P W Mathieson

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi How much VEGF do you need?
    Peter W Mathieson
    J Am Soc Nephrol 17:602-3. 2006
  2. ncbi Is complement a target for therapy in renal disease?
    P W Mathieson
    Academic Renal Unit, University of Bristol, Bristol, England, United Kingdom
    Kidney Int 54:1429-36. 1998
  3. ncbi The cellular basis of albuminuria
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Clin Sci (Lond) 107:533-8. 2004
  4. ncbi What has the immune system got against the glomerular podocyte?
    P W Mathieson
    University of Bristol, Southmead Hospital, Bristol, UK
    Clin Exp Immunol 134:1-5. 2003
  5. ncbi Recurrence of IgM nephropathy in a renal allograft
    Andrew H J Salmon
    Academic Renal Unit, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK
    Nephrol Dial Transplant 19:2650-2. 2004
  6. ncbi Glomerulonephritis: is it worth worrying about?
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol
    Clin Med 5:264-6. 2005
  7. ncbi Glomerulonephritis in the tropics: who are the culprits?
    Peter W Mathieson
    Department of Clinical Science at North Bristol, University of Bristol, United Kingdom
    Ethn Dis 16:S2-52-5. 2006
  8. ncbi The podocyte as a target for therapies--new and old
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Nat Rev Nephrol 8:52-6. 2012
  9. ncbi Immune dysregulation in minimal change nephropathy
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Nephrol Dial Transplant 18:vi26-9. 2003
  10. ncbi Glomerulonephritis
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol, BS10 5NB, UK
    Semin Immunopathol 29:315-6. 2007

Collaborators

Detail Information

Publications48

  1. ncbi How much VEGF do you need?
    Peter W Mathieson
    J Am Soc Nephrol 17:602-3. 2006
  2. ncbi Is complement a target for therapy in renal disease?
    P W Mathieson
    Academic Renal Unit, University of Bristol, Bristol, England, United Kingdom
    Kidney Int 54:1429-36. 1998
    ..Much of the drive for the development of these therapies comes from the field of xenotransplantation, but these forms of therapy should also be tested in various primary renal diseases...
  3. ncbi The cellular basis of albuminuria
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Clin Sci (Lond) 107:533-8. 2004
    ..This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states and to suggest a possible explanation for the link between albuminuria and insulin resistance...
  4. ncbi What has the immune system got against the glomerular podocyte?
    P W Mathieson
    University of Bristol, Southmead Hospital, Bristol, UK
    Clin Exp Immunol 134:1-5. 2003
  5. ncbi Recurrence of IgM nephropathy in a renal allograft
    Andrew H J Salmon
    Academic Renal Unit, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK
    Nephrol Dial Transplant 19:2650-2. 2004
  6. ncbi Glomerulonephritis: is it worth worrying about?
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol
    Clin Med 5:264-6. 2005
    ..The importance of urinary abnormalities, particularly proteinuria (even if aysmptomatic and only detected on routine screening) is emphasised. Earlier recognition of GN will improve patient outcomes...
  7. ncbi Glomerulonephritis in the tropics: who are the culprits?
    Peter W Mathieson
    Department of Clinical Science at North Bristol, University of Bristol, United Kingdom
    Ethn Dis 16:S2-52-5. 2006
    ..This article highlights some general principles regarding glomerular disease in the developing world, illustrated by the author's experience in rural Uganda...
  8. ncbi The podocyte as a target for therapies--new and old
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Nat Rev Nephrol 8:52-6. 2012
    ..As well as being intellectually more satisfying, every reason exists to believe that patients of the future will benefit and that the scourge of progressive kidney disease will be more effectively tackled...
  9. ncbi Immune dysregulation in minimal change nephropathy
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Nephrol Dial Transplant 18:vi26-9. 2003
    ....
  10. ncbi Glomerulonephritis
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol, BS10 5NB, UK
    Semin Immunopathol 29:315-6. 2007
  11. ncbi Minimal change nephropathy and focal segmental glomerulosclerosis
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Bristol, UK
    Semin Immunopathol 29:415-26. 2007
    ..Future improvements in the understanding of these diseases and in our ability to successfully treat them can be confidently expected as a result of rapid advances in the study of podocyte biology in health and disease...
  12. ncbi Update on the podocyte
    Peter W Mathieson
    Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Curr Opin Nephrol Hypertens 18:206-11. 2009
    ..This article will review recent advances in understanding the complex biology, structure and function of the podocyte and the related clinical implications...
  13. ncbi Fat cell loss and mesangiocapillary glomerulonephritis: chicken, egg or both?
    Peter W Mathieson
    Academic Renal Unit, University of Bristol, Bristol, UK
    Nephron Clin Pract 96:c33-4. 2004
  14. ncbi Effects of type 2 cytokines on glomerular epithelial cells
    R G Parry
    Academic Renal Unit, Southmead Hospital, Bristol, UK
    Exp Nephrol 9:275-83. 2001
    ..These effects were not explained by effects on proliferation. Our data provide evidence that GECs express receptors for type 2 cytokines and that these cytokines can act directly on GECs, to decrease VEGF production...
  15. ncbi Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs
    S E Cross
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    Diabetologia 50:1423-32. 2007
    ..This study investigates the survival-promoting activities of VEGF in human islets and the effects of rapamycin on islet viability...
  16. ncbi Direct effects of dexamethasone on human podocytes
    C-Y Xing
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Kidney Int 70:1038-45. 2006
    ..These potent direct effects on podocytes illustrate a novel mode of action of glucocorticoids and suggest potential new therapeutic strategies for glomerular disease...
  17. ncbi High glucose causes dysfunction of the human glomerular endothelial glycocalyx
    A Singh
    Academic Renal Unit, Learning and Research Bldg, Clinical Sciences North Bristol, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Am J Physiol Renal Physiol 300:F40-8. 2011
    ....
  18. ncbi Expression of neuropilin-1 by human glomerular epithelial cells in vitro and in vivo
    S J Harper
    Academic Renal Unit, University of Bristol, Southmead Hospital, Westbury on Trym, Bristol B10 5NB, U K
    Clin Sci (Lond) 101:439-46. 2001
    ..Functional studies will be required to address the potential significance of this finding in terms of an autocrine loop or VEGF sequestration...
  19. ncbi Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF
    S C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    Kidney Int 69:1633-40. 2006
    ..They express fenestrations which are upregulated in response to VEGF. These cells are a unique resource for further study of GEnC and their roles in glomerular filtration, glomerular disease, and response to glomerular injury...
  20. ncbi Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1
    R Lennon
    Academic and Children s Renal Unit, Paul O Gorman Lifeline Centre, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 52:1944-52. 2009
    ..In this study we investigated the functional and molecular effects of the PPARgamma agonist rosiglitazone on human podocytes...
  21. ncbi Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse
    R Ravanan
    Department of Clinical Sciences at North Bristol, Bristol University, Bristol, UK
    Clin Exp Immunol 148:368-72. 2007
    ..Inhalation of GAD-derived peptides induces an immunoregulatory response that protects against recurrent autoimmune, but not alloimmune responses in the NOD mouse...
  22. ncbi Impact of diabetes on haemoglobin levels in renal disease
    R Ravanan
    Academic Renal Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 50:26-31. 2007
    ..To clarify this, we undertook a single centre, retrospective study to identify the impact of diabetes on anaemia associated with renal impairment...
  23. ncbi VEGF-C promotes survival in podocytes
    R R Foster
    Microvascular Research Laboratories, Department of Physiology, and Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 291:F196-207. 2006
    ..Together, these results suggest for the first time that VEGF-C acts in an autocrine manner in cultured podocytes to promote survival, although the receptor or receptor complex activated has yet to be elucidated...
  24. ncbi Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant
    C Whittle
    Academic Renal Unit, University of Bristol, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, U K
    Clin Sci (Lond) 97:303-12. 1999
    ..The physiological importance of VEGF(148) remains to be confirmed...
  25. ncbi Nephrin is critical for the action of insulin on human glomerular podocytes
    Richard J M Coward
    AcademicChildren s Renal Unit, University of Bristol, Bristol, UK
    Diabetes 56:1127-35. 2007
    ..This work demonstrates a previously unsuspected role of nephrin in vesicular docking and insulin responsiveness of podocytes...
  26. ncbi Glomerular endothelial glycocalyx constitutes a barrier to protein permeability
    Anurag Singh
    Academic Renal Unit, Southmead Hospital, Paul O Gorman Lifeline Centre, Clinical Sciences at North Bristol, University of Bristol, Bristol, UK
    J Am Soc Nephrol 18:2885-93. 2007
    ..These results suggest an important role for this glycocalyx in the restriction of glomerular protein passage in vivo and suggest ways in which human heparanase levels may be linked to proteinuria in clinical disease...
  27. ncbi Interferon-beta reduces proteinuria in experimental glomerulonephritis
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 18:2875-84. 2007
    ..These data indicate that IFN-beta may have potential as a therapeutic agent in proteinuric renal disease...
  28. ncbi A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    Moin A Saleem
    Children s Renal Unit and Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK
    J Am Soc Nephrol 13:630-8. 2002
    ..In conclusion, the development of this cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease...
  29. ncbi Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 13:544-50. 2002
    ....
  30. ncbi Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy
    Vadim K Pedchenko
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2372, USA
    Diabetes 54:2952-60. 2005
    ..This mechanism may contribute to the development of diabetic nephropathy...
  31. ncbi Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes
    Rachel Lennon
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom BS10 5NB
    J Am Soc Nephrol 19:2140-9. 2008
    ..In summary, active hemopexin causes nephrin-dependent remodeling of podocytes and affects permeability of the glomerular filtration barrier by degrading the glycocalyx...
  32. ncbi Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium
    Rebecca R Foster
    Academic Renal Unit, Southmead Hospital, Bristol, UK
    Am J Pathol 173:938-48. 2008
    ..These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A...
  33. ncbi Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 15:566-74. 2004
    ....
  34. ncbi A novel renal perspective of preeclampsia: a look from the podocyte
    Daniel E Henao
    Nephrol Dial Transplant 22:1477. 2007
  35. ncbi Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 288:F48-57. 2005
    ..However, the involvement of AKT in this survival response in normal human podocytes is not clear...
  36. ncbi Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein
    Tai Gen Cui
    Microvascula Research Laboratories, Dept of Physiology, Preclinical Veterinary School, Univ of Bristol, Southwell St, Bristol BS2 8EJ, UK
    Am J Physiol Renal Physiol 286:F767-73. 2004
    ....
  37. ncbi Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    Rebecca R Foster
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, Preclinical Veterinary School, United Kingdom
    Am J Physiol Renal Physiol 284:F1263-73. 2003
    ..These results indicate that one of the functions of VEGF secreted from podocytes may be to act as an autocrine factor on calcium homeostasis and cell survival...
  38. ncbi Angiopoietins: microvascular modulators with potential roles in glomerular pathophysiology
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    J Nephrol 16:168-78. 2003
    ..Manipulation of angiopoietins has a wide range of potential therapeutic applications from inhibition of diabetic retinal neovascularisation to promotion of glomerular repair...
  39. ncbi Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor
    Clemens D Cohen
    Medizinische Poliklinik, Ludwig Maximilians University, Pettenkoferstrasse 8a, Munich, 80336, Germany
    J Am Soc Nephrol 16:1958-65. 2005
    ..SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function...
  40. ncbi Cytokine polymorphisms and nephrotic syndrome
    Peter W Mathieson
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol BS10 5NB, UK
    Clin Sci (Lond) 102:513-4. 2002
  41. ncbi Nephrin sends us signals
    Peter W Mathieson
    Kidney Int 64:756-7. 2003
  42. ncbi Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration
    Michael J Morton
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    J Am Soc Nephrol 15:2981-7. 2004
    ..By implication, these results suggest that podocytes may be able to respond to changes in the glomerular capillary pressure and modulate the GFR...
  43. ncbi Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes
    Richard J M Coward
    Academic and Children s Renal Unit, Southmead Hospital, University of Bristol, Bristol, UK
    J Am Soc Nephrol 16:629-37. 2005
    ..This work demonstrates that nephrotic plasma seems to be deficient in factors that act via the podocyte SD complex, which are essential in maintaining its physiologic function...
  44. ncbi Podocyte-specific gene mutations are coming of age
    Peter W Mathieson
    J Am Soc Nephrol 19:190-1. 2008
  45. ncbi The human glomerular podocyte is a novel target for insulin action
    Richard J M Coward
    Academic and Children's Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK BS10 5NB
    Diabetes 54:3095-102. 2005
    ..Insulin responsiveness in this key structural component of the glomerular filtration barrier may have central relevance for understanding of diabetic nephropathy and for the association of albuminuria with states of insulin resistance...
  46. ncbi Effector mechanisms in murine allograft rejection: comparison of skin and heart grafts in fully allogeneic and minor histocompatibility antigen-mismatched strain combinations
    Abdel-Rahman Youssef
    Academic Renal Unit, Southmead Hospital, University of Bristol, Bristol BS10 5NB, UK
    Transpl Int 15:302-9. 2002
    ..This finding has implications in the design of new immunosuppressive strategies for clinical transplantation...
  47. ncbi Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation
    Moin A Saleem
    Children s Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    Am J Pathol 161:1459-66. 2002
    ..We demonstrate an intimate relationship between nephrin podocin and filamentous actin, and reason that disruption of nephrin/podocin could be a final common pathway leading to foot process effacement in proteinuric diseases...
  48. ncbi Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy
    Kar Neng Lai
    Dept of Medicine, Rm 411, Professorial Block, Queen Mary Hospital, Univ of Hong Kong, Hong Kong
    Am J Physiol Renal Physiol 294:F945-55. 2008
    ....