Research Topics
| G E KassSummaryAffiliation: University of Surrey Country: UK Publications
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Detail Information
Publications
The role of apoptosis in acetaminophen-induced injuryGeorge E N Kass
School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom
Ann N Y Acad Sci 1010:557-9. 2003..In conclusion, AAP induces apoptosis in human hepatoblastoma HuH7 cells through mitochondrial cytochrome c release and caspase activation...- Calcium signaling and cytotoxicityG E Kass
School of Biological Sciences, University of Surrey, Guildford, United Kingdom
Environ Health Perspect 107:25-35. 1999..In contrast, under some conditions, Ca(2+) signals may be cytoprotective and antagonize the apoptotic machinery... - Role of mitochondria in drug-induced cholestatic injuryGeorge E N Kass
Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK
Clin Liver Dis 12:27-51, vii. 2008..This article discusses the role of mitochondria in drug-induced cholestatic injury to the liver. The role of mitochondria in the cellular adaptation against the toxic effects of bile acids is discussed also... - Mitochondrial involvement in drug-induced hepatic injuryGeorge E N Kass
School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
Chem Biol Interact 163:145-59. 2006..This paper reviews our current knowledge about how hepatotoxic drugs, whether direct acting or through induction of steatosis or cholestasis, target mitochondria and cause hepatic injury... - Induction of apoptosis by a novel copper-based anticancer compound, casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cellsA De Vizcaya-Ruiz
School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK
Toxicol In Vitro 14:1-5. 2000..In this work we show that the novel copper-based antineoplastic agent casiopeina II is highly active against murine and human cancer cell lines, including cell lines resistant to cisplatin... - Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infectionL O Roberts
School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK
J Gen Virol 81:1703-7. 2000..These data, and the fact that induction of apoptosis yields different eIF4GI cleavage fragments, indicate that caspases do not have a major role in the cleavage of eIF4GI during PV or FMDV infection... - Poliovirus induces an early impairment of mitochondrial function by inhibiting succinate dehydrogenase activityA Koundouris
School of Biological Sciences, University of Surrey, Guildford, Surrey, United Kingdom
Biochem Biophys Res Commun 271:610-4. 2000..This shows that mitochondrial function is profoundly altered during poliovirus infection and that this occurs primarily through inhibition of electron flow at complex II of the mitochondrial respiratory chain... - Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cellsPatricia Macanas-Pirard
School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
J Pharmacol Exp Ther 313:780-9. 2005..It is concluded that AAP-induced apoptosis involves the mitochondrial pathway of apoptosis that is mediated by GSK-3 and most likely initiated through an endoplasmic reticulum stress response... - Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspasesR A Jones
School of Biological Sciences, University of Surrey, Guildford, Surrey, United Kingdom
Biochem Biophys Res Commun 256:436-41. 1999..Furthermore, liver PARP was not cleaved by recombinant human caspase-3. It is concluded that PARP proteolysis cannot be used as a marker for hepatocyte apoptosis... - Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspasesHasan El-Hassan
School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
Toxicol Appl Pharmacol 191:118-29. 2003..However, as suggested by the lack of activation of the main execution caspases, apoptosis is not properly executed and degenerates into necrosis... - The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase CN S Yaacob
School of Biomedical and Life Sciences, University of Surrey, Surrey GU2 7XH, Guildford, UK
Toxicol Lett 125:133-41. 2001..The PKC signal transduction pathway contributes to the regulation of PPARalpha expression but does not influence the transcriptional activity of PPARalpha... - The mitochondrial pathway of apoptosis is triggered during feline calicivirus infectionAlessandro Natoni
School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
J Gen Virol 87:357-61. 2006..These results suggest that the mitochondrial pathway of apoptosis is triggered during FCV infection... - Human herpesvirus 1 protein US3 induces an inhibition of mitochondrial electron transportMohammad Derakhshan
School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
J Gen Virol 87:2155-9. 2006..The integrity of the electron-transport chain in HHV-1-infected cells was analysed further and the site of the block in electron transport was located between complexes II and III, a site previously shown to be affected by Poliovirus... - Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicityLucy M Elphick
Division of Biochemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK
Toxicol Appl Pharmacol 232:258-67. 2008..We conclude that oxidative L-glutamate toxicity in HT22 cells is mediated via calpain activation, whereas inhibition of caspases-8 and -9 may exacerbate L-glutamate-induced oxidative neuronal damage through increased oxidative stress...