Laurence Loewe

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi The population genetics of mutations: good, bad and indifferent
    Laurence Loewe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:1153-67. 2010
  2. ncbi Computational models in systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, School of Biological Sciences, The University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh EH9 3JU, UK
    Genome Biol 9:328. 2008
  3. ncbi A framework for evolutionary systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, The University of Edinburgh, Edinburgh, Scotland, UK
    BMC Syst Biol 3:27. 2009
  4. ncbi On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
  5. ncbi Inferring the distribution of mutational effects on fitness in Drosophila
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Biol Lett 2:426-30. 2006
  6. ncbi Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010
  7. ncbi Background selection in single genes may explain patterns of codon bias
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 175:1381-93. 2007
  8. ncbi Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa)
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    BMC Evol Biol 8:88. 2008
  9. ncbi Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites
    Paul Hunt
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    BMC Genomics 11:499. 2010
  10. ncbi Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Genet Res 87:133-59. 2006

Detail Information

Publications11

  1. ncbi The population genetics of mutations: good, bad and indifferent
    Laurence Loewe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:1153-67. 2010
    ..important, why do we age, which genetic processes can generate new species or drive endangered species to extinction, and how should policy on levels of potentially harmful mutagens introduced into the environment by humans be determined?..
  2. ncbi Computational models in systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, School of Biological Sciences, The University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh EH9 3JU, UK
    Genome Biol 9:328. 2008
    ..A report of the 6th International Conference on Computational Methods in Systems Biology, Rostock, Germany, 12-15 October 2008...
  3. ncbi A framework for evolutionary systems biology
    Laurence Loewe
    Centre for Systems Biology at Edinburgh, The University of Edinburgh, Edinburgh, Scotland, UK
    BMC Syst Biol 3:27. 2009
    ..Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe small effects...
  4. ncbi On the potential for extinction by Muller's ratchet in Caenorhabditis elegans
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:125. 2008
    ..The potential for such a process to occur would inform our understanding of the time since the origin of self-fertilization in C. elegans history...
  5. ncbi Inferring the distribution of mutational effects on fitness in Drosophila
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Biol Lett 2:426-30. 2006
    ..Our results suggest that the majority of non-synonymous mutations in Drosophila are under effective purifying selection...
  6. ncbi Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010
    ..Overall, the results show that both purifying selection and positive selection on nonsynonymous mutations are pervasive...
  7. ncbi Background selection in single genes may explain patterns of codon bias
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 175:1381-93. 2007
    ..The model overpredicts the effects of background selection with large groups of nonrecombining genes, because it ignores Hill-Robertson interference among the mutations involved...
  8. ncbi Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa)
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    BMC Evol Biol 8:88. 2008
    ..However, no detailed quantification of the extent of this threat is available...
  9. ncbi Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites
    Paul Hunt
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    BMC Genomics 11:499. 2010
    ..Such genetic markers will further the investigation of resistance and its control in natural infections of the human malaria, P. falciparum...
  10. ncbi Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Genet Res 87:133-59. 2006
    ..Future work will have to explore which of these actually solves the paradox. Nonetheless, the results presented here provide yet another reason to minimize anthropogenic increase of mutation rates...
  11. ncbi Estimating selection on nonsynonymous mutations
    Laurence Loewe
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 172:1079-92. 2006
    ..We also describe a simple approximate method for estimating the harmonic mean selection coefficient from diversity data on a single species...