R A Malik

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation in patients with type 1 diabetes
    Sanjay Mehra
    Transplant Unit, Manchester Royal Infirmary, Manchester, UK
    Diabetes Care 30:2608-12. 2007
  2. ncbi Ameliorating human diabetic neuropathy: lessons from implanting hematopoietic mononuclear cells
    R A Malik
    Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, UK
    Exp Neurol 201:7-14. 2006
  3. ncbi Current and future strategies for the management of diabetic neuropathy
    Rayaz A Malik
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Treat Endocrinol 2:389-400. 2003
  4. ncbi Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Diabetologia 46:683-8. 2003
  5. ncbi Sural nerve pathology in diabetic patients with minimal but progressive neuropathy
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Diabetologia 48:578-85. 2005
  6. ncbi Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology
    R A Malik
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, UK
    Acta Neuropathol 101:367-74. 2001
  7. ncbi The Neuropad test: a visual indicator test for human diabetic neuropathy
    C Quattrini
    Division of Cardiovascular Medicine, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK
    Diabetologia 51:1046-50. 2008
  8. ncbi Increased Langerhan cell density and corneal nerve damage in diabetic patients: role of immune mechanisms in human diabetic neuropathy
    M Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, M13 9NT, UK
    Cont Lens Anterior Eye 34:7-11. 2011
  9. ncbi Nerve pathology in the type 1 diabetic dog: effects of treatment with sulindac
    D Walker
    Department of Medicine, Manchester Royal Infirmary, UK
    J Peripher Nerv Syst 6:219-26. 2001
  10. ncbi Offloading diabetic foot wounds using the scotchcast boot: a retrospective study
    E Ann Knowles
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Ostomy Wound Manage 48:50-3. 2002

Collaborators

Detail Information

Publications34

  1. ncbi Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation in patients with type 1 diabetes
    Sanjay Mehra
    Transplant Unit, Manchester Royal Infirmary, Manchester, UK
    Diabetes Care 30:2608-12. 2007
    ..We have used it to assess the neurological benefits of pancreas transplantation in type 1 diabetic patients...
  2. ncbi Ameliorating human diabetic neuropathy: lessons from implanting hematopoietic mononuclear cells
    R A Malik
    Division of Cardiovascular and Endocrine Sciences, University of Manchester, Manchester, UK
    Exp Neurol 201:7-14. 2006
  3. ncbi Current and future strategies for the management of diabetic neuropathy
    Rayaz A Malik
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Treat Endocrinol 2:389-400. 2003
    ..However, the antioxidant alpha-lipoic acid, as well as compounds which correct vascular dysfunction and hence neuropathy, such as ACE inhibitors and protein kinase C-beta inhibitors, have demonstrated more success...
  4. ncbi Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Diabetologia 46:683-8. 2003
    ..The aim of this study was to define the ability of this technique to quantify the extent of degeneration and regeneration of corneal nerve fibres in diabetic patients with increasing neuropathic severity...
  5. ncbi Sural nerve pathology in diabetic patients with minimal but progressive neuropathy
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Diabetologia 48:578-85. 2005
    ..The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy...
  6. ncbi Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology
    R A Malik
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, UK
    Acta Neuropathol 101:367-74. 2001
    ..02). Neurophysiology, quantitative sensory testing and nerve fibre pathology failed to differentiate diabetic patients with painful and painless neuropathy and failed to correlate with any measure of unmyelinated fibre pathology...
  7. ncbi The Neuropad test: a visual indicator test for human diabetic neuropathy
    C Quattrini
    Division of Cardiovascular Medicine, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK
    Diabetologia 51:1046-50. 2008
    ..It uses a colour change to define the integrity of skin sympathetic cholinergic innervation. We compared the results of Neuropad assessment in the foot with established measures of somatic and autonomic neuropathy...
  8. ncbi Increased Langerhan cell density and corneal nerve damage in diabetic patients: role of immune mechanisms in human diabetic neuropathy
    M Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, M13 9NT, UK
    Cont Lens Anterior Eye 34:7-11. 2011
    ..We employed in vivo corneal confocal microscopy (CCM) to quantify the presence and density of Langerhans cells (LCs) in relation to the extent of corneal nerve damage in Bowman's layer of the cornea in diabetic patients...
  9. ncbi Nerve pathology in the type 1 diabetic dog: effects of treatment with sulindac
    D Walker
    Department of Medicine, Manchester Royal Infirmary, UK
    J Peripher Nerv Syst 6:219-26. 2001
    ..We conclude that the type 1 diabetic dog demonstrates minor structural abnormalities in the nerve fibers and endoneurial capillaries of the sciatic nerve, and treatment with sulindac ameliorates some but not all of these abnormalities...
  10. ncbi Offloading diabetic foot wounds using the scotchcast boot: a retrospective study
    E Ann Knowles
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Ostomy Wound Manage 48:50-3. 2002
    ....
  11. ncbi Focal and multifocal neuropathies
    Rayaz A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Curr Diab Rep 2:489-94. 2002
    ..Because of their relatively infrequent occurrence, treatment is not evidence based...
  12. ncbi Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Manchester, M13 9PT, UK
    J Cell Mol Med 9:692-7. 2005
    ..Further studies are required to determine whether circulating CD105 levels could serve as a surrogate marker for early stage retinopathy and for monitoring disease progression...
  13. ncbi Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK
    S M Beard
    RTI Health Solutions, Manchester, UK
    Curr Med Res Opin 24:385-99. 2008
    ..The objective of this analysis was to evaluate the cost-effectiveness of duloxetine when considered as an additional treatment option for UK-based patients suffering from diabetic peripheral neuropathic pain...
  14. ncbi No morbidity-mortality. Commentary
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Diabet Med 19:7-8. 2002
  15. ncbi Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U.K
    Diabetes Care 28:956-62. 2005
  16. ncbi Explanations for the lower rates of diabetic neuropathy in Indian Asians versus Europeans
    Caroline A Abbott
    Cardiovascular Research Group, School of Biomedicine, University of Manchester, Manchester, UK
    Diabetes Care 33:1325-30. 2010
    ..K., possibly due to less neuropathy. We therefore compared signs, symptoms, and objective quantitative measures of diabetic neuropathy and their risk factors in Indian Asians and Europeans...
  17. ncbi Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy
    Cristian Quattrini
    Division of Cardiovascular Medicine, University of Manchester and Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester, UK
    Diabetes Care 31:140-5. 2008
    ....
  18. ncbi Surrogate markers of small fiber damage in human diabetic neuropathy
    Cristian Quattrini
    Division of Cardiovascular Medicine, University of Manchester, Manchester Diabetes Centre and Manchester Royal Infirmary, Manchester, UK
    Diabetes 56:2148-54. 2007
    ..This may make it an ideal technique to accurately diagnose and assess progression of human diabetic neuropathy...
  19. ncbi Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes
    Mitra Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, M13 9NT, UK
    Diabetes Care 30:1895-7. 2007
  20. ncbi Pathophysiology and treatment of painful diabetic neuropathy
    Mitra Tavakoli
    Division of Cardiovascular Medicine, University of Manchester, Manchester, UK
    Curr Pain Headache Rep 12:192-7. 2008
    ..We provide an update on the pathogenesis, diagnosis, and treatment of PDN...
  21. ncbi Management of painful diabetic neuropathy
    Mitra Tavakoli
    University of Manchester and Manchester Royal Infirmary, Division of Cardiovascular Medicine, Manchester, UK
    Expert Opin Pharmacother 9:2969-78. 2008
    ..Furthermore, a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. This review provides an update on the assessment and treatment of painful diabetic neuropathy...
  22. ncbi Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy
    Mitra Tavakoli
    Division of Cardiovascular Medicine, Central Manchester Foundation Trust and University of Manchester, Manchester, M13 9NT, UK
    Exp Neurol 223:245-50. 2010
    ..Corneal confocal microscopy provides a sensitive non-invasive means to detect small nerve fibre damage in patients with ISFN and metabolic abnormalities do not relate to nerve damage...
  23. ncbi Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy
    Moaz Mojaddidi
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Curr Diab Rep 5:417-22. 2005
    ....
  24. ncbi Impaired skin microvascular reactivity in painful diabetic neuropathy
    Cristian Quattrini
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Diabetes Care 30:655-9. 2007
    ....
  25. ncbi Corneal nerve tortuosity in diabetic patients with neuropathy
    Panagiotis Kallinikos
    Eurolens Research, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, United Kingdom
    Invest Ophthalmol Vis Sci 45:418-22. 2004
    ..This morphologic abnormality relates to the severity of somatic neuropathy and may reflect an alteration in the degree of degeneration and regeneration in diabetes...
  26. ncbi Neurovascular factors in wound healing in the foot skin of type 2 diabetic subjects
    Singhan T M Krishnan
    Diabetes Centre, Ipswich Hospital, Ipswich, UK
    Diabetes Care 30:3058-62. 2007
    ..In this study, we quantified the rate of wound healing in relation to skin neurovascular function and structure following a dorsal foot skin biopsy in type 2 diabetes...
  27. ncbi Early detection of diabetic peripheral neuropathy with corneal confocal microscopy
    Parwez Hossain
    University of Southampton, Southampton Eye Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Lancet 366:1340-3. 2005
  28. ncbi Diabetic somatic neuropathies
    Andrew J M Boulton
    Division of Endocrinology, University of Miami School of Medicine, P.O. Box 016960 (D-110, Miami, Florida, USA
    Diabetes Care 27:1458-86. 2004
  29. ncbi Neuropathy in diabetes: not a knee-jerk diagnosis
    Lee C Rogers
    Amputation Prevention Center, Broadlawns Medical Center, Des Moines, IA 50314, USA
    J Am Podiatr Med Assoc 98:322-5. 2008
    ..This case emphasizes the importance of considering alternative, potentially treatable, causes of peripheral neuropathy in patients with diabetes...
  30. ncbi Technique of the sural nerve biopsy
    Nicholas J Bevilacqua
    Center for Lower Extremity Ambulatory Research CLEAR, Department of Surgery, Dr William M Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, IL, USA
    J Foot Ankle Surg 46:139-42. 2007
    ..We review the usefulness of this procedure, describe the technique, and discuss the potential complications...
  31. ncbi Malignant melanoma misdiagnosed as a diabetic foot ulcer
    Lee C Rogers
    Diabetes Care 30:444-5. 2007
  32. ncbi Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus
    Rayaz A Malik
    Cardiovascular Research Group, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Hypertension 45:264-9. 2005
    ..These results demonstrate that even brief treatment with angiotensin II receptor blockade is associated with a significant improvement in resistance vessel endothelial function...
  33. ncbi Diabetic cardiomyopathy: mechanisms, diagnosis and treatment
    Sajad A Hayat
    Department of Cardiology, Northwick Park Hospital, Watford Road, Harrow HAI 3UJ, UK
    Clin Sci (Lond) 107:539-57. 2004
    ....
  34. ncbi Glycaemic control in south Asian patients during feasting and fasting
    Omar Asghar
    Division of Cardiovascular and Endocrine Science, Manchester Royal Infirmary University of Manchester, Manchester
    Br J Hosp Med (Lond) 67:523-6. 2006