Daniel Lamb

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi An antibody that blocks human T-cell leukemia virus type 1 six-helix-bundle formation in vitro identified by a novel assay for inhibitors of envelope function
    Antonis Mirsaliotis
    The Biomedical Research Centre, Ninewells Hospital and Medical School, The University, Dundee DD1 9SY, UK
    J Gen Virol 88:660-9. 2007
  2. ncbi Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope
    Daniel Lamb
    The Biomedical Research Centre, College of Medicine, Ninewells Hospital, The University, Dundee, DD1 9SY, Scotland, UK
    Retrovirology 5:70. 2008
  3. ncbi Nonhelical leash and alpha-helical structures determine the potency of a peptide antagonist of human T-cell leukemia virus entry
    Antonis Mirsaliotis
    The Biomedical Research Centre, Ninewells, Hospital and Medical School, The University, Dundee DD1 9SY, Scotland, United Kingdom
    J Virol 82:4965-73. 2008
  4. ncbi Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry
    Daniel Lamb
    Biomedical Research Centre, Ninewells Hospital and Medical School, The University, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 284:6575-84. 2009
  5. ncbi Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins
    Daniel Lamb
    The BioMedical Research Institute, College of Medicine, Ninewells Hospital, The University of Dundee, Dundee, UK
    PLoS Pathog 7:e1001268. 2011
  6. ncbi Conformation-specific antibodies targeting the trimer-of-hairpins motif of the human T-cell leukemia virus type 1 transmembrane glycoprotein recognize the viral envelope but fail to neutralize viral entry
    Antonis Mirsaliotis
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Virol 81:6019-31. 2007
  7. ncbi Resistance to neutralization by antibodies targeting the coiled coil of fusion-active envelope is a common feature of retroviruses
    Antonis Mirsaliotis
    Biomedical Research Centre, Ninewells Hospital and Medical School, The University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 282:36724-35. 2007

Collaborators

  • J M Woof
  • Antonis Mirsaliotis
  • David W Brighty
  • Kulpash Nurkiyanova
  • Chien-Wen S Kuo
  • Chien Wen S Kuo

Detail Information

Publications7

  1. ncbi An antibody that blocks human T-cell leukemia virus type 1 six-helix-bundle formation in vitro identified by a novel assay for inhibitors of envelope function
    Antonis Mirsaliotis
    The Biomedical Research Centre, Ninewells Hospital and Medical School, The University, Dundee DD1 9SY, UK
    J Gen Virol 88:660-9. 2007
    ..Moreover, the assay developed here will aid the search for therapeutic antibodies, peptides and small-molecule inhibitors targeting envelope and the HTLV-1 entry process...
  2. ncbi Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope
    Daniel Lamb
    The Biomedical Research Centre, College of Medicine, Ninewells Hospital, The University, Dundee, DD1 9SY, Scotland, UK
    Retrovirology 5:70. 2008
    ..For HTLV-1 and for several virus groups this process is sensitive to inhibition by peptides that mimic the C-terminal alpha-helical region of the trimer-of-hairpins...
  3. ncbi Nonhelical leash and alpha-helical structures determine the potency of a peptide antagonist of human T-cell leukemia virus entry
    Antonis Mirsaliotis
    The Biomedical Research Centre, Ninewells, Hospital and Medical School, The University, Dundee DD1 9SY, Scotland, United Kingdom
    J Virol 82:4965-73. 2008
    ..Finally, we propose that leash-like mimetic peptides may be of value as entry inhibitors for other clinically important viral infections...
  4. ncbi Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry
    Daniel Lamb
    Biomedical Research Centre, Ninewells Hospital and Medical School, The University, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 284:6575-84. 2009
    ..Such molecules may be attractive candidates for therapeutic intervention in human T cell leukemia virus type 1 infections...
  5. ncbi Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins
    Daniel Lamb
    The BioMedical Research Institute, College of Medicine, Ninewells Hospital, The University of Dundee, Dundee, UK
    PLoS Pathog 7:e1001268. 2011
    ....
  6. ncbi Conformation-specific antibodies targeting the trimer-of-hairpins motif of the human T-cell leukemia virus type 1 transmembrane glycoprotein recognize the viral envelope but fail to neutralize viral entry
    Antonis Mirsaliotis
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Virol 81:6019-31. 2007
    ....
  7. ncbi Resistance to neutralization by antibodies targeting the coiled coil of fusion-active envelope is a common feature of retroviruses
    Antonis Mirsaliotis
    Biomedical Research Centre, Ninewells Hospital and Medical School, The University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 282:36724-35. 2007
    ..These observations have significant implications for vaccine design...