Research Topics
Species | Julia C KnightSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1Julian C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Nat Genet 36:394-9. 2004..These findings provide a molecular model of how LTA expression may be genetically regulated by allele-specific recruitment of the transcriptional repressor ABF-1...- Resolving the variable genome and epigenome in human diseaseJ C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
J Intern Med 271:379-91. 2012.... - Understanding human genetic variation in the era of high-throughput sequencingJulian C Knight
Wellcome Trust Centre for Human Genetics at the University of Oxford, Oxford, UK
EMBO Rep 11:650-2. 2010.... - Genetics and the general physician: insights, applications and future challengesJ C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
QJM 102:757-72. 2009..There is also a need for a broader debate about the ethical implications of current advances in genetics for medicine and society... - Functional implications of genetic variation in non-coding DNA for disease susceptibility and gene regulationJulian C Knight
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
Clin Sci (Lond) 104:493-501. 2003..The strategic application of these functional approaches is discussed and illustrated by analysis of the role of genetic variation in the tumour necrosis factor promoter region in determining susceptibility to severe malaria... - Regulatory polymorphisms underlying complex disease traitsJulian C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
J Mol Med (Berl) 83:97-109. 2005.... - In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loadingJulian C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Nat Genet 33:469-75. 2003..The haploChIP method may be useful in high-throughput screening for common DNA polymorphisms that affect gene regulation in vivo... - Allele-specific gene expression uncoveredJulia C Knight
Wellcome Trust Centre for Human Genetics, Universit of Oxford, Oxfoed, UK
Trends Genet 20:113-6. 2004..These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly context specific... - A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolutionSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
Genome Res 20:1352-60. 2010..ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases... - The human Major Histocompatibility Complex as a paradigm in genomics researchClaire Vandiedonck
Wellcome Trust Centre for Human Genetics WTCHG, University of Oxford, Oxford, UK
Brief Funct Genomic Proteomic 8:379-94. 2009..This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics... - Multiple sclerosis and the major histocompatibility complexSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, UK
Curr Opin Neurol 22:219-25. 2009..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC)... - Analysis of allele-specific gene expressionJulian C Knight
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Methods Mol Biol 338:153-65. 2006..These include analysis of the relative allelic abundance of transcribed RNA and of transcription factor recruitment and Pol II loading by chromatin immunoprecipitation... - Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elementsJennifer M Taylor
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Nucleic Acids Res 36:4845-62. 2008.... - Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin DSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 5:e1000369. 2009..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention... - A common variant associated with dyslexia reduces expression of the KIAA0319 geneMegan Y Dennis
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
PLoS Genet 5:e1000436. 2009..Our study thus pinpoints a common variant as altering the function of a dyslexia candidate gene and provides an illustrative example of the strategic approach needed to dissect the molecular basis of complex genetic traits... - Leprosy and the adaptation of human toll-like receptor 1Sunny H Wong
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Pathog 6:e1000979. 2010..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases... - The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migrationSilvia Paracchini
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 15:1659-66. 2006..2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex... - HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibilityMichael J Chao
Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 105:13069-74. 2008....