Research Topics
| A C LloydSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Distinct functions for ERKs?Alison C Lloyd
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
J Biol 5:13. 2006..Recent studies add complexity to this cascade by indicating that the two ERK kinases, ERK1 (p44ERK1) and ERK2 (p42ERK2), may have distinct functions...- Ras versus cyclin-dependent kinase inhibitorsA C Lloyd
MRC Laboratory for Molecular Cell Biology, University College London, London, UK
Curr Opin Genet Dev 8:43-8. 1998..In the absence of a negative growth signal from Ras, such as in most immortalised cell lines, Ras acts positively on the cell cycle. Insights have been made into the mechanisms by which Ras abrogates remaining cell-cycle controls... - Limits to lifespanAlison C Lloyd
Cancer Research Campaign, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
Nat Cell Biol 4:E25-7. 2002..Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential... - Lack of replicative senescence in normal rodent gliaN F Mathon
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
Science 291:872-5. 2001..These findings demonstrate that senescence is not an inevitable consequence of extended proliferation in culture... - Cooperating oncogenes converge to regulate cyclin/cdk complexesA C Lloyd
Imperial Cancer Research Fund ICRF, London, UK
Genes Dev 11:663-77. 1997..Thus, signaling by Raf and its cooperating partners converges at the regulation of cyclin/cdk complexes, with the cellular responses to Raf modulated by p53... - Lack of replicative senescence in cultured rat oligodendrocyte precursor cellsD G Tang
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
Science 291:868-71. 2001..Our findings suggest that some normal rodent precursor cells have an unlimited proliferative capacity if cultured in conditions that avoid both differentiation and the activation of checkpoint responses that arrest the cell cycle... - Cell senescence and cancerN F Mathon
Department of Biochemistry, University College London, UK
Nat Rev Cancer 1:203-13. 2001..In this review, we discuss the pathways of cell senescence, the mechanisms involved and the role that these pathways have in regulating the initiation and progression of cancer... - The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiationMarie C Harrisingh
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London, UK
EMBO J 23:3061-71. 2004..Our results suggest that the effects of Ras signalling on the differentiation state of Schwann cells may be important in the pathogenesis of these tumours... - Cell size regulation in mammalian cellsPedro Echave
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London, UK
Cell Cycle 6:218-24. 2007..This has profound effects on cell behaviour... - Hijacking the ERK signaling pathway: Mycobacterium leprae shuns MEK to drive the proliferation of infected Schwann cellsLuke A Noon
Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
Sci STKE 2005:pe52. 2005..In this Perspective, we discuss this important piece of work and highlight the noncanonical pathway used by M. leprae to induce proliferation... - Treating leprosy: an Erb-al remedy?Luke A Noon
MRC Laboratory for Molecular Cell Biology and the Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK
Trends Pharmacol Sci 28:103-5. 2007..These findings have relevance for the potential treatment of leprosy and they highlight parallels between the dedifferentiation signal in leprosy and that in nerve injury and cancer... - Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesisPedro Echave
MRC Laboratory for Molecular Cell Biology, The Cancer Institute, University College London, London, UK
J Cell Sci 122:4516-25. 2009..This separation of the pathways that drive mitochondrial biogenesis and cell growth provides a mechanism for the modulation of mitochondrial density according to the metabolic requirements of the cell... - Ras/Raf/ERK signalling and NF1Marie C Harrisingh
MRC Laboratory for Molecular Cell Biology and the Department of Biochemistry, University College London, Gower Street, London, UK
Cell Cycle 3:1255-8. 2004..We have found that Ras/Raf/ERK signalling can drive the de-differentiation of myelinated Schwann cells. In this review, we discuss how our results may contribute to the understanding of tumor formation in NF1 patients... - Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotypePhilip J Mitchell
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, London WC1E 6BT, United Kingdom
Mol Cell Biol 23:2530-42. 2003..We demonstrate here a role for p16(INK4A) in the loss of cell cycle controls required for tumorigenesis and show how accumulating genetic changes cooperate and contribute to the transformed phenotype... - EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sortingSimona Parrinello
MRC Laboratory for Molecular Cell Biology and the UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK
Cell 143:145-55. 2010..Our results identify a link between Ephs and Sox proteins, providing a mechanism by which progenitor cells can translate environmental cues to orchestrate the formation of new tissue... - Spontaneous human adult stem cell transformationDaniel Rubio
Department of Immunology and Oncology, , UAM Campus de Cantoblanco, Darwin, 3 E-28049 Madrid, Spain
Cancer Res 65:3035-9. 2005..Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential...