Research Topics
Genomes and Genes
| Edward D LoweSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenaseEdward D Lowe
Laboratory of Molecular Biophysics, University of Oxford, Rex Richards Building, Oxford OX1 3QU, UK
J Med Chem 51:4482-7. 2008..These observations provide an explanation for both the specificity and affinity of daidzin (IC50 =80 nM) and the affinity of analogues with different substituents at the glucosyl position...- Structures of the Dsk2 UBL and UBA domains and their complexEdward D Lowe
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England
Acta Crystallogr D Biol Crystallogr 62:177-88. 2006..A model is discussed in which two or more Dsk2 UBA molecules may selectively bind to K48-linked polyubiquitin... - Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12Christiane Riedinger
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
J Biol Chem 285:33992-4003. 2010..This is the first observation of a UIM binding other than a Ub fold and suggests that SpRpn12 could modulate the activity of SpRpn10 as a proteasomal Ub receptor... - Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferaseElizabeth Fullam
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
J Mol Biol 375:178-91. 2008..It also suggests the cofactor-binding site as a unique subsite to target in drug design directed against NAT in mycobacteria... - The crystal structure of human CDK7 and its protein recognition propertiesGraziano Lolli
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Rex Richards Building, Oxford, OX1 3QU, United Kingdom
Structure 12:2067-79. 2004..The functional properties of the enzyme against CDK2 and CTD as substrates are characterized through kinase assays. Experiments confirm that CDK7 is not a substrate for kinase-associated phosphatase... - The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent rolesReiko Honda
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
EMBO J 24:452-63. 2005..The structural and kinetic results indicate no inherent substrate discrimination between pCDK2/cyclin E and pCDK2/cyclin A with model substrates... - The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complexKin Yip Cheng
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
EMBO J 22:5757-68. 2003..Most of these residues had been shown to be important for biological activity through mutational studies. The results provide an explanation for phospho-peptide recognition and create the basis for new functional studies... - The structure of an integrin/talin complex reveals the basis of inside-out signal transductionNicholas J Anthis
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
EMBO J 28:3623-32. 2009..These results show key structural features that explain the ability of talin to mediate inside-out TM signalling... - Structural analysis of the interactions between paxillin LD motifs and alpha-parvinSonja Lorenz
Laboratory of Molecular Biophysics, University of Oxford, Oxford OX1 3QU, United Kingdom
Structure 16:1521-31. 2008..Taken together, these results reveal an unusual degree of binding degeneracy in the paxillin/alpha-parvin system that may facilitate the assembly of dynamic signaling complexes in the cell... - Identification and structural analysis of type I collagen sites in complex with fibronectin fragmentsMichele C Erat
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
Proc Natl Acad Sci U S A 106:4195-200. 2009..We demonstrate, by kinetic unfolding experiments, that the triple-helical collagen state is destabilized by (8-9)FnI. This finding suggests a role for fibronectin in collagen proteolysis and tissue remodeling... - An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin bindingCamilla L Oxley
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
J Biol Chem 283:5420-6. 2008..This switch may represent an in vivo mechanism for control of integrin receptor activation. These results have implications for the control of integrin signaling by proteins containing phosphotyrosine binding domains... - Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferiFrank S Cordes
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
Acta Crystallogr D Biol Crystallogr 60:929-32. 2004..2 A resolution have been collected. The selenium substructure has been solved and initial phases have been refined to 3.0 A by density-modification methods. Model building and refinement are under way... - Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2Angela J Russell
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Bioorg Med Chem 17:905-18. 2009..1)H NMR studies on purified mouse Nat2 demonstrate that the inhibitors bind within the putative active site of the enzyme... - The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationSonja Baumli
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
EMBO J 27:1907-18. 2008..We show that CDK9/CycT1 autophosphorylates on Thr186 in the activation segment and three C-terminal phosphorylation sites. Autophosphorylation on all sites occurs in cis... - Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active siteAreej M Abuhammad
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
Protein Cell 1:384-92. 2010..From the mode of ligand binding, features of the binding pocket can be identified, which point to a novel mechanism for the acetylation reaction that results in a 3-methyltriazolo[3,4-a]phthalazine ring compound as product... - Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteinsSacha A Jensen
Department of Biochemistry, University of Oxford, Oxford, UK
Structure 17:759-68. 2009.... - How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramerClaire E Chivers
Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK
Biochem J 435:55-63. 2011..Understanding the structural features of this tenacious interaction may assist the design of even stronger affinity tags and inhibitors... - Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domainJean Francois Trempe
Laboratory of Molecular Biophysics, University of Oxford, Oxford, UK
EMBO J 24:3178-89. 2005..We therefore propose a mechanism for the recognition of K48-linked polyubiquitin chains by Mud1 in which diubiquitin units are specifically recognized by a single UBA domain... - Crystal structure of the potassium channel KirBac1.1 in the closed stateAnling Kuo
University of Oxford, Department of Biochemistry, Laboratory of Molecular Biophysics, South Parks Road, Oxford OX1 3QU, UK
Science 300:1922-6. 2003..This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway... - Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin AEdward D Lowe
Laboratory of Molecular Biophysics, University of Oxford, Rex Richards Building, Oxford OX1 3QU, UK
Biochemistry 41:15625-34. 2002..The observations have implications for the further identification of physiological substrates of CDK2/cyclin A and the design of specific inhibitors...