Research Topics
| George T MacfarlaneSummaryAffiliation: University of Dundee Country: UK Publications
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Detail Information
Publications
Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture systemSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee Medical School, Level 6, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Appl Environ Microbiol 71:7483-92. 2005..Intestinal bacterial populations growing on mucin surfaces were shown to be phylogenetically and metabolically distinct from their planktonic counterparts...- Probiotics, infection and immunityGeorge T Macfarlane
Department of Molecular and Cellular Pathology, University of Dundee, UK
Curr Opin Infect Dis 15:501-6. 2002..This review summarizes the most recent contributions to this rapidly developing area... - Acquisition, evolution and maintenance of the normal gut microbiotaG T Macfarlane
University of Dundee, Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee, UK
Dig Dis 27:90-8. 2009..Increased antibiotic use in older people and simply going into hospital have been shown to change bacterial community structure in the colonic microbiota, although the metabolic significance of this is unclear... - The gut microbiota in inflammatory bowel diseaseG T Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Curr Pharm Des 15:1528-36. 2009.... - Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebioticsG T Macfarlane
Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
J Appl Microbiol 104:305-44. 2008..In many instances, prebiotics seem to be more effective when used as part of a synbiotic combination... - Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gutGeorge T Macfarlane
Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
Curr Opin Biotechnol 18:156-62. 2007..Recent developments using these systems have enabled modelling of surface colonisation and biofilm development, a hitherto neglected area of study... - Mucosa-associated bacterial diversity in relation to human terminal ileum and colonic biopsy samplesShakil Ahmed
Dundee University Gut Group, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Appl Environ Microbiol 73:7435-42. 2007..0004) and Faecalibacterium prausnitzii (P = 0.001) were dominant in the ascending and descending colon. Site-specific colonization in the gastrointestinal tract may be contributory in the etiology of some diseases of the large intestine... - Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analysesMark J Hopkins
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, UK
FEMS Microbiol Ecol 54:77-85. 2005..Both methodologies indicated increased bifidobacteria in breast-fed babies, and higher levels of desulfovibrios in bottle-fed children... - Effect of pH on an in vitro model of gastric microbiota in enteral nutrition patientsGraeme A O'May
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Appl Environ Microbiol 71:4777-83. 2005.... - Composition and metabolic activities of bacterial biofilms colonizing food residues in the human gutSandra Macfarlane
Gut Group, University of Dundee, Level 6, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
Appl Environ Microbiol 72:6204-11. 2006..Acetate was the principal fermentation product formed by biofilm bacteria, whereas higher levels of butyrate were produced by nonadherent populations, showing that the two communities were metabolically distinct... - Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteriaSabine Bartosch
Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Clin Infect Dis 40:28-37. 2005.... - Bacteria, colonic fermentation, and gastrointestinal healthGeorge T Macfarlane
University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
J AOAC Int 95:50-60. 2012..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel... - Degradation of cross-linked and non-cross-linked arabinoxylans by the intestinal microbiota in childrenMark J Hopkins
MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Appl Environ Microbiol 69:6354-60. 2003..In conclusion, in this study we found that the effects of AX and AXF on the microbial ecology and metabolism of intestinal microbiotas are similar in children and adults... - Studies on the effect of system retention time on bacterial populations colonizing a three-stage continuous culture model of the human large gut using FISH techniquesMatthew W Child
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
FEMS Microbiol Ecol 55:299-310. 2006.... - Bacterial translocation in cirrhosis is not caused by an abnormal small bowel gut microbiotaHelen Steed
Dundee University Gut Group, Ninewells Hospital and Medical School, UK
FEMS Immunol Med Microbiol 63:346-54. 2011.... - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjectsEmma J Woodmansey
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Appl Environ Microbiol 70:6113-22. 2004..Other differences in the intestinal ecosystem in elderly subjects were observed, with alterations in the dominant clostridial species in combination with greater numbers of facultative anaerobes... - Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitisSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, United Kingdom
Clin Infect Dis 38:1690-9. 2004..Interindividual variations in mucosal biofilms made it difficult to assign a role for specific bacteria in UC etiology. However, differences in bifidobacteria and peptostreptococci may implicate these organisms in this disease... - Regulation of short-chain fatty acid productionSandra Macfarlane
University of Dundee, MRC Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Proc Nutr Soc 62:67-72. 2003..In the latter organism acetate and succinate are the major fermentation products when substrate is abundant, whereas succinate is decarboxylated to produce propionate when C and energy sources are limiting... - Intestinal bacteria and inflammatory bowel diseaseSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
Crit Rev Clin Lab Sci 46:25-54. 2009.... - Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteriaElizabeth Furrie
Ninewells Hospital Medical School, University of Dundee, Dundee, UK
Immunology 115:565-74. 2005..In contrast, mature columnar epithelium is able to respond to viral pathogens, which are not part of the normal gut commensal microbiota... - Effect of a synbiotic on microbial community structure in a continuous culture model of the gastric microbiota in enteral nutrition patientsAileen R Smith
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
FEMS Microbiol Ecol 80:135-45. 2012..These results indicate that the use of a synbiotic has the potential to reduce pathogen colonization on PEG tube surfaces in vivo, thereby reducing the incidence of biofilm-related infectious complications... - Bacterial diversity in the human gutSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, United Kingdom
Adv Appl Microbiol 54:261-89. 2004 - Adherence and cytokine induction in Caco-2 cells by bacterial populations from a three-stage continuous-culture model of the large intestineBahram Bahrami
Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Appl Environ Microbiol 77:2934-42. 2011..This study demonstrates that environmental determinants regulate the adherence properties of intestinal bacteria and their abilities to regulate cytokine synthesis... - Prebiotics, synbiotics and inflammatory bowel diseaseHelen Steed
Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
Mol Nutr Food Res 52:898-905. 2008..More work is needed to understand the effects of prebiotics and synbiotics on microbial communities in the gut, and their interactions with the host's immune system... - Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiotaSabine Bartosch
MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Appl Environ Microbiol 70:3575-81. 2004.... - Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagusSandra Macfarlane
Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
Clin Infect Dis 45:29-38. 2007..The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE... - Nondigestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitroMark J Hopkins
Department of Molecular and Cellular Pathology, University of Dundee, United Kingdom
Appl Environ Microbiol 69:1920-7. 2003..In the absence of clindamycin, NDO enhanced colonization resistance against C. difficile, although this could not be attributed to bifidobacterium-induced inhibitory phenomena... - Effect of pH and antibiotics on microbial overgrowth in the stomachs and duodena of patients undergoing percutaneous endoscopic gastrostomy feedingGraeme A O'May
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
J Clin Microbiol 43:3059-65. 2005..were isolated only from antibiotic-treated patients, despite the sensitivities of the bacteria to the agents used. Antibiotic treatment had no effect on the incidence of infection or the length of hospital stay in these patients... - Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebioticsGeorge T Macfarlane
Microbiology and Gut Biology Group, Ninewells Hospital Medical School, University of Dundee, UK
J Clin Gastroenterol 45:S120-7. 2011..Many of these phenomena can be linked to their digestion and SCFA production by bacteria in the large gut... - Lactobacillus gasseri Gasser AM63(T) degrades oxalate in a multistage continuous culture simulator of the human colonic microbiotaThokozile R Lewanika
Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa
FEMS Microbiol Ecol 61:110-20. 2007..Oxalate degradation was initiated in the first stage of the CCS, corresponding to the proximal colon, suggesting that this organism may have potential therapeutic use in managing oxalate kidney stone disease in humans...