Research Topics
| L JonesSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virusLouise Jones
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford, UK
Eur J Immunol 37:3393-403. 2007..In summary these data implicate persistent low-level or recurrent VZV antigen exposure in healthy immune donors and are compatible with a role for IE63-specific CD4+ T cells in the control of viral reactivation...- Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responsesL Jones
MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
Vaccine 27:7398-401. 2009.... - Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donorsG N Malavige
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Clin Exp Immunol 152:522-31. 2008..These data would be compatible with frequent exposure to replicative cycle antigens in healthy donors and are consistent with a role for gE-specific CD4+ T cells in the control of viral replication... - The role of skin-homing T cells in extrinsic atopic dermatitisS L Seneviratne
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford OX3 9DS
QJM 100:19-27. 2007..T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease... - Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cellsS L Seneviratne
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Clin Exp Dermatol 31:689-94. 2006..CONCLUSIONS: Analysis of levels of allergen-specific CD4+ T-cell production of IL-10 in relation to disease severity argues in favour of a role for IL-10 in the control of atopic dermatitis... - Frequencies of circulating allergen-specific T cells temporally associate with longitudinal changes in severity of cutaneous atopic diseaseT McPherson
Department of Dermatology, Churchill Hospital, Oxford, UK
Clin Exp Dermatol 35:786-8. 2010..01) with changes in disease severity. These findings support a role for allergen-specific T-cells in disease pathogenesis... - Immune evasion during varicella zoster virus infection of keratinocytesA P Black
MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
Clin Exp Dermatol 34:e941-4. 2009..Interference with IFN-alpha, TNF-alpha, IFN-gamma and TLR-3 signalling in keratinocytes by VZV may contribute to immune evasion of the adaptive immune response... - p53-specific CD8+ T-cell responses in individuals with cutaneous squamous cell carcinomaA P Black
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Br J Dermatol 153:987-91. 2005..CONCLUSIONS: Overall, these data suggest that p53 may represent a target for CD8+ T cells in a proportion of individuals with cutaneous SCC... - Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczemaT McPherson
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and NIHR Biomedical Research Centre, OX3 9DS, U K
Br J Dermatol 163:544-9. 2010..However, while epidermal dysfunction is an important factor in disease pathogenesis, it is unclear how such dysfunction interacts with immune responses to contribute to cutaneous and other inflammatory atopic disease... - Dietary questions as determinants of mortality: the OXCHECK experienceD Whiteman
ICRF General Practice Research Group, Institute of Health Sciences, Oxford, UK
Public Health Nutr 2:477-87. 1999..To determine whether responses to simple dietary questions are associated with specific causes of death... - Patients with cancer holding their own records: a randomised controlled trialM Drury
Department of Primary Health Care, University of Oxford
Br J Gen Pract 50:105-10. 2000..Patient-held records may facilitate effective, coordinated care, but no randomised controlled trials of their use in cancer care have been conducted, and concerns about possible negative effects remain... - Interleukin-4 induced down-regulation of skin homing receptor expression by human viral-specific CD8 T cells may contribute to atopic risk of cutaneous infectionS L Seneviratne
Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Clin Exp Immunol 141:107-15. 2005..Furthermore, the ability to modify the local and systemic microenvironment may offer novel therapeutic strategies that influence tissue-specific T cell homing... - A novel fluorescent sensitive assay for detection of differential T cell mediated lysis of multiple adherent target cellsAntony P Black
Cutaneous Immunology Group, MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK
J Immunol Methods 316:153-7. 2006..The assay allows simultaneous use of multiple differentially sensitised targets and facilitates concomitant surface or intracellular effector cell phenotypic analysis... - Dynamics of T cell responses in HIV infectionVictor Appay
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 168:3660-6. 2002..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision... - Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cellsAntony P B Black
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Eur J Immunol 37:1485-93. 2007..The findings have broad implications for the pathogenesis of cutaneous disease and for transcutaneous drug or vaccine delivery... - Rapid effector function of varicella-zoster virus glycoprotein I-specific CD4+ T cells many decades after primary infectionGathsaurie Neelika Malavige
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
J Infect Dis 195:660-4. 2007..We characterized the optimal peptide of the strongest response in our cohort showing restriction through DRB4*01. These findings are consistent with gI-specific CD4(+) T cell involvement in the control of VZV replication... - CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansionLing Pei Ho
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 7DS, UK
J Immunol 172:7350-8. 2004..We suggest that one mechanism by which CD1d-restricted NKT cells can exert a regulatory role is by containing the proliferation of activated T cells, possibly through timely lysis of APCs or activated T cells bearing CD1d... - Interleukin-4 promotes human CD8 T cell expression of CCR7Suranjith L Seneviratne
MRC Human Immunology Unit and University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
Immunology 120:66-72. 2007..IL-4 promotes expression of CCR7, a marker linked to existing models of CD8(+) T cell differentiation... - Persistent high frequencies of varicella-zoster virus ORF4 protein-specific CD4+ T cells after primary infectionLouise Jones
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
J Virol 80:9772-8. 2006..In summary, we have identified an ORF4 protein as a novel target antigen for persistent VZV-specific CD4+ T cells, with implications for disease pathogenesis and future vaccine development... - TLR2 is expressed on activated T cells as a costimulatory receptorMousa Komai-Koma
Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
Proc Natl Acad Sci U S A 101:3029-34. 2004..This suggests that pathogens, via their pathogen-associated molecular patterns, may contribute directly to the perpetuation and activation of long-term T cell memory in both antigen-dependent and independent manner... - Allergen-specific CD8(+) T cells and atopic diseaseSuranjith L Seneviratne
Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
J Clin Invest 110:1283-91. 2002..These data are consistent with a role for CD8(+) T cells in atopic disease pathogenesis and may provide a basis for future T cell immunotherapy strategies... - A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrenceA M Jones
Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
J Pathol 214:533-44. 2008..We believe it likely that unfavourable sub-clones not easily identified by histology account for the unpredictable clinical behaviour of these tumours... - Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapyGeorge J M Webster
Institute of Hepatology, University College London, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom
J Virol 78:5707-19. 2004..These findings have implications for the design of immunotherapy for chronic HBV infections... - Supportive care: experiences of cancer patientsLorraine Fincham
King s College London, 5th Floor, Waterloo Bridge Wing, Franklin Wilkins Building, 150 Stanford Street, London SE1 9NN, UK
Eur J Oncol Nurs 9:258-68. 2005....