R Ehrenstein
N Engl J Med 352:73-5. 2005 - Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathwayGiovanna Schiavoni
Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
J Immunol 173:1266-75. 2004..pneumophila infection in mouse models of susceptible macrophages and suggest the existence of different pathways for the control of intracellular bacteria in macrophages...