A P Leff

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Treatment of reading impairment after stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Curr Opin Neurol 21:644-8. 2008
  2. ncbi The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 132:3401-10. 2009
  3. ncbi Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, London, UK
    Cortex 45:517-26. 2009
  4. ncbi Structural anatomy of pure and hemianopic alexia
    A P Leff
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    J Neurol Neurosurg Psychiatry 77:1004-7. 2006
  5. ncbi The cortical dynamics of intelligible speech
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    J Neurosci 28:13209-15. 2008
  6. ncbi The functional anatomy of single-word reading in patients with hemianopic and pure alexia
    A P Leff
    MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London W12 0NN, UK
    Brain 124:510-21. 2001
  7. ncbi Changing meaning causes coupling changes within higher levels of the cortical hierarchy
    T M Schofield
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 106:11765-70. 2009
  8. ncbi Lesion sites that predict the ability to gesture how an object is used
    C J Price
    Wellcome Trust Centre for Neuro imaging, Institute of Neurology, University College London, UK
    Arch Ital Biol 148:243-58. 2010
  9. ncbi The planning and guiding of reading saccades: a repetitive transcranial magnetic stimulation study
    A P Leff
    Medical Research Council Cyclotron Unit and Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK
    Cereb Cortex 11:918-23. 2001
  10. ncbi Optokinetic therapy improves text reading in patients with hemianopic alexia: a controlled trial
    G A Spitzyna
    Department of Clinical Neurosciences, Royal Free Hospital and University College Medical School, London, UK
    Neurology 68:1922-30. 2007

Detail Information

Publications12

  1. ncbi Treatment of reading impairment after stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Curr Opin Neurol 21:644-8. 2008
    ..In this review, we focus on the classification of acquired alexia and the current theory and practice underlying the rehabilitation of this diverse set of disorders...
  2. ncbi The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 132:3401-10. 2009
    ..The method applied here will be particularly useful for modelling structure-function relationships within other complex cognitive domains...
  3. ncbi Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, London, UK
    Cortex 45:517-26. 2009
    ..Neural components of this pathway would be expected to respond to sudden, perhaps unexpected changes in speech signal that result in a change to narrative meaning...
  4. ncbi Structural anatomy of pure and hemianopic alexia
    A P Leff
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    J Neurol Neurosurg Psychiatry 77:1004-7. 2006
    ..Patients with pure alexia also often have a hemianopia but are more disabled, making frequent errors on individual words; they have sustained damage to a brain region that supports efficient word identification...
  5. ncbi The cortical dynamics of intelligible speech
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    J Neurosci 28:13209-15. 2008
    ..Task-related, directional effects can now be incorporated into models of speech comprehension...
  6. ncbi The functional anatomy of single-word reading in patients with hemianopic and pure alexia
    A P Leff
    MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London W12 0NN, UK
    Brain 124:510-21. 2001
    ..The relative contributions of pure and hemianopic alexia in individual patients needs to be assessed, as the latter has been shown to respond well to specific rehabilitation programmes...
  7. ncbi Changing meaning causes coupling changes within higher levels of the cortical hierarchy
    T M Schofield
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 106:11765-70. 2009
    ..e., a word). Furthermore, our lateralization results suggest left hemisphere specificity for the processing of phonological stimuli, regardless of their elemental (i.e., spectrotemporal) characteristics...
  8. ncbi Lesion sites that predict the ability to gesture how an object is used
    C J Price
    Wellcome Trust Centre for Neuro imaging, Institute of Neurology, University College London, UK
    Arch Ital Biol 148:243-58. 2010
    ..Our methods provide a framework for future studies aiming to predict the consequences of brain damage...
  9. ncbi The planning and guiding of reading saccades: a repetitive transcranial magnetic stimulation study
    A P Leff
    Medical Research Council Cyclotron Unit and Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK
    Cereb Cortex 11:918-23. 2001
    ..Our results are compatible with the hypotheses that the left PPC maintains reading saccades along a line of text while the right FEF is involved in the preparation of the motor plan for the scanpath at the start of each new line of text...
  10. ncbi Optokinetic therapy improves text reading in patients with hemianopic alexia: a controlled trial
    G A Spitzyna
    Department of Clinical Neurosciences, Royal Free Hospital and University College Medical School, London, UK
    Neurology 68:1922-30. 2007
    ....
  11. ncbi The role of the thalamus in amnesia: a tractography, high-resolution MRI and neuropsychological study
    L Cipolotti
    Department of Neuropsychology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Neuropsychologia 46:2745-58. 2008
    ..This finding raises the possibility that fractionation of familiarity and recollection to separate thalamic nuclei may not fully capture the role of thalamic sub-regions in memory function...
  12. ncbi "Bottom-up" and "top-down" effects on reading saccades: a case study
    N J Upton
    Department of Human Sciences, Brunel University, Uxbridge, Middlesex UB8 2HG, UK
    J Neurol Neurosurg Psychiatry 74:1423-8. 2003
    ..To investigate the role right foveal/parafoveal sparing plays in reading single words, word arrays, and eye movement patterns in a single case with an incongruous hemianopia...